Stem-loop mmu-mir-450a-1

Accession

MI0001653

Description

Mus musculus mmu-mir-450a-1 precursor miRNA

Gene family

MIPF0000128; mir-450

Literature search

7 open access papers mention mmu-mir-450a-1
(82 sentences)

Sequence

26557 reads, 231 reads per million, 100 experiments

gagagauacugagcuguUUUUGCGAUGUGUUCCUAAUAUgugcuauaauuauAUUGGGAACAUUUUGCAUAAAUagcuuugugucaauaca
....(((((.(((((((((.(((((.((((((((((((((.........)))))))))))))).))))).))))))))).)))))......

Structure

--gaga     u         U     U              ugc 
      gauac gagcuguUU UGCGA GUGUUCCUAAUAUg   u
      ||||| ||||||||| ||||| ||||||||||||||   a
      cugug uucgaUAAA ACGUU UACAAGGGUUAuau   u
acauaa     u         U     U              uaa 

Annotation confidence High

Comments

Xie et al. [1] refer to this sequence by the internal identifier MIR238. The sequence is unrelated to C. elegans mir-238 (MIR:MI0000313).

Genome context

chrX: 53048154-53048244 [-]

Clustered miRNAs

6 other miRNAs are < 10 kb from mmu-mir-450a-1

Mature mmu-miR-450a-5p

• Accession: MIMAT0001546
• Description: Mus musculus mmu-miR-450a-5p mature miRNA
• Sequence: 18 - UUUUGCGAUGUGUUCCUAAUAU - 39
• Evidence: experimental ; cloned [2], Illumina [3-4]

Mature mmu-miR-450a-1-3p

• Accession: MIMAT0017182
• Description: Mus musculus mmu-miR-450a-1-3p mature miRNA
• Sequence: 53 - AUUGGGAACAUUUUGCAUAAAU - 74
• Evidence: experimental ; Illumina [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


3. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


4. PubMed ID: 15735639
   Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals
   "Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M"
   "Nature (2005) 434:338-345