miRBase entry: hsa-mir-485

Stem-loop hsa-mir-485


Accession
MI0002469
Symbol
HGNC: MIR485
Description
Homo sapiens hsa-mir-485 precursor miRNA
Gene family
MIPF0000201; mir-485

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR485 is a microRNA that has been studied in various contexts, including pancreatic cancer, viral infections, and muscle cell regulation. In pancreatic cancer cells, a genetically engineered adenovirus called ICOVIR15 was developed to code for MIR485 and miR99b, which enhanced viral propagation and increased antitumoral activity [PMC9171400]. MIR485 has been shown to target RIG-I mRNA for degradation, impairing the antiviral response and promoting replication of the influenza A virus [PMC6370596]. In muscle cells, MIR485 was found to be downregulated in satellite cells lacking ERα (scERαKO), which resulted in the upregulation of genes promoting cell death and downregulation of genes promoting cell survival [PMC6655560]. In various studies using different animal models, including dogs and mice, MIR485 was found to be differentially expressed in response to different conditions or treatments [PMC8376273] [PMC10001410] [PMC6122344] [PMC4482373]. Additionally, MIR485 has been implicated in modulating the canonical Wnt pathway by negatively regulating FZD4, RAC-1, PKC (88), SFRP1 levels and positively regulating STB1 levels [PMC5285348]. Furthermore, elevated levels of MIR485 were found in various organs after treatment compared to untreated groups [PMC4605239]. Finally, micro-RNA miR-485-5p transcript is known to be deregulated in Alzheimer's disease patients [PMC5546543].

Literature search
64 open access papers mention hsa-mir-485
(200 sentences)

Sequence

7675 reads, 114 reads per million, 81 experiments
acuuggagAGAGGCUGGCCGUGAUGAAUUCgauucaucaaagcgaGUCAUACACGGCUCUCCUCUCUuuuagu
(((.(((((((((..(((((((((((.((((...........)))))))).)))))))..))))))))).)))

Structure
   u         CU       -    A    auuc 
acu ggagAGAGG  GGCCGUG AUGA UUCg    a
||| |||||||||  ||||||| |||| ||||    u
uga uuUCUCUCC  UCGGCAC UACU Gagc    c
   u         UC       A    -    gaaa 


Annotation confidence High
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Genome context
chr14: 101055419-101055491 [+]
Clustered miRNAs
16 other miRNAs are < 10 kb from hsa-mir-485
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-485 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-485-5p

Accession MIMAT0002175
Description Homo sapiens hsa-miR-485-5p mature miRNA
Sequence 9 - AGAGGCUGGCCGUGAUGAAUUC - 30
Evidence experimental
array-cloned [2], cloned [3]
Database links
Predicted targets

Mature hsa-miR-485-3p

Accession MIMAT0002176
Description Homo sapiens hsa-miR-485-3p mature miRNA
Sequence 46 - GUCAUACACGGCUCUCCUCUCU - 67
Evidence experimental
cloned [1,3], array-cloned [2]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15978578
    Identification of human fetal liver miRNAs by a novel method
    "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
    "FEBS Lett (2005) 579:3849-3854

  3. PubMed ID: 15965474
    Identification of hundreds of conserved and nonconserved human microRNAs
    "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
    "Nat Genet (2005) 37:766-770