miRBase entry: hsa-mir-146b

Stem-loop hsa-mir-146b


Accession
MI0003129
Symbol
HGNC: MIR146B
Description
Homo sapiens hsa-mir-146b precursor miRNA
Gene family
MIPF0000103; mir-146

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

Additionally, miRNA hsa-mir-146b is highly expressed in PB NK cells, and its target TRAF6 has been reported to down-regulate NF-kB activity, suppress cell proliferation, and enhance chemosensitivity [PMC3640206]. The expression, log2 fold change, and adjusted p-value of hsa-mir-146b, hsa-miR-375, hsa-miR-31, hsa-miR-7-2, and hsa-miR-204 were then extracted from the overall results [PMC4918724].

Literature search
387 open access papers mention hsa-mir-146b
(2112 sentences)

Sequence

434033 reads, 1123 reads per million, 129 experiments
ccuggcacUGAGAACUGAAUUCCAUAGGCUGugagcucuagcaauGCCCUGUGGACUCAGUUCUGGUgcccgg
((.((((((.((((((((..(((((((((..((........))..).)))))))).)))))))))))))).))

Structure
  u      G        AU        - UG  agc 
cc ggcacU AGAACUGA  UCCAUAGG C  ug   u
|| |||||| ||||||||  |||||||| |  ||    
gg ccgUGG UCUUGACU  AGGUGUCC G  ac   c
  c      -        -C        C ua  gau 


Annotation confidence High
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Genome context
chr10: 102436512-102436584 [+]

Disease association
hsa-mir-146b is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-146b-5p

Accession MIMAT0002809
Description Homo sapiens hsa-miR-146b-5p mature miRNA
Sequence 9 - UGAGAACUGAAUUCCAUAGGCUG - 31
Evidence experimental
array-cloned [1], cloned [2]
Database links
Predicted targets

Mature hsa-miR-146b-3p

Accession MIMAT0004766
Description Homo sapiens hsa-miR-146b-3p mature miRNA
Sequence 46 - GCCCUGUGGACUCAGUUCUGGU - 67
Evidence experimental
cloned [2]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15965474
    Identification of hundreds of conserved and nonconserved human microRNAs
    "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
    "Nat Genet (2005) 37:766-770