miRBase entry: hsa-mir-497

Stem-loop hsa-mir-497


Accession
MI0003138
Symbol
HGNC: MIR497
Description
Homo sapiens hsa-mir-497 precursor miRNA
Gene family
MIPF0000231; mir-497

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR497 is a microRNA that has been shown to regulate neuronal death following ischemia [PMC4998122]. However, a recent study has identified a new association between MIR497 and seizure-induced damage, making it the first to do so [PMC4998122]. Additionally, studies have demonstrated that MIR497 can sensitize lung cancer cells to cisplatin resistance treatment in an AKT2-dependent manner [PMC8787930]. Furthermore, it has been suggested that LINC00152 acts as a sponge and negatively regulates MIR497 [PMC7011539].

MicroRNAs are small non-coding RNA molecules that play crucial roles in gene regulation. MIR497 specifically has been found to be involved in neuronal death following ischemia [PMC4998122]. This indicates its potential importance in understanding and potentially treating ischemic brain injury. However, the present study is the first to establish an association between MIR497 and seizure-induced damage, expanding our understanding of its role in neurological disorders [PMC4998122].

In addition to its role in neuronal death and seizure-induced damage, MIR497 has also been implicated in lung cancer. It has been shown that MIR497 can sensitize lung cancer cells to cisplatin resistance treatment through an AKT2-dependent mechanism. This finding suggests the potential of targeting MIR497 as a therapeutic strategy for overcoming cisplatin resistance in lung cancer patients [PMC8787930].

Furthermore, LINC00152 has been identified as a negative regulator of MIR497. It acts as a sponge for this microRNA, potentially reducing its availability for gene regulation. This finding highlights the complexity of microRNA regulation and suggests LINC00152 as a potential therapeutic target for modulating the activity of MIR497 [PMC7011539].

Literature search
117 open access papers mention hsa-mir-497
(1034 sentences)

Sequence

37583 reads, 380 reads per million, 124 experiments
ccaccccgguccugcucccgcccCAGCAGCACACUGUGGUUUGUacggcacuguggccacgucCAAACCACACUGUGGUGUUAGAgcgagggugggggaggcaccgccgagg
...((.(((((((.((((((((((((((.((((.(((((((((.(((((......)))..)).))))))))).)))).)))).....).))))))))))))....)))).))

Structure
cca  c    ----   g         - -----    G    C         U  --   ac 
   cc cggu    ccu cucccgccc C     AGCA CACA UGUGGUUUG ac  ggc  u
   || ||||    ||| ||||||||| |     |||| |||| ||||||||| ||  |||   
   gg gccg    gga ggggguggg g     UUGU GUGU ACACCAAAC ug  ccg  g
---  a    ccac   -         a cgAGA    G    C         c  ca   gu 


Annotation confidence Not enough data
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Genome context
chr17: 7017911-7018022 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-497
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-497 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-497-5p

Accession MIMAT0002820
Description Homo sapiens hsa-miR-497-5p mature miRNA
Sequence 24 - CAGCAGCACACUGUGGUUUGU - 44
Evidence experimental
array-cloned [1], cloned [2]
Database links
Predicted targets

Mature hsa-miR-497-3p

Accession MIMAT0004768
Description Homo sapiens hsa-miR-497-3p mature miRNA
Sequence 64 - CAAACCACACUGUGGUGUUAGA - 85
Evidence experimental
cloned [2]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15965474
    Identification of hundreds of conserved and nonconserved human microRNAs
    "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
    "Nat Genet (2005) 37:766-770