Accession
MI0003140
Symbol
HGNC:
MIR512-1
Description
Homo sapiens
hsa-mir-512-1 precursor miRNA
Gene family
MIPF0000130;
mir-506
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR512-1 is a miRNA gene that belongs to the C19MC miRNA gene cluster. It is a placental-specific miRNA gene that has been found to have complex methylation patterns. The promoter of the pri-miRNA for MIR512-1 is maternally methylated in placenta but fully methylated in somatic tissues [PMC3975056]. The methylation profiling of the MIR512-1 cluster has revealed that the differentially methylated region (DMR) of MIR512-1 is unmethylated in hydatidiform moles compared to partially methylated placenta [PMC3975056]. The DMR of MIR512-1 is approximately 5 kb in size and includes the promoter CpG island [PMC3975056]. Interestingly, most placental-specific DMRs, including MIR512-1, do not inherit methylation from gametes and are devoid of methylation in human embryonic stem cells [PMC3975056'>PMC3975056]. These complex methylation states at the MIR512-1 locus dictate complex allelic expression, with restricted paternal expression of the MIR512-1 pri-miRNA and reciprocal imprinting of ZNF331 [PMC3975056]. Additionally, it has been found that there may be more unknown imprinted DMRs solely present in placental tissues, as highlighted by the presence of DMRs for both MIR512-1 and GPR1-AS [PMC3975056]. The cumulative expression levels of all 46 C19MC miRNA genes, including MIR512-1, have been analyzed in breast invasive carcinoma using miRNASeq dataset [PMC6193703].
Literature search
42 open access papers mention hsa-mir-512-1
(260 sentences)
(260 sentences)
Sequence
258
reads,
18
reads per million, 20 experiments
ucucagucuguggCACUCAGCCUUGAGGGCACUUUCuggugccagaaugaAAGUGCUGUCAUAGCUGAGGUCcaaugacugagg
.(((((((..(((..((((((..(((.(((((((((............))))))))).)))..))))))..)))..))))))).
.(((((((..(((..((((((..(((.(((((((((............))))))))).)))..))))))..)))..))))))).
Structure
u ug CA CU G uggug cucaguc ugg CUCAGC UGA GGCACUUUC c ||||||| ||| |||||| ||| ||||||||| gagucag acC GAGUCG ACU UCGUGAAag c g ua UG AU G uaaga
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr19: 53666679-53666762 [+]
Clustered miRNAs
4 other miRNAs are < 10 kb from hsa-mir-512-1
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-512-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-512-5p
| Accession | MIMAT0002822 |
| Description | Homo sapiens hsa-miR-512-5p mature miRNA |
| Sequence | 14 - CACUCAGCCUUGAGGGCACUUUC - 36 |
| Evidence |
experimental
array-cloned [1] |
Mature hsa-miR-512-3p
| Accession | MIMAT0002823 |
| Description | Homo sapiens hsa-miR-512-3p mature miRNA |
| Sequence | 51 - AAGUGCUGUCAUAGCUGAGGUC - 72 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
| Database links |
|
| Predicted targets |
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References
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