Accession
MI0003148
Symbol
HGNC:
MIR519C
Description
Homo sapiens
hsa-mir-519c precursor miRNA
Gene family
MIPF0000020;
mir-515
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR519C is a placenta-specific miRNA that is produced by trophoblasts and can be released as free miRNA or packaged into extracellular vesicles (EVs) [PMC6460512]. It has been shown to inhibit TNFα gene expression in placental explant models [PMC6460512]. MIR519C is part of the C19MC cluster on chromosome 19, which includes a total of 46 miRNA genes [PMC7378193]. It has been found to be disrupted in individuals from both the New World and Australia, along with other miRNAs such as MIR519B, MIR526B, and MIR519D [PMC3938728]. In breast invasive carcinoma, the expression of MIR519C and other miRNAs from the C19MC cluster has been analyzed and associated with stem cell biology and tumorigenesis [PMC8508841]. Additionally, several microRNAs including MIR519C have been shown to affect transcription stability and protein translation [PMC10138346]. The expression of all 46 C19MC miRNA genes, including MIR519C, has been analyzed in liver hepatocellular carcinoma (HCC) using TCGA datasets [PMC7378193]. Similarly, the cumulative expression of C19MC miRNA genes has also been analyzed in breast invasive carcinoma using RNA-seq datasets [PMC6193703]. References: - [PMC3938728]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938728/ - [PMC7378193]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378193/ - [PMC6460512]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460512/ - [PM10138346]: https://pubmed.ncbi.nlm.nih.gov/10138346/ - [PMC8508841]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508841/ - [PMC6193703]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193703/
Literature search
27 open access papers mention hsa-mir-519c
(69 sentences)
(69 sentences)
Sequence
106
reads,
15
reads per million, 22 experiments
ucucagccugugaccCUCUAGAGGGAAGCGCUUUCUGuugucugaaagaaaagAAAGUGCAUCUUUUUAGAGGAUuacaguuugaga
((((((.((((((.((((((((((((.(((((((((....(((...)))..))))))))).)))))))))))).)))))).))))))
((((((.((((((.((((((((((((.(((((((((....(((...)))..))))))))).)))))))))))).)))))).))))))
Structure
c c A Guug g
ucucag cuguga cCUCUAGAGGGA GCGCUUUCU ucu
|||||| |||||| |||||||||||| ||||||||| ||| a
agaguu gacauU GGAGAUUUUUCU CGUGAAAga aga
u A A --aa a
Annotation confidence
High
Do you think this miRNA is real?
Comments
The 5' arm of this precursor expresses a product related to miR-526 (previously named miR-526c here). Landgraf et al. confirm mature miRNA expression from both arms of the precursor [2], leading to the -5p, -3p designations. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chr19: 53686469-53686555 [+]
Clustered miRNAs
8 other miRNAs are < 10 kb from hsa-mir-519c
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-519c is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-519c-5p
| Accession | MIMAT0002831 |
| Description | Homo sapiens hsa-miR-519c-5p mature miRNA |
| Sequence | 16 - CUCUAGAGGGAAGCGCUUUCUG - 37 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-519c-3p
| Accession | MIMAT0002832 |
| Description | Homo sapiens hsa-miR-519c-3p mature miRNA |
| Sequence | 54 - AAAGUGCAUCUUUUUAGAGGAU - 75 |
| Evidence |
experimental
array-cloned [1] |
References
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