miRBase entry: hsa-mir-520c

Stem-loop hsa-mir-520c


Accession
MI0003158
Symbol
HGNC: MIR520C
Description
Homo sapiens hsa-mir-520c precursor miRNA
Gene family
MIPF0000020; mir-515

Literature search
62 open access papers mention hsa-mir-520c
(330 sentences)

Sequence

155 reads, 27 reads per million, 18 experiments
ucucaggcugucgucCUCUAGAGGGAAGCACUUUCUGuugucugaaagaaaagAAAGUGCUUCCUUUUAGAGGGUuaccguuugaga
((((((((.((..(((((((((((((((((((((((....(((...)))..)))))))))))))))))))))))..)).))))))))

Structure
        u  cg                       Guug   g 
ucucaggc gu  ucCUCUAGAGGGAAGCACUUUCU    ucu  
|||||||| ||  |||||||||||||||||||||||    ||| a
agaguuug ca  GGGAGAUUUUCCUUCGUGAAAga    aga  
        c  uU                       --aa   a 


Annotation confidence High
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Comments
The 5' arm of this precursor expresses a product related to miR-526 (previously named miR-526c here). Landgraf et al. confirm mature miRNA expression from both arms of the precursor [2], leading to the -5p, -3p designations. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr19: 53707453-53707539 [+]
Clustered miRNAs
11 other miRNAs are < 10 kb from hsa-mir-520c
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-520c is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-520c-5p

Accession MIMAT0005455
Description Homo sapiens hsa-miR-520c-5p mature miRNA
Sequence 16 - CUCUAGAGGGAAGCACUUUCUG - 37
Evidence experimental
array-cloned [1], cloned [2]

Mature hsa-miR-520c-3p

Accession MIMAT0002846
Description Homo sapiens hsa-miR-520c-3p mature miRNA
Sequence 54 - AAAGUGCUUCCUUUUAGAGGGU - 75
Evidence experimental
array-cloned [1], cloned [2]

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15965474
    Identification of hundreds of conserved and nonconserved human microRNAs
    "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
    "Nat Genet (2005) 37:766-770