Stem-loop hsa-mir-518c

Accession

MI0003159

Symbol

HGNC: MIR518C

Description

Homo sapiens hsa-mir-518c precursor miRNA

Gene family

MIPF0000020; mir-515

Literature search

16 open access papers mention hsa-mir-518c
(20 sentences)

Sequence

41 reads, 7 reads per million, 14 experiments

gcgagaagaucucaugcugugacUCUCUGGAGGGAAGCACUUUCUGuugucugaaagaaaaCAAAGCGCUUCUCUUUAGAGUGUuacgguuugagaaaagc
.........(((((.((((((((.((((((((((((((.(((..((((.(((...))).))))))).)))))))))))))).)))))))).))))).....

Structure

gcgagaaga     u        U              A   UC    g   g 
         ucuca gcugugac CUCUGGAGGGAAGC CUU  UGuu ucu  
         ||||| |||||||| |||||||||||||| |||  |||| ||| a
         agagu uggcauUG GAGAUUUCUCUUCG GAA  ACaa aga  
----cgaaa     u        U              C   --    a   a 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr19: 53708735-53708835 [+]

Clustered miRNAs

9 other miRNAs are < 10 kb from hsa-mir-518c

Disease association

hsa-mir-518c is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-518c-5p

• Accession: MIMAT0002847
• Description: Homo sapiens hsa-miR-518c-5p mature miRNA
• Sequence: 24 - UCUCUGGAGGGAAGCACUUUCUG - 46
• Evidence: experimental ; array-cloned [1]

Mature hsa-miR-518c-3p

• Accession: MIMAT0002848
• Description: Homo sapiens hsa-miR-518c-3p mature miRNA
• Sequence: 62 - CAAAGCGCUUCUCUUUAGAGUGU - 84
• Evidence: experimental ; array-cloned [1], cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770