Accession
MI0003160
Symbol
HGNC:
MIR524
Description
Homo sapiens
hsa-mir-524 precursor miRNA
Gene family
MIPF0000020;
mir-515
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR524 is a microRNA that is involved in various biological processes [PMC6193703]. It is part of the C19MC miRNA gene cluster, which consists of 46 miRNA genes [PMC6193703]. In breast invasive carcinoma, the expression of MIR524 is downregulated by an overexpressed EGFR/myc axis, leading to the activation of the TGF-β, Notch, and Hippo pathways [PMC9966483]. MIR524 also plays a role in regulating gene expression through its interaction with other molecules [PMC3938728]. It has been found to downregulate targets such as OLR1, CPEB4, and DUSP1 [PMC3938728]. Additionally, MIR524 is regulated by EGFR through recruitment of a repressive histone modifier to its promoter region [PMC7766154].
Literature search
16 open access papers mention hsa-mir-524
(254 sentences)
(254 sentences)
Sequence
59
reads,
10
reads per million, 15 experiments
ucucaugcugugaccCUACAAAGGGAAGCACUUUCUCuuguccaaaggaaaaGAAGGCGCUUCCCUUUGGAGUguuacgguuugaga
(((((.((((((((.((.(((((((((((.((((((....(((...)))..)))))).))))))))))).)).)))))))).)))))
(((((.((((((((.((.(((((((((((.((((((....(((...)))..)))))).))))))))))).)).)))))))).)))))
Structure
u c A A Cuug a
ucuca gcugugac CU CAAAGGGAAGC CUUUCU ucc
||||| |||||||| || ||||||||||| |||||| ||| a
agagu uggcauug GA GUUUCCCUUCG GGAAGa agg
u U G C --aa a
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr19: 53711002-53711088 [+]
Clustered miRNAs
9 other miRNAs are < 10 kb from hsa-mir-524
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-524 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-524-5p
| Accession | MIMAT0002849 |
| Description | Homo sapiens hsa-miR-524-5p mature miRNA |
| Sequence | 16 - CUACAAAGGGAAGCACUUUCUC - 37 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-524-3p
| Accession | MIMAT0002850 |
| Description | Homo sapiens hsa-miR-524-3p mature miRNA |
| Sequence | 53 - GAAGGCGCUUCCCUUUGGAGU - 73 |
| Evidence |
experimental
array-cloned [1] |
References
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