Accession
MI0003162
Symbol
HGNC:
MIR519D
Description
Homo sapiens
hsa-mir-519d precursor miRNA mir-515
Gene
family?
family?
RF00639;
mir-515
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR519D is a microRNA implicated in various cellular processes and diseases, including cancer [PMC8235499]. While it was not up-regulated in hypoxic hepatocellular carcinoma (HCC) cells [PMC5074303], it has been reported to be overexpressed in the majority of central nervous system (CNS) tumors, contradicting a previous report of its down-regulation and tumor-suppressive properties [PMC8235499]. In the context of non-alcoholic fatty liver disease (NAFLD), MIR519D is among the miRNAs that are elevated and directly target PPARĪ± mRNA [PMC9775974]. It has been validated to play a role in HCC tumorigenesis, along with other differentially expressed miRNAs (DEMs) [PMC6338110]. MIR519D is also associated with stem cell biology and tumorigenesis as part of the chromosome 19 microRNA cluster C19MC [PMC8508841]. Its expression was found to be increased in adipogenesis promoting stem cells but decreased in a subsequent stage of these cells, indicating its role in adipogenesis regulation [PMC6307768]. Furthermore, hypomethylation has been associated with increased expression of MIR519D in HCC, suggesting epigenetic regulation as a factor influencing its expression levels [PMC8904560].
Literature search
42 open access papers mention hsa-mir-519d
(164 sentences)
(164 sentences)
Sequence
54
reads,
6
reads per million, 12 experiments
ucccaugcugugacCCUCCAAAGGGAAGCGCUUUCUGUUuguuuucucuuaaaCAAAGUGCCUCCCUUUAGAGUGuuaccguuuggga
(((((.((.(((((.(((.(((((((.((((((..((((((........)))))))))))).))))))).))).))))).)).)))))
(((((.((.(((((.(((.(((((((.((((((..((((((........)))))))))))).))))))).))).))))).)).)))))
Structure
u u C C A UC uuu
uccca gc gugac CUC AAAGGGA GCGCUU UGUUug u
||||| || ||||| ||| ||||||| |||||| ||||||
agggu ug cauuG GAG UUUCCCU CGUGAA ACaaau c
u c U A C -- ucu
Annotation confidence
Not enough data
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chr19: 53713347-53713434 [+]
Clustered miRNAs
9 other miRNAs are < 10 kb from hsa-mir-519d
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-519d is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-519d-3p
| Accession | MIMAT0002853 |
| Description | Homo sapiens hsa-miR-519d-3p mature miRNA |
| Sequence | 54 - CAAAGUGCCUCCCUUUAGAGUG - 75 |
| Evidence |
experimental
array-cloned [1], cloned [2], Illumina [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-519d-5p
| Accession | MIMAT0026610 |
| Description | Homo sapiens hsa-miR-519d-5p mature miRNA |
| Sequence | 15 - CCUCCAAAGGGAAGCGCUUUCUGUU - 39 |
| Evidence |
experimental
Illumina [3] |
References
|
