Accession
MI0003169
Symbol
HGNC:
MIR518E
Description
Homo sapiens
hsa-mir-518e precursor miRNA
Gene family
MIPF0000020;
mir-515
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Hsa-mir-518e is a miRNA that has been found to be upregulated in pancreatic ductal adenocarcinoma (PDAC) tissues compared to adjacent normal controls [PMC5649611]. It is one of the 12 miRNAs that are upregulated in PDAC tissues, along with hsa-miR-10b, hsa-miR-575, hsa-miR-159a, hsa-miR-644, hsa-miR-581, hsa-miR-637, hsa-miR-935, hsa-miR-98, hsa-miR-513-3p, hsa-mir-518e (hsa) [PMC5649611]. Additionally, it has been found to be significantly dysregulated in 9 comparisons [PMC4268797]. In a study comparing neural stem cells (NSC) and induced pluripotent stem cells (iPSC), the expression of hsa-mir-518e was highly decreased in NSC cells compared to iPSC [PMC6696086]. This suggests that it may be a negative regulator of neural differentiation from iPSC [PMC6696086]. Furthermore, it has been identified as one of the miRNAs characteristic for the transition from iPSC to NSC along with other miRNAs such as mir-302 family and let7 family [PMC6696086]. In hepatocellular carcinoma (HCC), both hsa-mir518e and its homologue hsa-mir518b have been found to be upregulated [PMC5937522].
Literature search
9 open access papers mention hsa-mir-518e
(11 sentences)
(11 sentences)
Sequence
101
reads,
16
reads per million, 21 experiments
ucucaggcugugaccCUCUAGAGGGAAGCGCUUUCUGuuggcuaaaagaaaagAAAGCGCUUCCCUUCAGAGUGuuaacgcuuugaga
((((((((..((((.((((.((((((((((((((((...............)))))))))))))))).)))).))))..)).))))))
((((((((..((((.((((.((((((((((((((((...............)))))))))))))))).)))).))))..)).))))))
Structure
- ug c A Guuggc
ucucag gc ugac CUCU GAGGGAAGCGCUUUCU u
|||||| || |||| |||| |||||||||||||||| a
agaguu cg auuG GAGA UUCCCUUCGCGAAAga a
u ca U C aaagaa
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr19: 53729838-53729925 [+]
Clustered miRNAs
9 other miRNAs are < 10 kb from hsa-mir-518e
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-518e is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-518e-5p
| Accession | MIMAT0005450 |
| Description | Homo sapiens hsa-miR-518e-5p mature miRNA |
| Sequence | 16 - CUCUAGAGGGAAGCGCUUUCUG - 37 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-518e-3p
| Accession | MIMAT0002861 |
| Description | Homo sapiens hsa-miR-518e-3p mature miRNA |
| Sequence | 54 - AAAGCGCUUCCCUUCAGAGUG - 74 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
References
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