Accession
MI0003184
Symbol
HGNC:
MIR500A
Description
Homo sapiens
hsa-mir-500a precursor miRNA mir-500
Gene
family?
family?
RF01903;
mir-500
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR500A is a microRNA whose expression can be influenced by pharmacological interventions, as evidenced by a study where specific drugs were found to increase MIR500A promoter activity, suggesting a potential regulatory mechanism influenced by these compounds [PMC8253104]. The study further confirmed the specificity of the drugs' effect on MIR500A expression by demonstrating that treatment of parental SAOS 2 cells, which presumably do not have the same genetic alterations as the targeted cells, did not result in altered MIR500A expression [PMC8253104]. This finding is significant as it helps to rule out off-target effects of the drugs, reinforcing that the observed increase in promoter activity is likely due to a direct effect on MIR500A regulation [PMC8253104].
Literature search
33 open access papers mention hsa-mir-500a
(232 sentences)
(232 sentences)
Sequence
30079
reads,
96
reads per million, 151 experiments
gcucccccucucUAAUCCUUGCUACCUGGGUGAGAgugcugucugaaugcaAUGCACCUGGGCAAGGAUUCUGagagcgagagc
((((.(.(((((.(((((((((...(((((((....(((.........)))...))))))))))))))))..))))).).))))
((((.(.(((((.(((((((((...(((((((....(((.........)))...))))))))))))))))..))))).).))))
Structure
c c -U UAC AGAg ugu
gcuc c cucuc AAUCCUUGC CUGGGUG ugc c
|||| | ||||| ||||||||| ||||||| ||| u
cgag g gagaG UUAGGAACG GGUCCAC acg g
a c UC --- -GUA uaa
Annotation confidence
Medium
Do you think this miRNA is real?
Genome context
chrX: 50008431-50008514 [+]
Clustered miRNAs
7 other miRNAs are < 10 kb from hsa-mir-500a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-500a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-500a-5p
| Accession | MIMAT0004773 |
| Description | Homo sapiens hsa-miR-500a-5p mature miRNA |
| Sequence | 13 - UAAUCCUUGCUACCUGGGUGAGA - 35 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-500a-3p
| Accession | MIMAT0002871 |
| Description | Homo sapiens hsa-miR-500a-3p mature miRNA |
| Sequence | 52 - AUGCACCUGGGCAAGGAUUCUG - 73 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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