Stem-loop hsa-mir-500a

Accession

MI0003184

Symbol

HGNC: MIR500A

Description

Homo sapiens hsa-mir-500a precursor miRNA

Gene family

MIPF0000139; mir-500

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR500A is a microRNA that has been studied in the context of drug treatment in SAOS 2 cells. Treatment with certain drugs led to an increase in MIR500A promoter activity, as shown in Figure [PMC8253104]. However, the expression of MIR500A was not affected when parental SAOS 2 cells were treated with these drugs, ruling out any off-target effects [PMC8253104].

Literature search

33 open access papers mention hsa-mir-500a
(232 sentences)

Sequence

30079 reads, 268 reads per million, 151 experiments

gcucccccucucUAAUCCUUGCUACCUGGGUGAGAgugcugucugaaugcaAUGCACCUGGGCAAGGAUUCUGagagcgagagc
((((.(.(((((.(((((((((...(((((((....(((.........)))...))))))))))))))))..))))).).))))

Structure

    c c     -U         UAC       AGAg   ugu 
gcuc c cucuc  AAUCCUUGC   CUGGGUG    ugc   c
|||| | |||||  |||||||||   |||||||    |||   u
cgag g gagaG  UUAGGAACG   GGUCCAC    acg   g
    a c     UC         ---       -GUA   uaa 

Annotation confidence High

Genome context

chrX: 50008431-50008514 [+]

Clustered miRNAs

7 other miRNAs are < 10 kb from hsa-mir-500a

Disease association

hsa-mir-500a is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-500a-5p

• Accession: MIMAT0004773
• Description: Homo sapiens hsa-miR-500a-5p mature miRNA
• Sequence: 13 - UAAUCCUUGCUACCUGGGUGAGA - 35
• Evidence: experimental ; cloned [2]

Mature hsa-miR-500a-3p

• Accession: MIMAT0002871
• Description: Homo sapiens hsa-miR-500a-3p mature miRNA
• Sequence: 52 - AUGCACCUGGGCAAGGAUUCUG - 73
• Evidence: experimental ; array-cloned [1], cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770