Stem-loop hsa-mir-502

Accession

MI0003186

Symbol

HGNC: MIR502

Description

Homo sapiens hsa-mir-502 precursor miRNA mir-500

Gene
family

RF01903; mir-500

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR502 is a microRNA that has been studied for its role in cellular processes, particularly in the context of the cell cycle in PaTuT cells, as evidenced by flow cytometry analysis [PMC7002776]. The impact of MIR502 on cell cycle regulation suggests that it may play a significant role in cellular proliferation and differentiation within these specific tissues where it is prominently expressed [PMC7002776].

Literature search

21 open access papers mention hsa-mir-502
(40 sentences)

Sequence

22242 reads, 92 reads per million, 124 experiments

ugcucccccucucuaAUCCUUGCUAUCUGGGUGCUAgugcuggcucaaugcAAUGCACCUGGGCAAGGAUUCAgagagggggagcu
.((((((((((((((((((((((...((((((((...(((.........)))..))))))))))))))))).))))))))))))).

Structure

u             -         UAU        UAg   ugg 
 gcucccccucucu aAUCCUUGC   CUGGGUGC   ugc   c
 ||||||||||||| |||||||||   ||||||||   |||   u
 cgagggggagagA UUAGGAACG   GGUCCACG   Acg   c
u             C         ---        -UA   uaa 

Annotation confidence Medium

Comments

Extensive cloning studies suggest that the 3' product may be the predominant one [2].

Genome context

chrX: 50014598-50014683 [+]

Clustered miRNAs

5 other miRNAs are < 10 kb from hsa-mir-502

Disease association

hsa-mir-502 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-502-5p

• Accession: MIMAT0002873
• Description: Homo sapiens hsa-miR-502-5p mature miRNA
• Sequence: 16 - AUCCUUGCUAUCUGGGUGCUA - 36
• Evidence: experimental ; array-cloned [1]

Mature hsa-miR-502-3p

• Accession: MIMAT0004775
• Description: Homo sapiens hsa-miR-502-3p mature miRNA
• Sequence: 52 - AAUGCACCUGGGCAAGGAUUCA - 73
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770