miRBase entry: hsa-mir-376a-2

Stem-loop hsa-mir-376a-2


Accession
MI0003529
Symbol
HGNC: MIR376A2
Description
Homo sapiens hsa-mir-376a-2 precursor miRNA
Gene family
MIPF0000091; mir-368

Literature search
79 open access papers mention hsa-mir-376a-2
(405 sentences)

Sequence

1762 reads, 68 reads per million, 67 experiments
gguauuuaaaaGGUAGAUUUUCCUUCUAUGGUuacguguuugaugguuaAUCAUAGAGGAAAAUCCACGUuuucaguauc
((((((.((((.((.(((((((((.((((((((((((.....)))..)))))))))))))))))).)).)))).))))))

Structure
      u    G  A         U         --   g 
gguauu aaaa GU GAUUUUCCU CUAUGGUua  cgu u
|||||| |||| || ||||||||| |||||||||  ||| u
cuauga uuuU CA CUAAAAGGA GAUACUAau  gua u
      c    G  C         -         ug   g 


Annotation confidence High
Do you think this miRNA is real?
Comments
The mature miR-376a products have been shown to be modified by A to I edits [2].

Genome context
chr14: 101040069-101040148 [+]
Clustered miRNAs
15 other miRNAs are < 10 kb from hsa-mir-376a-2
Name Accession Chromosome Start End Strand Confidence




Database links

Mature hsa-miR-376a-3p

Accession MIMAT0000729
Description Homo sapiens hsa-miR-376a-3p mature miRNA
Sequence 50 - AUCAUAGAGGAAAAUCCACGU - 70
Evidence experimental
cloned [1,3], SOLiD [4]
Database links
Predicted targets

Mature hsa-miR-376a-2-5p

Accession MIMAT0022928
Description Homo sapiens hsa-miR-376a-2-5p mature miRNA
Sequence 12 - GGUAGAUUUUCCUUCUAUGGU - 32
Evidence experimental
SOLiD [4]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15891114
    Clustering and conservation patterns of human microRNAs
    "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
    "Nucleic Acids Res (2005) 33:2697-2706

  3. PubMed ID: 17322061
    Redirection of silencing targets by adenosine-to-inosine editing of miRNAs
    "Kawahara Y, Zinshteyn B, Sethupathy P, Iizasa H, Hatzigeorgiou AG, Nishikura K"
    "Science (2007) 315:1137-1140

  4. PubMed ID: 22282338
    Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs
    "Voellenkle C, Rooij Jv, Guffanti A, Brini E, Fasanaro P, Isaia E, Croft L, David M, Capogrossi MC, Moles A, Felsani A, Martelli F"
    "RNA (2012) 18:472-484