Accession
MI0003602
Symbol
HGNC:
MIR590
Description
Homo sapiens
hsa-mir-590 precursor miRNA
Gene family
MIPF0000418;
mir-590
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR590 is a microRNA that has been found to be upregulated in various conditions, including in all pulmonary arterial hypertension (PA) cases [PMC7652879]. The MIR590 gene contains a single estrogen receptor alpha (ERα) binding site in its promoter region, located 1050 base pairs upstream of the transcription start site [PMC6328622]. Antisense oligonucleotides against MIR590 have been shown to reverse its effects [PMC7215603]. MIR590 has also been found to target Tob1 and TGFβR2, suggesting its role in cardiac fibrosis and epithelial-mesenchymal transition (EMT) [PMC9564062] [PMC4626157]. Additionally, MIR590 has been associated with myocarditis and heart failure [PMC9589260]. It has also been shown to regulate Sp1 expression levels and be involved in various downstream sub-networks, including glucose metabolism and microRNA regulation [PMC5210349] [PMC6052129]. In cancer, MIR590 acts as an oncogene by targeting PPM1F and is a prognostic factor for tumor recurrence [PMC8743668]. It is also involved in EMT along with miR182 and miR183 [PMC7575175] [PMC8743668].
Literature search
68 open access papers mention hsa-mir-590
(418 sentences)
(418 sentences)
Sequence
92304
reads,
996
reads per million, 152 experiments
uagccagucagaaauGAGCUUAUUCAUAAAAGUGCAGuauggugaagucaaucugUAAUUUUAUGUAUAAGCUAGUcucugauugaaacaugcagca
....((((((((.((.(((((((.(((((((.(((((..(((.....)))..))))).))))))).))))))).)).))))))))............
....((((((((.((.(((((((.(((((((.(((((..(((.....)))..))))).))))))).))))))).)).))))))))............
Structure
--------uagc a G U G ua u
cagucaga au AGCUUAU CAUAAAA UGCAG ugg g
|||||||| || ||||||| ||||||| ||||| ||| a
guuagucu UG UCGAAUA GUAUUUU AUguc acu a
acgacguacaaa c A U A ua g
Annotation confidence
High
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Genome context
chr7: 74191198-74191294 [+]
Disease association
hsa-mir-590 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-590-5p
| Accession | MIMAT0003258 |
| Description | Homo sapiens hsa-miR-590-5p mature miRNA |
| Sequence | 16 - GAGCUUAUUCAUAAAAGUGCAG - 37 |
| Evidence |
experimental
Microarray [1], SAGE [1], cloned [2] |
| Database links |
|
| Predicted targets |
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Mature hsa-miR-590-3p
| Accession | MIMAT0004801 |
| Description | Homo sapiens hsa-miR-590-3p mature miRNA |
| Sequence | 56 - UAAUUUUAUGUAUAAGCUAGU - 76 |
| Evidence |
experimental
cloned [2] |
| Database links |
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| Predicted targets |
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References
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