miRBase entry: hsa-mir-625

Stem-loop hsa-mir-625


Accession
MI0003639
Symbol
HGNC: MIR625
Description
Homo sapiens hsa-mir-625 precursor miRNA
Gene family
MIPF0000534; mir-625

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

Hsa-mir-625 is a microRNA that has been found to be down-regulated in various conditions, including Alzheimer's disease (AD) [PMC3205057]. It is one of the microRNAs predicted to target multiple genes associated with AD [PMC9312389]. Hsa-mir-625 has also been identified as one of the miRNAs that can be used to distinguish different types of lymphomas [PMC4335255]. Additionally, it has been found to be differentially expressed in various cancers, including breast cancer [PMC6412941] and pancreatic cancer [PMC7942015]. The upregulation of hsa-mir-625 has been investigated for its effect on apoptosis and proliferation in a specific cell line [PMC9375600]. In human oocytes, hsa-mir-625 was found to be up-regulated in mature oocytes compared to immature ones [PMC4919285]. The variant deletion allele of hsa-mir-625 has been associated with changes in its minimum free energy (MFE) and potential target sites for other miRNAs have been identified within its sequence [PMC3444488] [PMC4008537]. Hsa-mir-625 is also mentioned as one of the miRNA precursors with previously unreported antisense transcripts [PMC3722126]. Finally, it has been identified as one of the RNA molecules transferred from pancreatic cancer cells to osteoblasts via small extracellular vesicles (sEVs) for intercellular communication [PMC8056276].

Literature search
40 open access papers mention hsa-mir-625
(457 sentences)

Sequence

26318 reads, 196 reads per million, 124 experiments
aggguagagggaugAGGGGGAAAGUUCUAUAGUCCuguaauuagaucucagGACUAUAGAACUUUCCCCCUCAucccucugcccu
(((((((((((((((((((((((((((((((((((((...........)))))))))))))))))))))))))))))))))))))

Structure
                                     uaau 
aggguagagggaugAGGGGGAAAGUUCUAUAGUCCug    u
|||||||||||||||||||||||||||||||||||||    a
ucccgucucccuACUCCCCCUUUCAAGAUAUCAGgac    g
                                     ucua 


Annotation confidence High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr14: 65471102-65471186 [+]

Disease association
hsa-mir-625 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-625-5p

Accession MIMAT0003294
Description Homo sapiens hsa-miR-625-5p mature miRNA
Sequence 15 - AGGGGGAAAGUUCUAUAGUCC - 35
Evidence experimental
Microarray [1], RT-PCR [1], SAGE [1], cloned [2]
Database links
Predicted targets

Mature hsa-miR-625-3p

Accession MIMAT0004808
Description Homo sapiens hsa-miR-625-3p mature miRNA
Sequence 52 - GACUAUAGAACUUUCCCCCUCA - 73
Evidence experimental
cloned [2]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 16505370
    The colorectal microRNAome
    "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
    "Proc Natl Acad Sci U S A (2006) 103:3687-3692