Accession
MI0003666
Symbol
HGNC:
MIR651
Description
Homo sapiens
hsa-mir-651 precursor miRNA
Gene family
MIPF0000478;
mir-651
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR651 is a microRNA that is deleted in certain genetic conditions, such as DGDP289B, and is also positively correlated with the development of hepatocellular carcinoma (HCC) [PMC3929543] [PMC7019335] [PMC9495750]. The variant allele (C) of rs149259359 may disrupt binding sites for several miRNAs, including MIR651 [PMC6969370]. In a patient with a genetic disorder, a copy number gain at Xp22.31 encompassed the MIR651 gene [PMC4498854]. MIR651 is one of several miRNAs that positively correlated with serum IP10 and MCP-1 levels and were more commonly observed in individuals who developed HCC [PMC9495750]. In addition to HCC development, MIR651 has been found to have intimate interactions with other miRNAs such as MIR193A, MIR140, MIR214, MIR34A, and MIR130A [PMC6714963]. Overall, the research suggests that MIR651 plays a role in genetic conditions and HCC development.
Literature search
3 open access papers mention hsa-mir-651
(3 sentences)
(3 sentences)
Sequence
1816
reads,
90
reads per million, 114 experiments
aaucuaucacugcuuUUUAGGAUAAGCUUGACUUUUGuucaaauaaaaaugcaAAAGGAAAGUGUAUCCUAAAAGgcaaugacaguuuaauguguuu
...((.(((.((((((((((((((.((((..(((((((............)))))))..)))).)))))))))))))).))).))............
...((.(((.((((((((((((((.((((..(((((((............)))))))..)))).)))))))))))))).))).))............
Structure
---------aau a c A GA ucaaa
cu uca ugcuuUUUAGGAUA GCUU CUUUUGu u
|| ||| |||||||||||||| |||| |||||||
ga agu acgGAAAAUCCUAU UGAA GAAAacg a
uuuguguaauuu c a G AG uaaaa
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chrX: 8126965-8127061 [+]
Disease association
hsa-mir-651 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-651-5p
| Accession | MIMAT0003321 |
| Description | Homo sapiens hsa-miR-651-5p mature miRNA |
| Sequence | 16 - UUUAGGAUAAGCUUGACUUUUG - 37 |
| Evidence |
experimental
RT-PCR [1], SAGE [1], cloned [2], Illumina [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-651-3p
| Accession | MIMAT0026624 |
| Description | Homo sapiens hsa-miR-651-3p mature miRNA |
| Sequence | 54 - AAAGGAAAGUGUAUCCUAAAAG - 75 |
| Evidence |
experimental
Illumina [3] |
| Database links |
|
| Predicted targets |
|
References
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