Accession
MI0003676
Symbol
HGNC:
MIR654
Description
Homo sapiens
hsa-mir-654 precursor miRNA mir-654
Gene
family?
family?
RF01922;
mir-654
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR654 is a microRNA gene that gives rise to miRNAs involved in various biological processes, including carcinogenesis, with miR-654-3p and miR-654-5p being its mature products [PMC9224266]. The lncRNA EMX2OS has been shown to interact with MIR654, suppressing its expression and consequently leading to increased PD-L1 levels and enhanced proliferation, invasion, and spheroid formation in ovarian cancer cells [PMC8974003]. MIR654 was examined but not found to be among the aberrantly expressed miRNAs in head and neck cancers [PMC5354851]. Additionally, MIR654 has been implicated in the immune response to viral infections; studies have demonstrated that MIR654 can inhibit the replication of influenza viruses by targeting specific viral components [PMC3774802], [PMC5360757].
Literature search
29 open access papers mention hsa-mir-654
(78 sentences)
(78 sentences)
Sequence
4783
reads,
22
reads per million, 84 experiments
ggguaaguggaaagaUGGUGGGCCGCAGAACAUGUGCugaguucgugccaUAUGUCUGCUGACCAUCACCUUuagaagccc
((((......((((.((((((.(.(((((.(((((((.........).))))))))))).).)))))).))))....))))
((((......((((.((((((.(.(((((.(((((((.........).))))))))))).).)))))).))))....))))
Structure
aagugg a G C A - uga
gggu aaag UGGUGG C GCAGA CAUGUG C g
|||| |||| |||||| | ||||| |||||| | u
cccg uUUC ACUACC G CGUCU GUAUac g u
--aaga C A U - c ugc
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr14: 101040219-101040299 [+]
Clustered miRNAs
15 other miRNAs are < 10 kb from hsa-mir-654
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-654 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-654-5p
| Accession | MIMAT0003330 |
| Description | Homo sapiens hsa-miR-654-5p mature miRNA |
| Sequence | 16 - UGGUGGGCCGCAGAACAUGUGC - 37 |
| Evidence |
experimental
Microarray [1], SAGE [1], cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-654-3p
| Accession | MIMAT0004814 |
| Description | Homo sapiens hsa-miR-654-3p mature miRNA |
| Sequence | 51 - UAUGUCUGCUGACCAUCACCUU - 72 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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