miRBase entry: gga-mir-499

Stem-loop gga-mir-499


Accession
MI0003710
Description
Gallus gallus gga-mir-499 precursor miRNA
Gene family
MIPF0000173; mir-499

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

Gga-mir-499 is a differentially expressed miRNA related to muscle function [PMC7326969]. It is one of the targets used to construct miRNA-lncRNA and miRNA-circRNA interaction network diagrams [PMC8531282]. The role of gga-mir-499, along with other miRNAs such as gga-miR-1, gga-miR-196-5p, gga-miR-193a-3p, gga-miR-34a-5p, gga-miR-221-5p, and gga-miR-126-3p, has been extensively studied in myofiber type [PMC8531282]. The correlation coefficients of these miRNAs with other factors ranged from 0.63 to 0.99 [PMC7038564]. Gga-mir-499 has been predicted to target ACVR2B in a network analysis [PMC9364561]. In the ovary, gga-mir-499 is associated with multiple pathways including reproductive processes, cell cycle, p53 pathway, and apoptosis [PMC5940789]. Gga-mir 499 is one of the muscle-related miRNAs differentially expressed between broilers and layers [PMC3107184]. It has been predicted to target ACVR2B along with two other miRNAs: gga-miR101 and gaa-miR1a [PMC3107184].

References:
[PMC7326969] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326969/
[PMC8531282] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531282/
[PMC7038564] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038564/
[PM9364561] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364561/
[PMC5940789] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940789/
[PMC3107184] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107184/

Literature search
10 open access papers mention gga-mir-499
(32 sentences)

Sequence

1116889 reads, 12379 reads per million, 5 experiments
uuugagggagcggcagUUAAGACUUGUAGUGAUGUUUAGauaauguauuacaugAACAUCACUUUAAGUCUGUGCUacuucucuccucauu
..((((((((.((.(((..(((((((.(((((((((((..(((....)))..))))))))))).)))))))..))).)).))).)))))..

Structure
uu     -   c  c   UA       U           Ga   u 
  ugagg gag gg agU  AGACUUG AGUGAUGUUUA  uaa g
  ||||| ||| || |||  ||||||| |||||||||||  |||  
  acucc cuc uc UCG  UCUGAAU UCACUACAAgu  auu u
uu     u   u  a   UG       U           ac   a 


Annotation confidence High
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Genome context
chr20: 2734854-2734944 [-]

Database links

Mature gga-miR-499-5p

Accession MIMAT0003367
Description Gallus gallus gga-miR-499-5p mature miRNA
Sequence 17 - UUAAGACUUGUAGUGAUGUUUAG - 39
Evidence experimental
Illumina [1]
Database links
Predicted targets

Mature gga-miR-499-3p

Accession MIMAT0026634
Description Gallus gallus gga-miR-499-3p mature miRNA
Sequence 55 - AACAUCACUUUAAGUCUGUGCU - 76
Evidence experimental
Illumina [1]
Database links
Predicted targets

References

  1. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45