miRBase entry: ebv-mir-BART3

Stem-loop ebv-mir-BART3


Accession
MI0003725
Description
Epstein Barr virus ebv-mir-BART3 precursor miRNA
Gene family
MIPF0000324; mir-BART3


Sequence

ccuuugguggaACCUAGUGUUAGUGUUGUGCUguaaauaaguguccagCGCACCACUAGUCACCAGGUGUcaccggagg
((((((((((.((((.(((((((((.(((((((............))))))).)))))).))).)))).))))))))))

Structure
          a    A   -      U       uaaau 
ccuuuggugg ACCU GUG UUAGUG UGUGCUg     a
|||||||||| |||| ||| |||||| |||||||      
ggaggccacU UGGA CAC GAUCAC ACGCgac     a
          G    C   U      C       cugug 


Annotation confidence Not enough data
Do you think this miRNA is real?
Comments
mir-BART3 was discovered independently by two groups. Cai et al identified mature miRNA products from both arms of the hairpin precursor and mapped the ends of the mature sequences by cloning [1]. Grundhoff et al confirmed that the 5' arm gives rise to a mature miRNA product, but didnot experimentally determine the extents of that product [2]. The mature miRNA names reflect cloning frequencies from Landgraf et al. [3], and may differ subtly from previous annotations. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3]. The ends of the miRNA may be offset with respect to previous annotations.

Genome context
HHV507799: 139076-139154 [+]
Clustered miRNAs
20 other miRNAs are < 10 kb from ebv-mir-BART3
Name Accession Chromosome Start End Strand Confidence




Disease association
ebv-mir-BART3 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature ebv-miR-BART3-5p

Accession MIMAT0003410
Description Epstein Barr virus ebv-miR-BART3-5p mature miRNA
Sequence 12 - ACCUAGUGUUAGUGUUGUGCU - 32
Evidence experimental
cloned [1,3], array [2], Northern [2]

Mature ebv-miR-BART3-3p

Accession MIMAT0003411
Description Epstein Barr virus ebv-miR-BART3-3p mature miRNA
Sequence 49 - CGCACCACUAGUCACCAGGUGU - 70
Evidence experimental
cloned [1,3]

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 16557291
    Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed
    Cai X, Schäfer A, Lu S, Bilello JP, Desrosiers RC, Edwards R, Raab-Traub N, Cullen BR
    PLoS Pathog (2006) 2:e23

  3. PubMed ID: 16540699
    A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses
    "Grundhoff A, Sullivan CS, Ganem D"
    "RNA (2006) 12:733-750