miRBase entry: kshv-mir-K12-12

Stem-loop kshv-mir-K12-12

Accession

MI0004987

Description

Kaposi sarcoma-associated herpesvirus kshv-mir-K12-12 precursor miRNA

Sequence

gauggccggcacgcggugucAACCAGGCCACCAUUCCUCUCCGcauuaaagcacucggUGGGGGAGGGUGCCCUGGUUGAcacaaugugccgcgcauc
((((..(((((((..((((((((((((.((((.((((((.(((............))).)))))).)))).))))))))))))..)))))))..))))

Structure

    gc       cg            C    A      U   cauua 
gaug  cggcacg  gugucAACCAGG CACC UUCCUC CCG     a
||||  |||||||  |||||||||||| |||| |||||| |||      
cuac  gccgugu  cacAGUUGGUCC GUGG AGGGGG ggc     a
    gc       aa            C    G      U   ucacg

Annotation confidence Not enough data

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Genome context

KSU75698: 117674-117771 [-]

Clustered miRNAs

11 other miRNAs are < 10 kb from kshv-mir-K12-12

Name	Accession	Chromosome	Start	End	Strand	Confidence

Disease association

kshv-mir-K12-12 is associated with one or more human diseases in the Human microRNA Disease Database

Disease	Description	Category	PubMed ID

Database links

Mature kshv-miR-K12-12-5p

Accession	MIMAT0003712
Description	Kaposi sarcoma-associated herpesvirus kshv-miR-K12-12-5p mature miRNA
Sequence	21 - AACCAGGCCACCAUUCCUCUCCG - 43
Evidence	experimental array [1], Northern [1], Illumina [2], SOLiD [3]

Mature kshv-miR-K12-12-3p

Accession	MIMAT0015238
Description	Kaposi sarcoma-associated herpesvirus kshv-miR-K12-12-3p mature miRNA
Sequence	59 - UGGGGGAGGGUGCCCUGGUUGA - 80
Evidence	experimental Illumina [2], SOLiD [3]

References

PubMed ID: 19889781
In-depth analysis of Kaposi's sarcoma-associated herpesvirus microRNA expression provides insights into the mammalian microRNA-processing machinery
"Umbach JL, Cullen BR"
"J Virol (2010) 84:695-703

PubMed ID: 20566670
Small RNA profiling reveals antisense transcription throughout the KSHV genome and novel small RNAs
"Lin YT, Kincaid RP, Arasappan D, Dowd SE, Hunicke-Smith SP, Sullivan CS"
"RNA (2010) 16:1540-1558

PubMed ID: 16540699
A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses
"Grundhoff A, Sullivan CS, Ganem D"
"RNA (2006) 12:733-750