miRBase entry: hsa-mir-877

Stem-loop hsa-mir-877


Accession
MI0005561
Symbol
HGNC: MIR877
Description
Homo sapiens hsa-mir-877 precursor miRNA
Gene family
MIPF0000392; mir-877

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

hsa-mir-877 is a microRNA that has been reported as an oncogene in gastric cancer [PMC7794682]. In nonresponder samples of both lung squamous cell carcinoma (LUSC) and head and neck squamous cell carcinoma (HNSC), hsa-mir-877 was found to be upregulated, along with hsa-miR-130a and hsa-miR-15a [PMC7794682]. Furthermore, in a study on endometrial cancer (EC), hsa-mir-877 was identified as one of the candidate reference genes that showed uniform expression [PMC3531299].

Literature search
31 open access papers mention hsa-mir-877
(62 sentences)

Sequence

10072 reads, 170 reads per million, 97 experiments
GUAGAGGAGAUGGCGCAGGGgacacgggcaaagacuuggggguuccugggacccucagacgugugUCCUCUUCUCCCUCCUCCCAG
...((((((..((.(.((((((((((.(.......((((((((((...)))))))))).).)))))))))).).))))))))....

Structure
-GUA      AU  C C          g caaagac          c 
    GAGGAG  GG G AGGGgacacg g       uuggggguuc  
    ||||||  || | |||||||||| |       |||||||||| u
    CUCCUC  CC C UCUCCUgugu c       gacucccagg  
GACC      --  U U          g ------a          g 


Annotation confidence High
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Comments
This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression was later confirmed by cloning [2].

Genome context
chr6: 30584332-30584417 [+]

Disease association
hsa-mir-877 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-877-5p

Accession MIMAT0004949
Description Homo sapiens hsa-miR-877-5p mature miRNA
Sequence 1 - GUAGAGGAGAUGGCGCAGGG - 20
Evidence experimental
cloned [1-3]
Database links
Predicted targets

Mature hsa-miR-877-3p

Accession MIMAT0004950
Description Homo sapiens hsa-miR-877-3p mature miRNA
Sequence 66 - UCCUCUUCUCCCUCCUCCCAG - 86
Evidence experimental
cloned [1-3]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 16954537
    Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
    "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
    "Genome Res (2006) 16:1289-1298

  3. PubMed ID: 17964270
    Mammalian mirtron genes
    "Berezikov E, Chung WJ, Willis J, Cuppen E, Lai EC"
    "Mol Cell (2007) 28:328-336