Stem-loop hsa-mir-216b

Accession

MI0005569

Symbol

HGNC: MIR216B

Description

Homo sapiens hsa-mir-216b precursor miRNA mir-216

Gene
family

RF00654; mir-216

Literature search

57 open access papers mention hsa-mir-216b
(186 sentences)

Sequence

476 reads, 39 reads per million, 34 experiments

gcagacuggaAAAUCUCUGCAGGCAAAUGUGAugucacugaggaaaucACACACUUACCCGUAGAGAUUCUAcagucugaca
.(((((((...(((((((((.((.((.((((((.((......)).))))))...)).)).)))))))))...)))))))...

Structure

--g       gaA         A  C  --A      g  ac 
   cagacug   AAUCUCUGC GG AA   UGUGAu uc  u
   |||||||   ||||||||| || ||   |||||| ||   
   gucugac   UUAGAGAUG CC UU   ACAcua ag  g
aca       AUC         C  A  CAC      a  ga 

Annotation confidence Not enough data

Comments

This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression was later confirmed by cloning [2].

Genome context

chr2: 56000714-56000795 [-]

Disease association

hsa-mir-216b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-216b-5p

• Accession: MIMAT0004959
• Description: Homo sapiens hsa-miR-216b-5p mature miRNA
• Sequence: 11 - AAAUCUCUGCAGGCAAAUGUGA - 32
• Evidence: experimental ; cloned [2], Illumina [3]

Mature hsa-miR-216b-3p

• Accession: MIMAT0026721
• Description: Homo sapiens hsa-miR-216b-3p mature miRNA
• Sequence: 49 - ACACACUUACCCGUAGAGAUUCUA - 72
• Evidence: experimental ; Illumina [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298


3. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45