Stem-loop hsa-mir-208b

Accession

MI0005570

Symbol

HGNC: MIR208B

Description

Homo sapiens hsa-mir-208b precursor miRNA mir-208

Gene
family

RF00749; mir-208

Literature search

101 open access papers mention hsa-mir-208b
(409 sentences)

Sequence

2570 reads, 47 reads per million, 14 experiments

ccucucagggAAGCUUUUUGCUCGAAUUAUGUuucugauccgaauAUAAGACGAACAAAAGGUUUGUcugagggcag
.((((((((.((((((((((.(((..((((((((.......))))))))..))).)))))))))).))))))))...

Structure

--c        g          C   AA        cu 
   cucucagg AAGCUUUUUG UCG  UUAUGUuu  g
   |||||||| |||||||||| |||  ||||||||  a
   gggagucU UUUGGAAAAC AGC  AAUAuaag  u
gac        G          A   AG        cc 

Annotation confidence High

Comments

This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression was later confirmed by cloning [2].

Genome context

chr14: 23417987-23418063 [-]

Disease association

hsa-mir-208b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-208b-3p

• Accession: MIMAT0004960
• Description: Homo sapiens hsa-miR-208b-3p mature miRNA
• Sequence: 46 - AUAAGACGAACAAAAGGUUUGU - 67
• Evidence: experimental ; cloned [2], Illumina [3]

Mature hsa-miR-208b-5p

• Accession: MIMAT0026722
• Description: Homo sapiens hsa-miR-208b-5p mature miRNA
• Sequence: 11 - AAGCUUUUUGCUCGAAUUAUGU - 32
• Evidence: experimental ; Illumina [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298


3. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45