Stem-loop hsa-mir-3609

Accession

MI0015999

Symbol

HGNC: MIR3609

Description

Homo sapiens hsa-mir-3609 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR3609 is a downregulated miRNA that has been identified as a potential biomarker for patients with locally advanced breast cancer [PMC9818474]. In kalirin–GEF1–inhibited cells, the miRNA precursors MIR181A2 and MIR3609 were found to be downregulated, which may explain the upregulation of miR-181 and miR-3609 targets [PMC8017594]. MIR3609 has been shown to improve the immune response in breast cancer by blocking the programmed death-ligand 1 immune checkpoint [PMC7527443]. Specifically, MIR3609 can bind to the 3′ UTR region of PD-L1 and suppress PD-L1 expression, thereby sensitizing breast cancer cells to doxorubicin [PMC9713762]. Functional analysis of downregulated miRNAs, including miR-24-2-5p, MIR3609, and miR-664b-3p, revealed that their target genes are involved in positive regulation processes such as cell morphogenesis, nervous system development, and neuron differentiation [PMC9727336]. Additionally, upregulation of MIR3609 has been shown to sensitize breast cancer cells to Adriamycin [PMC9727336]. Overall, these findings highlight the potential role of MIR3609 in breast cancer progression and treatment response.

Literature search

1 open access papers mention hsa-mir-3609
(3 sentences)

Sequence

1446 reads, 416 reads per million, 78 experiments

guaacaguaacuuuuauucucauuuuccuuuucucuaccuuguagagaagCAAAGUGAUGAGUAAUACUGGCUGgagccc
((..((((.....(((((((((((((...(((((((((...))))))))).))))))).)))))).....))))..))..

Structure

--  aa    aacuu      -       ccu         c 
  gu  cagu     uuauuc ucauuuu   uuucucuac  
  ||  ||||     |||||| |||||||   ||||||||| u
  cg  GUCG     AAUGAG AGUGAAA   gaagagaug  
cc  ag    GUCAU      U       --C         u 

Annotation confidence Not enough data

Genome context

chr7: 98881650-98881729 [+]

Mature hsa-miR-3609

• Accession: MIMAT0017986
• Description: Homo sapiens hsa-miR-3609 mature miRNA
• Sequence: 51 - CAAAGUGAUGAGUAAUACUGGCUG - 74
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 20459774
   Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls
   Witten D, Tibshirani R, Gu SG, Fire A, Lui WO
   BMC Biol (2010) 8:58