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12 publications mentioning dme-mir-13b-2

Open access articles that are associated with the species Drosophila melanogaster and mention the gene name mir-13b-2. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 45
Among 154 coexpressed miRNAs, five mature miRNAs (dme-miR-1008-5p, dme-miR-133-3p, dme-miR-137-3p, dme-miR-13b-3p, dme-miR-932-5p) were differentially expressed between PD and control groups (p<0.05) (Table 2 and S5 Table). [score:5]
Among the dysregulated miRNAs, miR-13b, miR-133 and miR-137 were highly conserved from Drosophila to H. sapiens and their expression was validated by qRT-PCR. [score:4]
We found that five miRNAs (dme-miR-133-3p, dme-miR-137-3p, dme-miR-13b-3p, dme-miR-932-5p, dme-miR-1008-5p) were upregulated in PD flies. [score:4]
Our study using high throughput sequencing of miRNAs identified miR-13b, miR-133, miR-137, miR-932 and miR-1008 consistently upregulated in early stage PD flies. [score:4]
As four of the dysregulated miRNAs in PD flies including dme-miR-133-3p, dme-miR-137-3p, dme-miR-13b-3p and dme-miR-932-5p were brain enriched, we predicted targets of them and then submit to DAVID for Gene Ontology analysis (Fig 6 and S7 Table). [score:4]
Previously, we found miR-13b was also upregulated in adult onset AD flies [59]. [score:4]
Lgr3 (Relaxin receptor) and AR2 (Galanin receptor) were predicted to be targeted by miR133-3p and miR-13b-3p respectively. [score:3]
MiR-13b’s human homologue is miR-499 [57] that expressed in brain region and its polymorphism is associated with ischemic stroke [58]. [score:3]
The dashed circles indicated 6 miRNAs that were significantly differentially expressed (dme-mir-13b-1 and dme-mir-13b-2 shares the same mature sequence dme-miR-13b-3p). [score:3]
qRT-PCR were performed to validate the expression of dme-miR-13b-3p, dme-miR-133-3p and dme-miR-137-3p in control and PD flies. [score:3]
0137432.g005 Fig 5 qRT-PCR were performed to validate the expression of dme-miR-13b-3p, dme-miR-133-3p and dme-miR-137-3p in control and PD flies. [score:3]
Using high throughput small RNA sequenceing technology, we measured miRNA expression profiles of early stage PD flies and identified five dysregulated mature miRNAs (miR-13b, dme-miR-133, dme-miR-137, miR-932 and miR-1008). [score:2]
Among them, dme-miR-133-3p, dme-miR-137-3p and dme-miR-13b-3p (the mature sequence both for dme-mir-13b-1 and dme-mir-13b-2) were highly conserved from flies to humans and enriched in nervous system. [score:1]
These results indicate that miR-13b/miR-499 play important roles in pathogenesis of brain insults. [score:1]
Among them, miR-13b, miR-133, miR-137 are brain enriched and highly conserved from Drosophila to Homo sapiens. [score:1]
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[+] score: 17
mir-2 and mir-13 repress translation of the target genes, grim, skl and rpr, suggesting that they may be involved in regulating apoptosis [48]. [score:6]
bmo-miR-281a, bmo-miR-281a*, bmo-miR-281b*, bmo-miR-13b and bmo-miR-2b were expressed most strongly in larva, although they were also expressed in pupa and moth. [score:5]
Genes in the cluster containing bmo-miR-2a-1/bmo-miR-2a-1*/bmo-miR-2a-2/bmo-miR-2b/bmo-miR-13a*/bmo-miR-13b are members of the mir-2 miRNA family. [score:1]
4220] of these six genes can bind perfectly to mir-2 (bmo-miR-2a, bmo-miR-2b, bmo-miR-13a* and bmo-miR-13b) and bmo-miR-7, respectively. [score:1]
Searching the D. melanogaster and A. gambiae miRNAs, we found that corresponding mir-2 and mir-13 family members also assembled into clusters in these two species. [score:1]
Examining the positions of the identified miRNAs in the B. mori genome, we identified two miRNA clusters (Figure 4): bmo-miR-2a-1/bmo-miR-2a-1*/bmo-miR-2a-2/bmo-miR-2b/bmo-miR-13a*/bmo-miR-13b; and bmo-miR-275/bmo-miR-305/bmo-miR-305*. [score:1]
bmo-miR-2b, which is found in the gene cluster bmo-miR-2a-1/bmo-miR-2a-1*/bmo-miR-2a-2/bmo-miR-2b/bmo-miR-13a*/bmo-miR-13b, encodes a newly identified member of the mir-2 family. [score:1]
a. bmo-miR-2a-1/bmo-miR-2a-1*/bmo-miR-2a-2/bmo-miR-2b/bmo-miR-13a*/bmo-miR-13b; b. bmo-miR-275/bmo-miR-305/bmo-miR-305*. [score:1]
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[+] score: 10
Therefore, feeding of the DCPTN-PT containing culture media did not depress the regulatory microRNAs (miR-2, miR-13 and miR-14) that control the translation of three pro-apoptotic host genes (miR-2 and miR-13 targets rpr, grim and miR-14 targets Drice), suggesting that DCPTN-PT compound is not an inhibitor of all proapoptotic genes but very specific to oncomiR bantam. [score:10]
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[+] score: 7
In some cases, we observed no effect on normal miRNA homeostasis (for example, miR-9b), in other cases a significant decrease in the abundance of mature target miRNAs was apparent (for example, miR-8 and miR-13b) (Fig. 1b). [score:3]
These included miR-SPs targeting bantam, miR-1, the K-box family (miR-2b, miR-2c and miR-13b displayed strong phenotypes; miR-2a and miR-13a were flight impaired but fell below our stringent cutoff; ), miR-7, the miR-31 family, miR-34, miR-190, miR-957, miR-986, miR-987 and miR-1001. [score:3]
Supporting this argument, several hits in the viability screen belonged to the K-box family (miR-2a, miR-2b and miR-2c, and miR-13a and miR-13b) and the miR-9 family (miR-9b and miR-9c). [score:1]
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[+] score: 5
mir-995 cdc2c Yes mir-11/998 E2f Yes mir-92a jigr1 Yes mir-999 CASK Yes mir-281-1/281-2 Oda Yes mir-970 Tomosyn Yes mir-2b-2/2a-1/2a-2 spi Yes mir-13b-2 CG7033 Yes mir-9c/306/79/9b grpYes [a] mir-33 HLH106 No expression information mir-1012 Lerp No expression information mir-1010 SKIP No a Detected in the oocyte. [score:5]
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[+] score: 3
In the 13b~2c cluster a wrong conclusion of a lack of correlation of dme-mir-13b-1 to dme-mir-13a and dme-mir-2c can be formally deduced due to the superposition of the expression of the non-clustered paralog dme-mir-13b-2 with identical sequence. [score:3]
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[+] score: 2
A cluster of miR-2a-1, miR-2a-2, miR-2b, miR-13a and miR-13b is localized on chromosome 1 of B. mori, indicating there are two precursors of miR-2a, and miR-2a-2 is in the interior of this cluster. [score:1]
By searching bmo-miR-2a in Silkworm Genome Database, it is noticed that there are two precursors of pre-bmo-miR-2a which localized on chromosome 1 and organized as a cluster with pre-miR-2b, pre-miR-13a and pre-miR-13b (Figure 5). [score:1]
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[+] score: 2
Two of the five clusters, mir-13b-1/mir-13a/mir-2c and mir-2a-2/mir-2a-1/mir-2b-2, are derived from a single ancestral mir-2/mir-13 cluster (48, 49). [score:1]
All members of the mir-2/mir-13 ancestral cluster belong to the same family (the mir-2 family), suggesting that the ancestral cluster originated by tandem duplication. [score:1]
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[+] score: 1
However, the fourth one included two microRNAs, mir-2a-1 and mir-13b-2, which are female-biased. [score:1]
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[+] score: 1
For sickle we found one conserved site in all flies for miR-2, miR-13, and miR-6, which share the same nucleus. [score:1]
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[+] score: 1
The cluster (sfr-mir-2a, sfr-mir-2b, sfr-mir-2c, sfr-mir-13a, sfr-mir-13b) is distributed over the region, 8161–8774 of scaffold 1973 with a size of 20411bp (Fig. 3B, i), while the other (sfr-mir-10494, sfr-mir-10463, sfr-mir-10471) span over 10636bp region of scaffold 6745. [score:1]
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[+] score: 1
In D. melanogaster, the proapoptotic K-box miRNA mir-2, and mir-13 occur jointly. [score:1]
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