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16 publications mentioning gga-mir-34a

Open access articles that are associated with the species Gallus gallus and mention the gene name mir-34a. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 60
Although there were no SE genes regulated by mir-34a predicted, the down-regulation of miR-34a may conduce to B cell development in the response to SE infection in chickens. [score:6]
Bcl-2 and the Foxp1 transcription factor, which were required for early B cell development [44], are the direct target of miR-34a, so it was hypothesized that miR-34a plays an important role in B cell development [45– 47]. [score:6]
MiR-34a-5p was down-regulated and potentially targeted 46 immune-related genes in chicken after SE infection. [score:5]
It has been reported that mir-34a exclusively expressed in AIV infected chicken lung with targeting 14 immune-related genes and four AIV genes [29]. [score:5]
MiR-34a was associated with the cellular senescence, it was strongly up-regulated and targeted the important proto-oncogene MYC during B-RAF -induced senescence [42]. [score:5]
MiRNAs in group one showed higher expression in the N group but lower expression in I group, which including gga-miR-34a-5p, gga-miR-215-5p, and gga-miR-1662. [score:5]
The regulatory direction of gga-miR-1416-5p, gga-miR-1662, and gga-miR-34a-5p were opposite with the target genes of TLR21, BCL10, TLR1LA, NOTCH2 and THBS1, respectively. [score:5]
The gga-miR-34a-5p, gga-miR-1416-5p and gga-miR-1662 could play important roles in SE infection through regulating their target genes. [score:4]
The gga-miR-125b-5p, gga-miR-34a-5p, gga-miR-1416-5p and gga-miR-1662 could play an important role in SE infection through regulating their target genes. [score:4]
The gga-miR-1662 and gga-miR-34a-5p were down-regulated after SE infection. [score:4]
MiR-34a may play an important role in the loss of oxidative defense in rat liver during aging through suppressing the expression of Sirt1, Mgst1, Sp1 and Nrf2 [43]. [score:4]
MiR-34a causes a partial block in B cell development, whereas its knockdown results in increased B cells development in rat bone marrow [48]. [score:3]
CCL4, IL8L1 and CDC42 were contained in the Salmonella infection pathway and were all targeted by miR-34a. [score:3]
Gga-miR-34a-5p interacted with the greatest number of immune-related genes (46), while the gga-miR-215-5p only interacted with one immune-related gene. [score:1]
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[+] score: 21
For example, the gga-miR-34a, which was only expressed in infected chicken lungs, not only had 14 immune related target genes (Additional file 2: Table S2), but also targeted the AIV HA, NA, PA, PB1 and PB2 genes. [score:7]
Most of the up-regulated miRNAs were predicted to target the hemaglutinin (HA) and neuraminidase (NA) mRNAs such as miR-34a and miR-155. [score:6]
A comprehensive analysis combining both miRNA and targeted mRNA gene expression suggests that gga-miR-34a, 122–1, 122–2, 146a, 155, 206, 1719, 1594, 1599 and 451, and MX1, IL-8, IRF-7, TNFRS19 are strong candidate miRNAs or genes involved in regulating the host response to AIV infection in the lungs of broiler chickens. [score:6]
Specifically, this study generated a list of strong candidate miRNAs including miR-34a, 122–1, 122–2, 146a, 155, 206, 1719, 1594, 1599 and 460 that potentially regulate AIV infection in chickens. [score:2]
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[+] score: 17
Previous studies reported that the mir-34 family was identified as a p53 target and a potential tumor suppressor to regulate processes, such as proliferation, cell cycle, apoptosis and metastasis [94– 100]. [score:6]
The miR-34 family was significantly differentially expressed between LP and HP chickens in the two tissues. [score:3]
However, the contrary expression pattern between pituitary and hypothalamus tissues indicates that the different members of miR-34 family play different roles in the two tissues in the egg-laying process. [score:3]
In the present study, gga-miR-34 were significantly differentially expressed between LP and HP chickens, suggesting that gga-miR-34 has an important impact on reproductive process of hens. [score:3]
Some studies also observed that miR-34 can regulate age -associated events and long-term brain integrity to modulate aging and neurodegeneration in Drosophila [101]. [score:2]
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[+] score: 13
2 ERBB4 1.4 gga-miR-34a-5p −2.4 Table 7 MiRNA-mRNA pairs with inverse expression relationship between the L2 and N1 groups GeneLog [2]FC miRNALog [2]FC Biological process JAK3 1.34 gga-miR-365-2-5p −1.99 Cell differentiation PDLIM4 1.20 gga-miR-365-2-5p −1.99 Limb development LIMD1 1.14 gga-miR-365-2-5p −1.99 Negative regulation of osteoblast differentiation CDK6 1.12 gga-miR-365-2-5p −1.99 UPK1B 1.14 gga-miR-365-2-5p −1.99 Epithelial cell differentiation The feathering phenotype is a sex-linked trait and can be utilized to distinguish the sexes at hatching based on differences in the rate of feather growth between primary and primary-covert feathers. [score:5]
2 ERBB4 1.4 gga-miR-34a-5p −2.4 Table 7 MiRNA-mRNA pairs with inverse expression relationship between the L2 and N1 groups GeneLog [2]FC miRNALog [2]FC Biological process JAK3 1.34 gga-miR-365-2-5p −1.99 Cell differentiation PDLIM4 1.20 gga-miR-365-2-5p −1.99 Limb development LIMD1 1.14 gga-miR-365-2-5p −1.99 Negative regulation of osteoblast differentiation CDK6 1.12 gga-miR-365-2-5p −1.99 UPK1B 1.14 gga-miR-365-2-5p −1.99 Epithelial cell differentiation The small and long RNA sequencing provided by Illumina technology generated an average of 16–19 million single-end high-quality reads and 65–69 million paired-end high-quality reads from each sample. [score:5]
In addition, gga-miR-34a-5p and gga-miR-365-2-5p nearly participated in nearly all these processes by targeting 12 and 11 genes, respectively. [score:3]
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[+] score: 12
Recent studies show that members of this family, miRNA-34a-c, are direct transcriptional targets of p53, and participate in the suppression of cell proliferation [35, 36]. [score:6]
Ecdysone and Broad-Complex are responsible for the down-regulation of miR-34 in the development of Drosophila [34]. [score:5]
In fact, miR-34 is highly conserved, and its homologs have been wi dely identified in several other species across phyla. [score:1]
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[+] score: 12
MiR-34a regulates hepatic levels of PPARA expression, and silencing miR-34a increases expression of PPARα-regulated genes [41]. [score:7]
MiR-1, miR-206, miR-613, and miR-34a repress expression of lipogenic genes in the human hepatocyte cell line HepG2 by suppression of nuclear transcription factors such as LXRα (miR-1, miR-206, miR-613) [30, 31] and RXRα (miR-34a) [32]. [score:5]
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[+] score: 9
MiR-4510 inhibited the growth of HCC-derived Huh7 and Hep3B cells and of HBL-derived Huh6 cells (which carry a missense G34V mutation in β-catenin/CTNNB1 gene) and it was significantly more effective than miR-34a-5p in Hep3B cells (Figure 6A). [score:4]
Figure 6MiR-4510 acts as a tumor suppressor in vitro (A) Six days after transfection, the effect of miR-4510 and miR-34a-5p on the growth of Huh7, Hep3B and Huh6 cells was compared using the Sulforhodamine B colorimetric assay (Abs 492nm). [score:1]
It induced proliferation arrest and apoptosis in all tested cell lines more efficiently than miR-34a-5p, the first miRNA -mimic tested in clinic. [score:1]
For instance MRX34, a synthetic encapsulated form of miR-34a-5p, is currently tested for the treatment of primary adult liver cancer [17, 18]. [score:1]
Moreover, it induced apoptosis in the three hepatoma cell lines tested while miR-34a-5p had no pro-apoptotic effect (Figure 6B). [score:1]
MiR-34a-5p, which constitutes a miRNA mimic encapsulated in ionizable liposomes (MRX34), is being tested since spring 2013 in a multicentric clinical trial [24]. [score:1]
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[+] score: 6
Other miRNAs from this paper: hsa-mir-34a
In rat mo dels [15], upregulation of miR-34a-5p led to cell cycle arrest at G [0]G [1] phases via inhibiting cell cycle-related genes (CCND1, CCNE2 and MET) after exposed to AFB [1]. [score:6]
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[+] score: 6
Previous studies have suggested that members of the miR-34 family may act as tumor suppressors (He et al., 2007; Hermeking, 2010). [score:3]
MiR-34b-5p is a member of the miR-34 family. [score:1]
The miR-34 family in cancer and apoptosis. [score:1]
However, most previous studies have been focused on two other members of this family, miR-34a and miR-34c. [score:1]
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[+] score: 4
We reported the involvement of several miRNAs including miR-34a [9, 10] and miR-221 [11] in JNK-regulated chondrogenic differentiation. [score:2]
Our laboratory also showed that JNK signaling is involved in the differentiation of chondroprogenitors in chicks through regulation of miR-34a [9, 10] and miR-221 levels [11]. [score:2]
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[+] score: 3
The reproducibility of these results was tested by Taqman RT-PCR, selecting 18 miRNAs (hsa-let-7a, hsa-miR-141, hsa-miR-143, hsa-miR-145, hsa-miR-17, hsa-miR-182, hsa-miR-191, hsa-miR-199a-5p, hsa-miR-200a, hsa-miR-200b, hsa-miR-222, hsa-miR-29b, hsa-miR-34a, hsa-miR-424, hsa-miR-15a, hsa-miR-199a-3p, hsa-miR-26b, hsa-miR-361-3p) previously showing at least a three-fold modulation in expression in a wide panel of PDAC cell lines 49. [score:3]
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[+] score: 2
As shown in Fig. 4, gga-miR-221, gga-miR-125b, gga-miR-211, gga-miR-222a, gga-miR-193b, gga-miR-148a, gga-miR-27b, gga-miR-34a and gga-miR-130a were quantified by qRT-PCR, and these results were consistent with the sequencing analysis. [score:1]
gga-miR-221, gga-miR-222, gga-miR148, gga-miR-27b, gga-miR-34a and gga-miR-130a, which are related to differentiation and maturation, could also further influence the function of mature DCs. [score:1]
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[+] score: 2
Other miRNAs from this paper: hsa-let-7d, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-21, hsa-mir-22, hsa-mir-30a, hsa-mir-32, hsa-mir-33a, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-147a, hsa-mir-34a, hsa-mir-187, hsa-mir-204, hsa-mir-205, hsa-mir-200b, hsa-mir-23b, hsa-mir-30b, hsa-mir-125b-1, hsa-mir-138-2, hsa-mir-142, hsa-mir-144, hsa-mir-125b-2, hsa-mir-138-1, hsa-mir-146a, hsa-mir-190a, hsa-mir-200c, hsa-mir-155, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-30e, hsa-mir-365b, hsa-mir-328, gga-mir-33-1, gga-mir-125b-2, gga-mir-155, gga-mir-17, gga-mir-148a, gga-mir-138-1, gga-mir-187, gga-mir-32, gga-mir-30d, gga-mir-30b, gga-mir-30a, gga-mir-30c-2, gga-mir-190a, gga-mir-204-2, gga-mir-138-2, gga-let-7d, gga-let-7f, gga-mir-146a, gga-mir-205b, gga-mir-200a, gga-mir-200b, gga-mir-30e, gga-mir-30c-1, gga-mir-205a, gga-mir-204-1, gga-mir-23b, gga-mir-142, hsa-mir-449a, hsa-mir-489, hsa-mir-146b, hsa-mir-548a-1, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-33b, hsa-mir-449b, gga-mir-146b, gga-mir-147, gga-mir-489, gga-mir-449a, hsa-mir-449c, gga-mir-21, gga-mir-144, gga-mir-460a, hsa-mir-147b, hsa-mir-190b, gga-mir-22, gga-mir-460b, gga-mir-1662, gga-mir-1684a, gga-mir-449c, gga-mir-146c, gga-mir-449b, gga-mir-2954, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az, gga-mir-365b, gga-mir-33-2, gga-mir-125b-1, gga-mir-190b, gga-mir-449d, gga-mir-205c
And in this study, we found more than one miRNA, including miR-142-5p, miR-32-5p, miR-1662, miR-155, miR-30e-5p and miR-34a-5p, that function together to target LRP1B in the pulmonary arteries of AS broilers, which was characterized by vascular cells proliferation. [score:1]
Nonetheless, miR-142-3p, miR-449-5p, miR-148a-5p, miR-365b-5p, miR-200-3p, miR-34a-5p and miR-1443-3p found in our results have few reported associations to PAH. [score:1]
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[+] score: 1
Other miRNAs from this paper: gga-mir-34b, gga-mir-34c, gga-mir-101-1, gga-mir-101-2
11, 17, 18, 19 A perfect example of miRNA replacement therapy is MRX34, a liposome -based miR-34 mimic who has became the first miRNA to enter phase I clinical trials in 2013 (http://clinicaltrials. [score:1]
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[+] score: 1
miR-34 is the first miR replacement therapy in clinical trials by the company Mirna Therapeutics, with let-7 in the pipeline [35]. [score:1]
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[+] score: 1
Several miRNAs (gga-miR-125b-5p, gga-miR-34a-5p, gga-miR-1416-5p, and gga-miR-166) associated with SE infection were identified recently in laying chicken cecum by next generation sequencing (Wu et al., 2017). [score:1]
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