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1 publications mentioning dre-mir-301bOpen access articles that are associated with the species Danio rerio and mention the gene name mir-301b. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary. |
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Other miRNAs from this paper: dre-mir-219-1, dre-mir-219-2, dre-let-7a-1, dre-let-7a-2, dre-let-7a-3, dre-let-7a-4, dre-let-7a-5, dre-let-7a-6, dre-let-7b, dre-let-7c-1, dre-let-7c-2, dre-let-7d-1, dre-let-7d-2, dre-let-7e, dre-let-7f, dre-let-7g-1, dre-let-7g-2, dre-let-7h, dre-let-7i, dre-mir-9-1, dre-mir-9-2, dre-mir-9-4, dre-mir-9-3, dre-mir-9-5, dre-mir-9-6, dre-mir-9-7, dre-mir-130a, dre-mir-130b, dre-mir-130c-1, dre-mir-130c-2, dre-mir-142a, dre-mir-142b, dre-mir-144, dre-mir-146a, dre-mir-153c, dre-mir-190a, dre-mir-219-3, dre-mir-301a, dre-mir-301c, dre-mir-459, dre-let-7j, dre-mir-735
Totally, the final results included 9 downregulated miRNAs (dre-miR-142a-3p, dre-miR-142b-5p, dre-miR-144-3p, dre-miR-146a, dre-miR-190a, dre-miR-219-5p, dre-miR-301b-3p, dre-miR-459-5p and rno-miR-33-5p) and 3 upregulated miRNAs (dre-miR-735-3p, dre-miR-735-5p and mmu-miR-6240).
[score:7]
In general, dre-miR-301b, -142a, -144, and rno-miR-33, were highly focused in network of downregulated miRNAs, while dre-miR-735 and mmu-miR-6240 were in network of upregulated miRNAs.
[score:7]
MiR-301 also regulated the expression of key proteins involved in cholesterol homeostasis and blood lipid levels [27], consistent with what was indicated in S3 Fig. Although the research realm of miR-142a centered on cardiovascular and immune system [28, 29], evidences suggested its renal -associated actions [30].
[score:4]
One of them, miR-301b, belonged to miR-130 family, which was regarded as an oncogene and abnormally expressed in lung, breast and many other cancers [24– 26].
[score:3]
The utmost concern about miR-33 was its ability to regulate cellular cholesterol transport and maintain plasma HDL levels [32], which highly related with the physiological role of miR-301b.
[score:2]
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