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16 publications mentioning ssc-mir-140

Open access articles that are associated with the species Sus scrofa and mention the gene name mir-140. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 47
MiR-122 was specifically expressed in liver (A), and miR-140-3p, -720, -2861, and -3149 were highly expressed in heart (B to E). [score:5]
MiR-122 was specifically expressed in liver, and miR-140-3p, -720, -2861, and -3149 were highly expressed in heart. [score:5]
Further origin identification revealed that the expression levels of miR-122 in CECs and lymphocytes, miR-140-3p and -2861 in monocytes and CECs, miR-720 in monocytes, and miR-3149 in CECs were greatly up-regulated in the ACS patients compared with the non-ACS patients, and were higher as well in the AMI patients than that in the UA patients except for the miR-122 in CECs (all P < 0.05). [score:5]
The results showed that miR-122 was specifically expressed in liver, and miR-140-3p, -720, -2861, and -3149 were highly expressed in heart (Fig 1). [score:5]
Abbreviations: CECs = circulating endothelial cells, other abbreviations as in Fig 3. Furthermore, compared with the UA patients, the expression levels of miR-140-3p (Ct [UA] = 23.0±0.6, Ct [AMI] = 22.0±0.6), -720 (Ct [UA] = 22.6±0.5, Ct [AMI] = 22.2±0.5), and -2861 (Ct [UA] = 23.0±0.9, Ct [AMI] = 22.3±1.1) in monocytes (Fig 4B), and the expression levels of miR-122 (Ct [UA] = 35.1±0.7, Ct [AMI] = 34.4±0.6), -140-3p (Ct [UA] = 31.9±0.6, Ct [AMI] = 31.2±0.8), -2861 (Ct [UA] = 23.5±1.3, Ct [AMI] = 23.1±1.1), and -3149 (Ct [UA] = 12.0±0.3, Ct [AMI] = 11.2±0.4) in CECs (Fig 4D) were significantly increased in the AMI patients (all P < 0.05). [score:4]
MiR-140 is expressed in numerous tissues and cell types including brain, breast, lung, colon, ovary and testis, and acts as a potential tumor suppressor in cutaneous squamous cell carcinoma, basal cell carcinoma, osteosarcoma, ovarian cancer, colon cancer, lung squamous cell carcinoma, and breast cancer [40]. [score:4]
Abbreviations: CECs = circulating endothelial cells, other abbreviations as in Fig 3. Furthermore, compared with the UA patients, the expression levels of miR-140-3p (Ct [UA] = 23.0±0.6, Ct [AMI] = 22.0±0.6), -720 (Ct [UA] = 22.6±0.5, Ct [AMI] = 22.2±0.5), and -2861 (Ct [UA] = 23.0±0.9, Ct [AMI] = 22.3±1.1) in monocytes (Fig 4B), and the expression levels of miR-122 (Ct [UA] = 35.1±0.7, Ct [AMI] = 34.4±0.6), -140-3p (Ct [UA] = 31.9±0.6, Ct [AMI] = 31.2±0.8), -2861 (Ct [UA] = 23.5±1.3, Ct [AMI] = 23.1±1.1), and -3149 (Ct [UA] = 12.0±0.3, Ct [AMI] = 11.2±0.4) in CECs (Fig 4D) were significantly increased in the AMI patients (all P < 0.05). [score:4]
In addition, the expression levels of miR-140-3p, -720, and -2861 in monocytes (B), and miR-122, -140-3p, -2861, and -3149 in CECs (D) were higer in the AMI patients than that in the UA patients. [score:3]
The expression levels of miR-140-3p, -720, and -2861 in monocytes (A), miR-122, -140-3p, -2861, and -3149 in CECs (C), and miR-122 in lymphocytes (E) were dramatically increased in the ACS patients in contrast to the non-ACS patients. [score:3]
Our study demonstrated that the expression levels of miR-140-3p, -720, and -2861 in monocytes of the ACS patients were significantly higher than that in the non-ACS patients, suggesting that these miRNAs were originated from the activated monocytes during ACS, and these miRNAs have the potential to be biomarkers for ACS diagnosis and deserve further study. [score:3]
Therefore, these studies suggest that miR-140-3p and -2861 are highly expressed in both endothelial cells and monocytes/macrophages. [score:3]
MiR-140-3p has been reported to be highly expressed in blood of the CHD patients [41] and in PBMCs of the diabetes mellitus patients [42]. [score:2]
Our study found that miR-122 and -3149 were mainly released by endothelial cells, miR-720 was mainly come from monocytes, and miR-140-3p and -2861 were originated from both endothelial cells and monocytes. [score:1]
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2
[+] score: 11
A study on the expression profile of novel miRNAs in 11 pig tissues, including brain, liver, heart, muscle, colon, kidney, lung, spleen, stomach, cervix and fibroblasts, indicated that ssc-miR-15b, ssc-miR-23a, ssc-miR-23b, ssc-miR-24, ssc-miR-29a, ssc-miR-30b, ssc-miR-145, and ssc-miR-152 are expressed in all tissues; ssc-miR-210 is mainly expressed in the liver, spleen, and stomach; ssc-miR-34a and ssc-miR-130a are mainly expressed in the lungs; and ssc-miR-140 is highly expressed in the cervix. [score:11]
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3
[+] score: 7
Five upregulated (miR-146a-5p, miR-146b, miR-365-3p, miR-92a, and miR-181c) and five downregulated (miR-30b-3p, miR-214, miR-140-3p, miR-664-3p, and miR-1307) miRNAs from the microarray were selected randomly to conduct real-time PCR. [score:7]
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4
[+] score: 6
For example, the significantly differentially expressed miRNAs, miR-9, miR-9–1 and miR-9–2 all target IL12A, but the immune-related gene IL7R was individually regulated by miR-140–3p. [score:6]
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5
[+] score: 5
Liu et al. showed that miR-140 is a facilitator of adipocyte lineage commitment [2], whereas several other groups found that miR-27 can suppress the terminal differentiation of preadipocytes by targeting the adipogenic master gene, peroxisome proliferator-activated receptor γ (PPARγ) and prohibitin [3, 4]. [score:5]
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6
[+] score: 5
In mouse cells, the cartilage specific miRNA, miR-140, targets the histone deacetylase 4 (HDAC4), suggestive of a role in long bone development [20]. [score:4]
These include miR-214, miR-140, miR-150, miR-10, as well as miR-181. [score:1]
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7
[+] score: 4
miR-140 is a facilitator of adipocyte lineage commitment, and it promotes fat deposition via down-regulation of osteopetrosis -associated transmembrane protein 1 (OSTM1), which is an anti-adipogenic factor [14]. [score:4]
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8
[+] score: 4
In our experiments, the miR-140-5p (annotated as miR-140) has much lower abundance (in total of 23 counts) than miR-140-3p (annotated as miR-140*, in total of 33 K counts) (Table S6). [score:1]
There is only one known porcine pre-miRNA (mir-140) which codes for two miRNAs. [score:1]
The latest miRBase 14.0 (September 2009) reports total 10,883 pre-miRNAs, but only 77 of these pre-miRNAs are from pig, which code for 72 distinct miRNAs and one miRNA* (miR-140*-3p), which originates from the hairpin pre-miRNA arm opposite to the annotated miRNA containing arm [11]. [score:1]
Specifically, 11 miRNAs and one miRNA* (miR-140*-3p) are known in miRBase, and seven were not previously identified (and thus new) porcine miRNA*s (Tables S6 and S7); (3) 186 miRNAs corresponding to 139 other known miRBase mammalian pre-miRNAs which are mapped to the genome or EST. [score:1]
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9
[+] score: 3
Additionally, looking at normalised counts for each breed (Table S6), there were some miRNAs with low frequency which their expression was higher in some breed, such as Hsa-miR-193b-5p, Hsa-miR-140-5p, Ssc-miR-19b, Ssc-miR-423-5p and Ssc-miR-24 in Iberian breed, Ssc-miR-151-5p, Hsa-miR-4454, Ssc-miR-199a-3p and Ssc-miR-374b-5p in Landrace breed, Ssc-miR-486 in Piétrain breed and Ssc-let-7f and Hsa-let-7i-5p in Meishan breed. [score:3]
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10
[+] score: 3
SNPs (ASGA0036064) regulating the transcription of TTC8 in cis action also regulate miR-99a, miR-425-9p, miR-130b, miR-98, miR-140 in trans-action. [score:3]
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11
[+] score: 2
One example is ssc-miR-140*. [score:1]
This miRNA* sequence read number was 8483, which is much higher than that of ssc-miR-140 (the read number of miR-140 was only 4), indicating that miRNA* might be the functional form in pigs (Table S1). [score:1]
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12
[+] score: 2
Using miRNA microarray analysis and RT-PCR, some researchers have found that miR-24, miR-31, miR-140, miR-141, miR-205, miR-200c, miR-875-5p, miR-455, miR-689, miR-711, and miR-720 may regulate tooth epithelial stem cell differentiation [6], [7]; others identified miR-133a, miR-200b, miR-206, and miR-218 as tooth-specific miRNAs, and that miR-141, miR-199b*, miR-200a, miR-200b, miR-200c, and miR-429 likely play a role in the renewal and differentiation of adult stem cells during stem cell-fueled incisor growth [8], [9]. [score:2]
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13
[+] score: 1
Other miRNAs from this paper: ssc-mir-122, ssc-mir-135-1, ssc-mir-135-2, ssc-mir-148a, ssc-mir-19a, ssc-mir-20a, ssc-mir-224, ssc-mir-24-1, ssc-mir-323, ssc-mir-183, ssc-mir-214, ssc-mir-27a, ssc-mir-325, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-103-1, ssc-mir-107, ssc-mir-136, ssc-mir-153, ssc-mir-18a, ssc-mir-186, ssc-mir-196a-2, ssc-mir-204, ssc-mir-21, bta-mir-18b, bta-let-7f-2, bta-mir-101-2, bta-mir-103-1, bta-mir-148a, bta-mir-18a, bta-mir-20a, bta-mir-21, bta-mir-221, bta-mir-27a, bta-mir-27b, bta-mir-107, bta-mir-140, bta-mir-20b, bta-mir-215, bta-let-7d, bta-mir-17, bta-mir-186, bta-mir-199b, bta-mir-210, bta-mir-214, bta-mir-450a-2, bta-let-7g, bta-mir-24-2, bta-let-7a-1, bta-let-7f-1, bta-mir-122, bta-let-7i, bta-let-7a-2, bta-let-7a-3, bta-let-7b, bta-let-7c, bta-let-7e, bta-mir-103-2, bta-mir-15a, bta-mir-19a, bta-mir-204, ssc-mir-15a, ssc-mir-17, ssc-mir-199b, ssc-mir-210, ssc-mir-221, bta-mir-101-1, bta-mir-133a-2, bta-mir-133a-1, bta-mir-135a-2, bta-mir-135a-1, bta-mir-135b, bta-mir-136, bta-mir-146b, bta-mir-153-1, bta-mir-153-2, bta-mir-183, bta-mir-24-1, bta-mir-196a-2, bta-mir-196a-1, bta-mir-196b, bta-mir-224, bta-mir-323, ssc-mir-101-1, ssc-mir-101-2, ssc-mir-133a-1, ssc-mir-450a, ssc-mir-146b, ssc-mir-215, bta-mir-1343, bta-mir-2320, bta-mir-2326, bta-mir-2366, bta-mir-2411, bta-mir-2483, bta-mir-450a-1, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-103-2, ssc-mir-27b, ssc-mir-24-2, ssc-mir-196b-1, ssc-mir-450b, ssc-mir-450c, ssc-mir-133a-2, ssc-let-7a-2, ssc-mir-18b, ssc-mir-1343, ssc-mir-2320, bta-mir-450b, ssc-let-7d, ssc-let-7f-2, ssc-mir-20b-1, ssc-mir-20b-2, ssc-mir-196a-1, ssc-mir-196b-2, ssc-mir-2366-1, ssc-mir-2366-2, ssc-mir-2411, ssc-mir-2483
A number of miRNAs (miR-136, miR-140, miR-204, miR-221, and miR-325) originated from the 5′ and 3′ arms of the miRNA hairpin precursors, exhibited a similar number of sequence reads. [score:1]
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14
[+] score: 1
miR-140-3p has been reported to be increased in CHD [21]. [score:1]
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15
[+] score: 1
Among the 40 DEMs obtained by deep sequencing, 8 (miR-100, miR-140, miR-184, miR-193a-5p, miR-222, miR-4332-3p, miR-451, and miR-574) were detectable in microarray. [score:1]
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16
[+] score: 1
Several miRNAs (i. e., let-7f, miR-21, miR-140, miR-185, miR-320, miR-423, miR-2476-1, miR-2476-2 and miR-2476-3) are indicated with arrows. [score:1]
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