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11 publications mentioning hsa-mir-526a-2

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-526a-2. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 52
Other miRNAs from this paper: hsa-mir-146a, hsa-mir-526a-1
Targets Viral Proteins Antagonizing Approach RIG-I EV-A71 3C Impeding ofinteraction between RIG-I and MAVS[26] CV-B3 3C Cleavage[56] PV 3C Cleavage[56, 70] Rhinovirus 16 3C Cleavage[70] Echovirus 3C Cleavage[70] MDA-5 EV-A71 induced caspases Cleavage[57] PV induced caspases Degradation in proteasome- and caspase -dependent manner[71] EV-A71 2A Cleavage[56] CV-B3 2A Cleavage[56] PV 2A Cleavage[56] MAVS EV-A71 2A Cleavage[28, 56] PV2A Cleavage[56] PV induced caspases Cleavage[72] CV-B3 3C Cleavage[73] CV-B3 2A Cleavage[56] HRV1a 2A, 3C and caspases Cleavage[74] TRIF EV-A71 3C Cleavage[75] EV-D68 3C Cleavage[76] CV-B3 3C Cleavage[73] IRF7 EV-A71 3C Cleavage[77] EV-D68 3C Cleavage[78] IRF9 EV-A71 3C Cleavage[79] IKKβ EV-A71 2C Inhibition of phosphorylation[80] P65 EV-A71 2C Inhibition of interaction between P65 and P50[81] TAK1 Complex EV-A71 3C Cleavage of TAK1/TAB1/TAB2/TAB3[82] IFANR1 EV-A71 2A Down-regulation[83] G3BP1 CV-B3 3C Cleavage[84] miR-146a EV-A71 Upregulation of miR-146a to inhibit IRAK1- and TRAF6 -mediated IFNβ production[85] miR-526a EV-A71 3C Downregulation[86] Figure 1 Evasion of PRRs -mediated signaling pathways by EVs. [score:18]
Targets Viral Proteins Antagonizing Approach RIG-I EV-A71 3C Impeding ofinteraction between RIG-I and MAVS[26] CV-B3 3C Cleavage[56] PV 3C Cleavage[56, 70] Rhinovirus 16 3C Cleavage[70] Echovirus 3C Cleavage[70] MDA-5 EV-A71 induced caspases Cleavage[57] PV induced caspases Degradation in proteasome- and caspase -dependent manner[71] EV-A71 2A Cleavage[56] CV-B3 2A Cleavage[56] PV 2A Cleavage[56] MAVS EV-A71 2A Cleavage[28, 56] PV2A Cleavage[56] PV induced caspases Cleavage[72] CV-B3 3C Cleavage[73] CV-B3 2A Cleavage[56] HRV1a 2A, 3C and caspases Cleavage[74] TRIF EV-A71 3C Cleavage[75] EV-D68 3C Cleavage[76] CV-B3 3C Cleavage[73] IRF7 EV-A71 3C Cleavage[77] EV-D68 3C Cleavage[78] IRF9 EV-A71 3C Cleavage[79] IKKβ EV-A71 2C Inhibition of phosphorylation[80] P65 EV-A71 2C Inhibition of interaction between P65 and P50[81] TAK1 Complex EV-A71 3C Cleavage of TAK1/TAB1/TAB2/TAB3[82] IFANR1 EV-A71 2A Down-regulation[83] G3BP1 CV-B3 3C Cleavage[84] miR-146a EV-A71 Upregulation of miR-146a to inhibit IRAK1- and TRAF6 -mediated IFNβ production[85] miR-526a EV-A71 3C Downregulation[86] Figure 1 Evasion of PRRs -mediated signaling pathways by EVs. [score:18]
Xu C. He X. Zheng Z. Zhang Z. Wei C. Guan K. Hou L. Zhang B. Zhu L. Cao Y. Downregulation of microRNA miR-526a by enterovirus inhibits RIG-I -dependent innate immune response J. Virol. [score:6]
However, in later stages of EV-A71 infection, the 3C proteinase can block the expression of miR-526a and further inhibit IFN production. [score:5]
3C also inhibits miR-526a -mediated RIG-I activation. [score:3]
Recently, Xu et al. [86] showed that RIG-I signaling pathway can be positively regulated by EV-A71 -induced miR-526a. [score:2]
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2
[+] score: 20
Interferon regulatory factors can mediate the upregulation of miR-526a, which further targets Cylindromatosis (turban tumor syndrome), also known as CYLD, a well-known deubiquitinase, to enforce K63-linked RIG-I ubiquitination and then triggers IRF3 and NF-κB signaling. [score:7]
EV71 3C protease cleaves host Interferon regulatory factor 7 (IRF7) to block IRF -mediated miR-526a upregulation and then suppresses RIG-I -dependent IFNs production [70]. [score:7]
Xu C. He X. Zheng Z. Zhang Z. Wei C. Guan K. Hou L. Zhang B. Zhu L. Cao Y. Downregulation of microRNA miR-526a by enterovirus inhibits RIG-I -dependent innate immune response J. Virol. [score:6]
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3
[+] score: 16
The expression of miRNAs had been reported to be altered during EV71 infection in vitro; miR-526a and miR-146a that target the RIG-I -dependent innate immune response and the IRAK1 pathway respectively, were both up-regulated upon EV71 infection, thus inhibiting type I interferon production, facilitating further EV71 infection (Ho et al., 2011; Xu et al., 2014). [score:10]
Downregulation of microRNA miR-526a by enterovirus inhibits RIG-I -dependent innate immune response. [score:6]
[1 to 20 of 2 sentences]
4
[+] score: 15
It was also observed that RIG-I activity was downregulated by enterovirus 71 though virus -mediated decrease of miR-526a and increased expression of its target cylindromatosis (CYLD), a negative regulator of RIG-I activity [90]. [score:9]
Xu C. He X. Zheng Z. Zhang Z. Wei C. Guan K. Hou L. Zhang B. Zhu L. Cao Y. Downregulation of microRNA miR-526a by enterovirus inhibits RIG-I -dependent innate immune response J. Virol. [score:6]
[1 to 20 of 2 sentences]
5
[+] score: 12
Other miRNAs from this paper: hsa-mir-526a-1
Xu C. He X. Zheng Z. Zhang Z. Wei C. Guan K. Hou L. Zhang B. Zhu L. Cao Y. Downregulation of MicroRNA miR-526a by enterovirus inhibits RIG-I-Dependent innate immune response J. Virol. [score:6]
The 3C [pro] of EV71 downregulates miR-526a to suppress the RIG-I -dependent innate immune response [121]. [score:6]
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6
[+] score: 7
miR-522, miR-139-3p, miR-520c-5p, miR-518d-5p, miR-146b-5p, miR-34a, miR-526a, miR-193a-3p, miR-221, miR-4674 were significantly upregulated and miR-760 was downregulated in ECSCs (Figure 2A). [score:7]
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7
[+] score: 4
Hromadnikova et al. reported an upregulation of circulating C19MC miRNAs (miR-516-5p, miR-517*, miR-520a*, miR-525, and miR526a) in patients with PE (33). [score:4]
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8
[+] score: 4
Specifically, amounts of hsa-miR-526a and hsa-miR-527 are dramatically higher in the sera of third trimester pregnant women (elevated by more than 600 fold). [score:1]
A) The three placental microRNAs (miR-527, miR-520d-5p and miR-526a) are highly abundant in the sera of pregnant women and their levels rise as pregnancy progresses. [score:1]
Indeed, we found that the levels of three placental microRNAs (hsa-miR-526a, hsa-miR-527 and hsa-miR-520d-5p) could be used to accurately distinguish pregnant from non pregnant women (Figure 5). [score:1]
The y axis indicates the amount of mir-527, and the x axis indicates the average level of miR-520d-5p and miR-526a. [score:1]
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9
[+] score: 2
There is some probability for hsa-mir-526a and hsa-mir-211 to be involved in regulating metabolite processes, but more data are needed to make more clear predictions. [score:2]
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10
[+] score: 1
For example, circulating miRNAs were found in the sera of pregnant women [27]: miRNA-526a, miRNA-527 and miRNA-520d-5p showed a considerably high fold-change and could be used to distinguish pregnant from non-pregnant women with high accuracy. [score:1]
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11
[+] score: 1
A significant elevation of several extracellular placenta-specific miRNA levels was recently showed (miR-516-5p, miR-517, miR-518b, miR-520a, miR-520h, miR-525, and miR-526a,) during early gestation in 7 pregnancies with later onset of preeclampsia and/or FGR [44]. [score:1]
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