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17 publications mentioning mmu-mir-484

Open access articles that are associated with the species Mus musculus and mention the gene name mir-484. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 42
Although the 8 miRNAs we performed RT-qPCR validation were all up-regulated in disease EPCs, surprisingly only miR-361-5p and miR-484 were consistently more abundant in the plasma of CAD patients. [score:6]
Suppression levels of miR-361-5p, not miR-484, restored VEGF expression and EPC functions. [score:5]
To over-express or knock down miR-361-5p and miR-484 in EPCs, agomir or antagomir were added into culture medium at a concentration of 50 nM at 70% to 80% cell confluence. [score:4]
miR-361-5p, but not miR-484, regulates EPC function via targeting VEGF. [score:4]
Knock down of miR-361-5p, but not miR-484, in CAD-EPCs to a level compatible to that in healthy EPCs by oligonucleotide antagomirs restored VEGF expression (Fig. 3D and Fig. S1B). [score:4]
Overexpression of miR-361-5p, but not miR-484, resulted in the reduction of VEGF transcripts in healthy EPCs (Figs. 3A–B). [score:3]
MicroRNA-484 directly targets VEGFB and VEGFR2, thereby defining chemoresistance in ovarian cancer through modulation of tumor vasculature [36]. [score:3]
Figure S1 miR-361-5p, not miR-484, regulates EPC angiogenic activities via down -regulating VEGFA level. [score:3]
Consistently, EPC motility was only inhibited in PB-EPCs transfected with miR-361-5p, but not those with miR-484 (Figs. 3B–C and Fig. S1A). [score:3]
, Guangzhou, China) for miR-361-5p or miR-484 are commercial synthetic RNA molecules with several chemical modifications for direct transfection without transfect reagents. [score:2]
miR-361-5p, but not miR-484, regulates EPC function via targeting VEGFWe then investigated the effects of miR-361-5p and miR-484 on VEGF levels and EPC activities. [score:2]
However, miR-484 did not affect VEGF levels in EPC (Fig. 3). [score:1]
Here we show that miR-361-5p and miR-484 secreted by CAD-EPCs are more abundant in patient plasma (Fig. 2). [score:1]
Further exploration of their levels in the plasma of CAD patient and control cases, only circulating miR-361-5p and miR-484 were more abundant in CAD cases by RT-qPCR (Fig. 2D). [score:1]
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[+] score: 32
Some miRNAs were overexpressed in tumors (miR-155, miR-193b, miR-27a, miR-31, miR-99b, miR-484, miR-574-3p, miR-125a-5p, miR-182), whereas others displayed down-regulation (miR-20a, miR-200c, miR-93, miR-340-5p, miR-720) or a comparable level of expression (miR-200a) with respect to non tumor tissues. [score:8]
MiR-340-5p, miR-484, miR-574-3p, and miR-720 showed fluctuant levels of slight down-regulation or over -expression during the treatment. [score:6]
The above-mentioned miRs appear to be up- (miR-484 and miR-574-3p) or down-regulated (miR-340-5p, miR-720) in tumor tissues. [score:4]
Significant miR-484 level increase was described in sera from early breast cancer [74] and in melanoma [75], whereas miR-484 down-regulation was displayed in urine from prostate cancer patients [76]. [score:4]
Among them, miR-340-5p, miR-484, miR-574-3p, miR-720, whose expression was never described in NAFLD, NASH and HCC tissues, and miR-125a-5p and miR-182, which showed early and significant dysregulation in the sequential hepatic damage process. [score:4]
No data are reported about the expression and role of miR-340-5p, miR-484, miR-574-3p, and miR-720 in NAFLD, NASH and HCC tissues. [score:3]
Four dysregulated microRNAs (miR-340-5p, miR-484, miR-574-3p, miR-720), never described in liver damage and tumorigenesis, were here detected. [score:2]
Zearo S Kim E Zhu Y Zhao JT Sidhu SB Robinson BG MicroRNA-484 is more highly expressed in serum of early breast cancer patients compared to healthy volunteersBMC Cancer. [score:1]
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[+] score: 21
The non-significant results in cortex, cerebellum and liver in Series 2 may be due to the lack of Q175 samples in Series 2. Interestingly, Mir484 has been implicated in suppressing translation of mitochondrial fission protein FIS1 and inhibited FIS1 -mediated fission and apoptosis in cardiomyocytes and adrenocortical cancer cells [27]. [score:6]
Using the 6- and 10-month meta-analysis statistics, we found a single microRNA, Mir484, that is differentially expressed (downregulated with increasing CAG length) across all 5 tissues in Series 1 and striatum in Series 2 at the p<0.05 threshold and changes in the same direction with Q across all 9 data sets (in Series 2 cortex and liver, the p-values are below 0.1 (suggestive) but above 0.2 in series 2 cerebellum). [score:6]
Elife 4. 27 Wang K, Long B, Jiao JQ, Wang JX, Liu JP, et al (2012) miR-484 regulates mitochondrial network through targeting Fis1. [score:4]
Further studies are needed to determine whether the decreased expression of Mir484 alters Fis1 levels in different brain regions in HD knockin mice and contributes to dysregulated mitochondrial dynamics in HD cells [28, 29]. [score:4]
Consistent with the notion that microRNA responses are broadly distinct across all four brain regions, we only identified three microRNAs (Mir484, Mir212, and Mir6944) that are commonly dysregulated across all 4 brain regions. [score:1]
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[+] score: 6
Statistical data analysis revealed that the mean expression level of 9 miRNAs (i. e. ; miR-128, miR-99b-5p, miR-130b-3p, miR-142-3p, miR-374a-5p, miR-423-5p, miR-484, miR-629-5p, let-7d-3p) was significantly different (student t-test p<0.05) across the studied groups (Table 2). [score:3]
Altered expressions of miR-629a-5p, let-7d-3p, miR-142-3p and miR-484 were not confirmed in the whole cohort (p<0.05). [score:3]
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[+] score: 5
The relative LINC01088 expression was normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and the relative miR-24-1-5p expression was normalized to miR-484, and analysed by the 2 [−ΔΔCt] method. [score:5]
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[+] score: 4
Other miRNAs from this paper: mmu-mir-16-1, mmu-mir-16-2, mmu-mir-574
miR-484 has been reported to regulate mitochondrial fission [45], and mitochondrial fission is involved in oxidative stress, apoptosis, and many neurological diseases. [score:4]
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[+] score: 4
Li T. Ding Z. L. Zheng Y. L. Wang W. MiR-484 promotes non-small-cell lung cancer (NSCLC) progression through inhibiting Apaf-1 associated with the suppression of apoptosisBiomed. [score:4]
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[+] score: 4
To further assess the alterations of mitochondria-related miRNAs in obesity, we examined the expression levels of miR-126a-3p, miR-141-3p, miR-196a-5p, miR-210-3p, miR-378a-3p, miR-484 and miR-499a-5p in mice livers. [score:3]
There was no significant difference of miR-126a-3p, miR-484, miR-499a-5p between HFD mice and SD mice. [score:1]
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[+] score: 4
Vecchione et al. [33] found that miR-484 was associated with chemoresistance in ovarian cancer and determined that the sensitive phenotype is a result of modulation of the tumor vasculature through the regulation of the VEGFB and VEGFR2 pathways, rather than through the inhibition of apoptosis. [score:4]
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[+] score: 3
The remaining eighteen differentially regulated miRNAs identified in the present study (miR-484, miR-677-3p, miR-690, miR-709, miR-1839-3p, miR-1902, miR-2137, miR-3077-5p, miR-3084-3p, miR-3090-5p, miR-3096b-3p, miR-3102-5p, miR-5627-5p, miR-6239, miR-6240, miR-6244, miR-6402, and miR-6538) have not previously been associated with ionizing radiation. [score:2]
Eighteen miRNAs found in the present study have not previously been associated with ionizing radiation, i. e. miR-484, miR-677-3p, miR-690, miR-709, miR-1839-3p, miR-1902, miR-2137, miR-3077-5p, miR-3084-3p, miR-3090-5p, miR-3096b-3p, miR-3102-5p, miR-5627-5p, miR-6239, miR-6240, miR-6244, miR-6402, and miR-6538. [score:1]
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[+] score: 3
In addition to those high-level miRNAs, many miRNAs from other cell components of the blood were among the top 100, such as miR-223-3p, miR-146a-5p, miR-150-5p, myeloid cell specific miRNAs [9], and miR-484, which was the most abundantly expressed miRNA in platelets [19] (Supplementary Table 2). [score:3]
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[+] score: 3
Five additional miRNAs (miR-664-3p, miR-592-5p, miR-484, miR-687 and miR-192-5p) showed expression differences which were close to significance (significance cut-off: p < 0.002). [score:3]
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[+] score: 2
Our analysis also suggests that 6 DEmiRs, miR-17-5p, miR-486b-5p, miR-19a-3p, miR-484, miR-199a-5p and miR-182-5p, are likely to be co-regulated by both Ctcf and Spi1. [score:2]
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[+] score: 2
On the other hand, mutation of Tarbp2 rescued levels of miR-127 and miR145 to wild-type levels, but had no effect on miR-120 and actually resulted in an increase in two miRNAs, let-7e and miR-484, that had been unaffected in wild-type MEFs. [score:2]
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[+] score: 1
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-18a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-20a, hsa-mir-22, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-98, hsa-mir-101-1, hsa-mir-16-2, mmu-let-7g, mmu-let-7i, mmu-mir-1a-1, mmu-mir-15b, mmu-mir-101a, mmu-mir-126a, mmu-mir-130a, mmu-mir-133a-1, mmu-mir-142a, mmu-mir-181a-2, mmu-mir-194-1, hsa-mir-208a, hsa-mir-30c-2, mmu-mir-122, mmu-mir-143, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-181a-1, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-15b, hsa-mir-122, hsa-mir-130a, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-142, hsa-mir-143, hsa-mir-126, hsa-mir-194-1, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-208a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-15a, mmu-mir-16-1, mmu-mir-16-2, mmu-mir-18a, mmu-mir-20a, mmu-mir-22, mmu-mir-26a-1, mmu-mir-26b, mmu-mir-29c, mmu-mir-98, mmu-mir-326, rno-mir-326, rno-let-7d, rno-mir-20a, rno-mir-101b, mmu-mir-101b, hsa-mir-1-1, mmu-mir-1a-2, hsa-mir-181b-2, mmu-mir-17, mmu-mir-19a, mmu-mir-181a-1, mmu-mir-26a-2, mmu-mir-19b-1, mmu-mir-181b-1, mmu-mir-181c, hsa-mir-194-2, mmu-mir-194-2, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-101-2, hsa-mir-26a-2, hsa-mir-378a, mmu-mir-378a, hsa-mir-326, mmu-mir-133a-2, mmu-mir-133b, hsa-mir-133b, mmu-mir-181b-2, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-15b, rno-mir-16, rno-mir-17-1, rno-mir-18a, rno-mir-19b-1, rno-mir-19a, rno-mir-22, rno-mir-26a, rno-mir-26b, rno-mir-29c-1, rno-mir-30c-1, rno-mir-30c-2, rno-mir-98, rno-mir-101a, rno-mir-122, rno-mir-126a, rno-mir-130a, rno-mir-133a, rno-mir-142, rno-mir-143, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-194-1, rno-mir-194-2, rno-mir-208a, rno-mir-181a-1, hsa-mir-423, hsa-mir-18b, hsa-mir-20b, hsa-mir-451a, mmu-mir-451a, rno-mir-451, ssc-mir-122, ssc-mir-15b, ssc-mir-181b-2, ssc-mir-19a, ssc-mir-20a, ssc-mir-26a, ssc-mir-326, ssc-mir-181c, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-18a, ssc-mir-29c, ssc-mir-30c-2, hsa-mir-484, hsa-mir-181d, hsa-mir-499a, rno-mir-1, rno-mir-133b, mmu-mir-20b, rno-mir-20b, rno-mir-378a, rno-mir-499, hsa-mir-378d-2, mmu-mir-423, mmu-mir-499, mmu-mir-181d, mmu-mir-18b, mmu-mir-208b, hsa-mir-208b, rno-mir-17-2, rno-mir-181d, rno-mir-423, rno-mir-484, mmu-mir-1b, ssc-mir-15a, ssc-mir-16-2, ssc-mir-16-1, ssc-mir-17, ssc-mir-130a, ssc-mir-101-1, ssc-mir-101-2, ssc-mir-133a-1, ssc-mir-1, ssc-mir-181a-1, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-378-1, ssc-mir-133b, ssc-mir-499, ssc-mir-143, ssc-mir-423, ssc-mir-181a-2, ssc-mir-181b-1, ssc-mir-181d, ssc-mir-98, ssc-mir-208b, ssc-mir-142, ssc-mir-19b-1, hsa-mir-378b, ssc-mir-22, rno-mir-126b, rno-mir-208b, rno-mir-133c, hsa-mir-378c, ssc-mir-194b, ssc-mir-133a-2, ssc-mir-484, ssc-mir-30c-1, ssc-mir-126, ssc-mir-378-2, ssc-mir-451, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, mmu-mir-378b, mmu-mir-101c, hsa-mir-451b, hsa-mir-499b, ssc-let-7a-2, ssc-mir-18b, hsa-mir-378j, rno-mir-378b, mmu-mir-133c, mmu-let-7j, mmu-mir-378c, mmu-mir-378d, mmu-mir-451b, ssc-let-7d, ssc-let-7f-2, ssc-mir-20b-1, ssc-mir-20b-2, ssc-mir-194a, mmu-let-7k, mmu-mir-126b, mmu-mir-142b, rno-let-7g, rno-mir-15a, ssc-mir-378b, rno-mir-29c-2, rno-mir-1b, ssc-mir-26b
Sharbati-Tehrani et al., [67] have reported 4 new miRNAs (miR-326, miR-423-3p, miR-484 and miR-451,) that could not be identified in our study, which could be attributed to the use of very specialized tissues (Jejunium, spleen, ileum and kidney) for their study. [score:1]
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[+] score: 1
miR-466d-5p + + ND miR-484 +miR-484 was involved in adrenal tumorigenesis [60]. [score:1]
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[+] score: 1
Here, 15 miRNAs (miR-let-7e*, miR-15a*, miR-19b-1*, miR-30e*, miR-130b*, miR-149, miR-296-5p, miR-362-5p, miR-378, miR-425, miR-432, miR-484, miR-574-3p, miR-671-5p, and miR-1249) established interactions with 19 mRNAs. [score:1]
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