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6 publications mentioning mmu-mir-592

Open access articles that are associated with the species Mus musculus and mention the gene name mir-592. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 27
Other miRNAs from this paper: mmu-mir-21a, mmu-mir-23a, mmu-mir-27a, mmu-mir-21b, mmu-mir-21c
Previous miRNA microarray analysis has demonstrated that miR-552 and miR-592 were an oncomir and up-regulated of in CRC [30, 31, 33, 35, 36]. [score:4]
Several lines of evidence have demonstrated that ADAMs could be regulated by miRNAs in various cancers [27– 29], and we and others have recently revealed a strikingly up-regulated miR-552 and miR-592 in CRC tissues as compared to the matched adjacent non-tumor tissues, which imply the it may play a oncogenic role in CRC tumorigenesis [30, 31] and metastasis [32, 33]. [score:4]
In addition, all examined CRC cell lines, including HCT116, LOVE, LS174T and SW480, also showed an elevated expression of miR-552 and miR-592 in comparison with the normal colon epithelial cell line CCD-18Co (Figure 1C). [score:3]
Figure 1(A) Relative expression of miR-552 and miR-592 in CRC tissues. [score:3]
In line with the previous reports from other groups, results of this study also displayed a significantly more abundant miR-552 and miR-592 transcripts in tumor tissues relative to the matched adjacent non-tumor tissues (Figure 1A and Table 1), and the expression of miR-552 was also correlated with the abundance of miR-592 transcript in CRC tissues (r = 0.3568, 95% CI = 0.079–0.583, p < 0.011, N = 50) (Figure 1B). [score:3]
In order to further validate a correlation of the expression of these miRNAs and clinicopathologic stages in CRC, the relative expression of miR-552 and miR-592 in CRC tumor tissues and cell lines was evaluated by a qRT-PCR assay (Figure 1 and Table 1). [score:2]
Both miR-552 and miR-592 expression is significantly elevated in CRC tissues as compared with the matched adjacent non-tumor tissues (p < 0.001). [score:2]
Relative miR-552 and miR-592 expression in tumor tissues compared to the matched adjacent non-tumor tissues of various stages of colorectal cancer. [score:2]
Evoked miR-552 and miR-592 transcripts in human colorectal cancer. [score:1]
In the present study, we identified miR-552 and miR-592 were potential oncogenes in CRC, in which both miR-552 and miR-592 were significantly evoked in CRC, which were correlated with the TNM stages and lymph node metastasis of this type of cancer. [score:1]
As aberrant miR-21 and miR-592 seen in CRC, more abundant miR-27a transcript was detected in specimens from glioblastoma comparing with normal human brain tissues. [score:1]
Aberrant miR-552 and miR-592 transcripts in colorectal cancer tissues and cell lines. [score:1]
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[+] score: 27
Therefore the diet-independent downregulation of miR-592 in PPARγ DN animals indicates that miR-592 expression is directly or indirectly (if e. g. co-expressed as an intronic miRNA within the transcript of a PPARγ-responsive host gene) driven by PPARγ. [score:10]
Interestingly, only four of the 21 regulated miRNAs (miR-199a, miR-455, miR-592, and miR-1192) were solely dependent on the genotype; independent of diet, the expression of miR-199a, miR-455 and miR-1192 was up-regulated in PPARγ DN animals whereas miR-592 was down-regulated in these mice compared to wt. [score:9]
The expression of four miRNAs was only dependent on the PPARγ expression status of the animals; miR-199, miR-455 and miR-1192 were upregulated in mice with dominant -negative PPARγ irrespective of the diet given to the animals, the fourth, miR-592, was reduced in mutant animals (“a” in Fig. 5C). [score:8]
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[+] score: 7
The upregulated miRNAs included mmu-miR-34a-5p, mmu-miR-129b-5p, mmu-miR-451a, mmu-miR-144-5p and mmu-miR-129b-3p, whereas highly downregulated miRNAs included mmu-miR-100-5p, mmu-miR-99a-5p, mmu-miR-33-5p, mmu-miR-125a-5p, mmu-miR-128-1-5p, mmu-miR-181b-1-3p, mmu-miR-188-5p, mmu-miR-196b-5p, mmu-miR-211-5p, mmu-miR-224-5p, mmu-miR-455-3p, mmu-miR-504-5p, mmu-miR-592-5p, mmu-miR-5107-3p, mmu-miR-5120, and mmu-let-7i-3p. [score:7]
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[+] score: 3
The 10 most inhibited miRNAs are miR-1a, miR-133a/b, miR-196a, miR-206, miR-208b, miR-211, miR-592, miR-653, and miR-1963. [score:3]
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[+] score: 3
Five additional miRNAs (miR-664-3p, miR-592-5p, miR-484, miR-687 and miR-192-5p) showed expression differences which were close to significance (significance cut-off: p < 0.002). [score:3]
[1 to 20 of 1 sentences]
[+] score: 2
We also observed an increase of miR-592-5p with age in df/df but not in N mice. [score:1]
In addition, serum miR-592-5p was increased in df/df mice with age but did not change in N mice [28]. [score:1]
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