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8 publications mentioning mmu-mir-680-3

Open access articles that are associated with the species Mus musculus and mention the gene name mir-680-3. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 13
There were four up-regulated miRNAs (mmu-miR-709, mmu-miR-467a-3p, mmu-miR-182-5p and mmu-miR-25-5p) and seven down-regulated miRNAs (mmu-miR-615-3p, mmu-miR-409-3p, mmu-miR-680, mmu-miR-129-5p, mmu-miR-151-5p, mmu-miR-142-5p and mmu-miR-30b-5p), as the values presented in Table 1. Then we performed unsupervised hierarchical clustering of the eleven miRNAs. [score:7]
Control) P -valuemmu-miR-25-5p2.210.04mmu-miR-7091.980.02mmu-miR-467a-3p1.820.04mmu-miR-182-5p1.540.05mmu-miR-129-5p0.290.02mmu-miR-6800.340.02mmu-miR-615-3p0.360.00mmu-miR-409-3p0.440.02mmu-miR-30b-5p0.510.05mmu-miR-151-5p0.610.03 mmu-miR-142-5p 0.63 0.04By TargetScan, we found that mmu-miR-25-5p, mmu-miR-615-3p, mmu-miR-151-5p and mmu-miR-680 had few target genes directly relating with Tregs in MeSH database, so we excluded the four miRNAs for further exploration. [score:6]
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[+] score: 9
Of the seven upregulated miRNAs, three (miR-680, miR-320 and miR-22) were confirmed to be upregulated by qRT-PCR analysis (Supplemental Figure 2A). [score:7]
We analyzed the levels of 13 miRNAs confirmed to be dysregulated in P7 Ercc1 [−/−] MEFs compared to P3 Ercc1 [−/−] MEFs (miR-680, miR-320, miR-22, miR-449a, miR-455*, miR-675-3p, miR-128, miR-497, miR-543, miR-450b-3p, miR-872, miR-369-5p and miR-10b) in RNA samples prepared from the livers of WT young (20 weeks), the progeroid Ercc1 [−/Δ] mice, and WT old mice (30 months). [score:1]
Three miRNAs (miR-680, miR-320, and miR-22) which were upregulated in P7 compared to P3 Ercc1 [−/−] MEFs (Table 4) as measured by microarray did not show upregulation in livers from progeroid and WT old mice compared to young WT controls as measured by qRT-PCR (data not shown). [score:1]
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[+] score: 5
Pattern 3 and 4 were unique to Group B (increased miR-10b and decreased miR-680, respectively); Pattern 5 was common to both Groups B and C and contained 29 miRNAs whose expression was increased; and Pattern 6 was comprised of 35 Group C miRNAs whose expression was likewise increased. [score:5]
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[+] score: 4
The top-ten upregulated transcripts in Akita hearts are 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), natriuretic peptide receptor-3 (NPR3), uncoupling protein-1 (UCP1), microRNA-680 (miR-680), angiopoietin-like 4 (ANGPTL4), mitochondrially encoded cytochrome c oxidase-1 (MT-CO1), spermiogenesis specific transcript on the Y-1 (Ssty1), sycp3 like Y-linked (Sly), vomeronasal-1receptor-180 (Vmn1r180) and microRNA-101c (miR-101c) (Fig 3C). [score:4]
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[+] score: 2
In order to validate the expression of these genes, we performed real-time RT-PCR (except for Mir680-3, because it is a micro -RNA). [score:2]
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[+] score: 1
Moreover, miR-680 showed the highest fold change (Fold change = 20.92, Table  4) following long-term smoking. [score:1]
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[+] score: 1
Additionally, selected miRs that were significantly altered in our microarray, such as miR-26b, miR-27a, miR-143, miR-150, miR-328, miR-341*, miR-680 and miR-1224, were validated. [score:1]
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[+] score: 1
On the other hand, by RNA ISH we obtained a clear regional hybridization signal for 14 miRNAs that were not detected in a reliable manner by microarray profiling (e. g. miR-188-5p, miR-296-5p, miR-680, miR-681; see database). [score:1]
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