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10 publications mentioning mmu-mir-721

Open access articles that are associated with the species Mus musculus and mention the gene name mir-721. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 21
Specifically, PI3K/AKT/mTOR signaling may be altered by the up-regulation of miR-721 and the down-regulation of its target, the tumor suppressor protein Tsc1, which has been associated with impairments in the migration and developmental positioning of pyramidal neurons in the hippocampus leading to cognitive function, learning, and memory deficits (Orlova and Crino, 2010; Mejia et al., 2013). [score:12]
Treatment days miRNAExpression change [#] Predicted mRNA target(s)Expression change [#]GD 8/11 [†] miR-1192 ↑ Atf1, Gng4, Map3k1, Rpe, Setd2, Stxbp6, Zc3h6 ↓ miR-532-5p ↑ Atf1, Itpripl2, Stxbp6 ↓GD 14/16 [*] miR-10b ↓ Aak1 ↑ miR-184 ↓ Myl9 ↑ miR-302c ↑ Ccdc6, Mfap3, Ptpro, Rnd3, Rpl36a/r, Sema3c, Stoml3, Supt3h ↓ miR-342-5p ↓ Aak1, Cables2, Rhog ↑ miR-343 ↑ Asic4, Dcn, Gpr116, Ptpro, Stoml3 ↓ miR-449b ↓ Ina ↑PD 4/7 [†] miR-26b ↑ Adam9, Chsy1, Cnr1, Exoc8, Hs6st1, Lingo1, Map3k7, Mras, Pfkfb3, Ppm1b, Rhou, Sema6d, Shank2, Tab3, Tdrd7, Ube2j1 ↓ miR-34b-5p ↓ Kitl ↑ miR-184 ↑ Ncor2, Prkcb ↓ miR-721 ↑ Akap11, B4galt, Cnr1, Efnb2, Fam20b, Ino80, Irf1, Lrrk2, Ncoa3, Pfkfb3, Ppargc1a, Rbm9, Shank2, Spen, Sphk2, Tsc1, Wdfy3 ↓ miR-1970 ↓ Arhgap6 ↑ # Significance for expression change was 1.2-fold, p < 0.05. [score:9]
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[+] score: 18
Seven conserved DE miRs are upregulated during pneumonia and are expressed at moderate to high levels in lung neutrophils (average normalized mean expression above 5): mmu-miR-1224-5p, mmu-miR-188-5p, mmu-miR-139-5p, mmu-miR-15b-5p, mmu-miR-721, mmu-miR-18a-5p, and mmu-miR-130b-3p. [score:8]
We identified a network containing seven upregulated conserved miRs (mmu-miR-1224-5p, mmu-miR-188-5p, mmu-miR-139-5p, mmu-miR-15b-5p, mmu-miR-721, mmu-miR-18a-5p and mmu-miR-130b-3p) and another network consisting of downregulated miRs belonging to 3 highly conserved miR families (let-7, mir-30 and mir-34). [score:7]
Two of these, mmu-miR-721 and mmu-miR-130b-3p, belong to the same broadly conserved miR family and are therefore predicted to share target mRNAs in common. [score:3]
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[+] score: 13
The mature and e-miR-721* are predicted to target appreciable numbers of genes involved in cardiovascular disease, unlike the novel generic miR*, suggesting a reason for the processing of the e-miR-721* to be favored in cardiomyocytes (Figure 5D). [score:5]
Furthermore, there is much greater sequence identity across species for e-miR-721* than mature miR-721, suggesting this to be the more important miR-721 variant expressed at this locus (data not shown). [score:3]
As an indication of the biological significance of e-miR-721*, we performed gene function analysis with the predicted targets of the three miR-721 hairpin-derived miRNAs. [score:3]
e-miR-721* is the most abundant non-generic miRNA in the cardiomyocyte and heart biopsy datasets (Figure 5C). [score:1]
Left, hairpin fold as listed in miRbase; right, hypothetical alternative fold consistent with canonical processing of miR-721 together with the novel e-miR-721*. [score:1]
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[+] score: 8
Leishmania (Leishmania) amazonensis induces macrophage miR-294 and miR-721 expression and modulates infection by targeting NOS2 and L-arginine metabolism. [score:5]
L. amazonensis infection increased the expression of some macrophage miRNAs, such as miR-294 and miR-721. [score:3]
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[+] score: 7
Other miRNAs from this paper: mmu-mir-125a, mmu-mir-125b-2, mmu-mir-125b-1
We examined two microRNAs (mir-125 and miR-721) expressed during preimplantation [32] and four RNA polymerase III dependent transcripts, major vault protein (Mvp), U6 small nuclear RNA (Rnu6), and two small nucleolar RNAs [Snord110 and Snord65 [33], [34]]. [score:3]
Real-time RT-PCR was performed using 0.75 embryonic equivalents with Taqman probe based gene expression assays from Applied Biosystems as follows: 2X Quanta PerfeCTa Supermix Low ROX, 20X Vic-labeled ActB (#4352341E) or GapD (#4352339E), 20X Gene Expression Assay (Bax Mm00432050_m1; miR-125 TM002198; miR-721- #TM001657; Oct4 Mm00658129_gH; Tead4 Mm01189836_m1; Trp53 Mm01731287; Wdr36 Mm00620161_m1; Wdr74 Mm00506573_m1; Rnu6 TM1973; Sno110 TM1230. [score:3]
E. Relative levels of microRNAs miR-125 and miR-721 and RNA polymerase III derived transcripts, Mvp, Rnu6, Snord110 and Snord65 in dsGFP and dsWdr74 morula. [score:1]
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[+] score: 5
Leishmania (Leishmania) amazonensis induces macrophage miR-294 and miR-721 expression and modulates infection by targeting NOS2 and L-arginine metabolism. [score:5]
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[+] score: 5
Only 15 miRNAs from the 64 DEMs had validated target genes in IPA by target filter analysis, including miR-6349, miR-101a-3p, miR-6394, miR-126a-3p, miR-721, miR-143-3p, miR-497a-5p, miR-93-5p, miR-215-5p, miR-199a-3p, miR-23a-3p, miR-27b-3p, miR-2861, miR-30a-5p, and miR-370-3p. [score:5]
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[+] score: 4
In addition, mmu-miR-721 was found to target the mitogen-activated protein kinase 1 (Mapk1), a well-known kinase acting on the intersecting point of various biochemical signalling pathways including differentiation, transcription and development. [score:4]
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[+] score: 3
miRNA Fold change at 3 dpi Fold change at 5 dpi mmu-miR-466h-3p NS (Not significant) 14.311053 mmu-miR-346-5p NS 3.4766614 mmu-miR-877-3p NS 3.416667 mmu-miR-7a-5p NS 2.1413074 mmu-miR-5107-5p NS −2.047792 mmu-miR-3473a −2.2872427 −2.1317267 mmu-miR-150-5p NS −2.1770155 mmu-miR-3473b −3.2475147 −2.282881 mmu-miR-721 NS −2.6864858 mmu-miR-669b-5p NS −2.9408455 mmu-miR-709 NS −3.0065749 mmu-miR-669n NS −3.0094464 mmu-miR-468-3p NS −3.40051 mmu-miR-466m-5p NS −4.33538 mmu-miR-32-3p NS −4.5324426 mmu-miR-466h-5p NS −4.9673104 mmu-miR-3082-5p NS −6.01648 mmu-miR-466i-5p NS −7.6776285 mmu-miR-1187 NS −8.772696 mmu-miR-574-5p NS −9.259378 To confirm the validity of the differentially expressed miRNAs that had been identified by microarray analysis, we performed real-time PCR on all 20 of these miRNAs using the polyA tailing technique. [score:3]
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[+] score: 1
For instance, we identified 5 hub TFs/genes (Rel, Ppp1r9a, Smad7, Ndn, and Cdkn1c) and 10 hub miRNAs (mir-92a-3p, mir-377-3p, mir-17-5p, mir-96-5p, mir-875-3p, mir-875-5p, mir-721, mir-330-3p, mir-20a-5p, and mir-19a-3p) for the monocyte lineage (Figure E in S1 File). [score:1]
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