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2 publications mentioning sme-let-7c

Open access articles that are associated with the species Schmidtea mediterranea and mention the gene name let-7c. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 32
let-7 has been shown to regulate developmental timing in C. elegans through the direct target genes lin-41 and hbl-1 [49]. [score:6]
Finally, we observed a clear positive correlation between the expression of let-7 and its putative target gene vitamin D receptor (VDR, EG_04794) (Figure 5c). [score:5]
Thus, the observation of substantially increased expression of let-7 in the PSC and cyst might be associated with the capability of E. granulosus for bi-directional development, differentiating into an adult worm in the definitive host dog gastrointestinal tract or into a secondary hydatid cyst in the intermediate (or human) host [50]. [score:5]
By comparing the differential expression pattern of miRNAs, our results showed that let-7 exhibited 3.2-fold and 2.6-fold increased expression in PSC and in the cyst, respectively, compared with the adult. [score:4]
Furthermore, through miRNA target prediction analysis, we found let-7 could complementary bind to the VDR 3′ UTR sequences, suggesting that let-7 may mediate a negative feedback loop controlling the bile acid signal pathway in the development of PSC. [score:4]
Here, we observed a positive correlation between the expression of let-7 and VDR, suggesting that VDR may induce crucial miRNA transcriptional events and promote adult development in E. granulosus. [score:4]
Recently, the hormone receptors have been reported to directly activate transcription of the evolutionarily conserved let-7 and control the development of larvae to adults in C. elegans [51]. [score:3]
Recently, a feedback circuit between let-7 -family miRNAs and DAF-12, a homolog of vertebrate FXR and VDR, has been found in C. elegans [52]. [score:1]
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[+] score: 2
Indeed, most recently five miRNAs were found by direct cloning in S. japonicum that are also conserved in S. mansoni [55]: let-7, mir-71, bantam, mir-125, and a single schistosome-specific microRNA. [score:2]
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