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20 publications mentioning hsa-mir-888

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-888. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 52
Of previously predicted mRNA targets of the miR-888 cluster, we found that Spag8 (sperm associated antigen 8) mRNA expression encoding for a human sperm membrane protein (hSMP-1) was significantly and negatively correlated with the expression of miR-892a along the human epididymis (Tables 2 and 3, Fig. S3). [score:7]
Considering the role of Cldn10 in epididymal functions and the presumed importance of cluster miR-888 target genes such as Esrrg, we focused our interest on these two genes and conducted an experimental approach to determine if Cldn10 was regulated by miR-145 and Esrrg by miR-892b. [score:4]
Interestingly, the miR-888 cluster appears to play a prominent role in regulating physiological functions of the human epididymis, owing to its high degree of conservation among primates and absence from other mammalian species, and its predominant expression in the epididymis [42]. [score:4]
Figure S1 Expression level of members of the miR-888 cluster family on microarrays. [score:3]
Interestingly, miRNAs belonging to the miR-888 cluster have been found in primates and their expression is restricted to the epididymis [41], [42]. [score:3]
Members of the miR-888 cluster and miR-215 are differentially expressed in the epididymis. [score:3]
Expression of members of the miR-888 cluster was confirmed by end-point and quantitative PCR (Fig. 4). [score:3]
Furthermore, a mammalian miRNA expression array of 26 distinct organ systems and cell types, showed that miRNAs such as mir-205, and miRNAs belonging to the miR-888 and miR-371 clusters, were significantly enriched in human reproductive systems [41]. [score:3]
Among other target genes of the miR-888 cluster, we identified Crispld1 (Cysteine-rich secretory protein LCCL domain-containing 1), Tmem68 (Transmembrane protein 68), Znf395 (Zinc finger protein 395)(Tables 2 and 3, Fig. S3), Zeb1 (Zinc finger E-box -binding homeobox 1), Aff4 (Major CDK9 elongation factor -associated protein)(Tables 2 and 3, Fig. S4) and Esrrg (Estrogen related receptor Gamma)(Tables 2 and 3, Fig. S3). [score:3]
Expression of the miR-888 cluster family confirmed by end-point and real-time PCR. [score:3]
mir-205 and members of the miR-888 cluster are differentially expressed in the epididymal tubule. [score:3]
Of these, 5 members of the miR-888 cluster (miR-890, miR-891a/b, miR-892a/b) were significantly more abundant in the corpus/cauda regions of the epididymis, suggesting a role in the regulation of the later stages of epididymal sperm maturation. [score:2]
On the basis of small RNA libraries sequenced from 26 distinct organ systems, several miRNAs, including miR-205 and members of the miR-888 and miR-371 clusters, are considered to be expressed primarily in reproductive tissues [41]. [score:2]
In addition, several genes were predicted to be regulated by the miR-888 cluster family. [score:2]
Our results indicate that members of the miR-888 cluster (i. e. miR-890/miR-891a/miR-891b/miR-892a/miR-892b) and miR-205 exhibit significantly lower levels in the caput relative to the corpus, while the levels of the miR-371 cluster did not differ (Fig. 3 A, B and C). [score:1]
0034996.g003 Figure 3 (A) (B) and (C): Dot plots showing the Log 2 signal intensity of miRNAs belonging to the miR-888 and miR-371 cluster families, and miR-205 in the different epididymal regions: caput (cap), corpus (cor) and cauda (cau). [score:1]
In addition, the gene encoding for estrogen-related receptor gamma (Esrrg) was negatively correlated with two members of the miR-888 cluster, miR-892b (Tables 2 and 3, Fig. 6, Fig. S3) and miR-891b (Tables 2 and 3, Fig. S3). [score:1]
However, miR-888 itself did not show any significant variation from one region to another (Fig. 3 A, Fig. S1). [score:1]
Five of six miRNAs located in the miR-888 cluster displayed changes ranging from 1.7-fold for miR-891b to 126-fold for miR-892b, between the caput and the corpus region (miR-890/miR-891a/miR-891b/miR-892a/miR-892b). [score:1]
Confirmation of the microarray data by end-point and quantitative PCR for the miR-888 cluster. [score:1]
For instance, Major CDK9 elongation factor -associated protein (Aff4) and Zinc finger E-box -binding homeobox 1 (Zeb1) were positively correlated with miR-891a and miR-892a respectively, while Estrogen-related receptor gamma (Esrrg), Sperm associated antigen 8 (Spag8), Glycine receptor subunit beta (Glrb), Cysteine-rich secretory protein LCCL domain-containing 1 (Crispld1), Transmembrane protein 68 (Tmem68), and Zinc finger protein 395 (Znf395), were negatively correlated with different members of the miR-888 cluster (Tables 2 and 3, Fig. S3 and S4). [score:1]
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[+] score: 40
The obvious coherent dysregulation of five members of the miR-888 cluster in 13% men with UA and function analysis of their targeted genes suggested that dysregulation of these miRNAs might be an epigenetic basis for some patients with UA. [score:5]
From the 13 cfs-miRNAs previously identified to be predominately derived from the epididymis [21], five miRNAs (miR-891b, miR-892b, miR-892a, miR-888 and miR-890), were significantly down-regulated (P=0.000, 0.001, 0.025, 0.001, 0.000, respectively) in men with UA, as compared with the normozoospermic control donors (Figure 1). [score:3]
Given that the effect of a therapy on sperm motility can usually be observed after one month or more, the recovery of the miR-888 cluster expression would occur at early stage of an effective therapy and be helpful in the prognosis. [score:3]
In spite of great efforts we devoted in investigating inherent regulation of the primate-specific miRNA cluster expression, further studies are hindered by difficulties in obtaining human epididymal tissues or epithelial cells, more studies are needed to shed new light on inherent basis of dysregulation of miR-888 cluster in UA men. [score:3]
To better understand the underlying molecular functions of miR-888 cluster, GO and KEGG pathway analysis subjected to their target genes were performed. [score:3]
Interestingly, obvious coherent dysregulations of five members of this cluster were observed in about 13% patients with UA, levels of miR-891b, miR-888 and miR-890 in these 9 patients with obvious coherent dysregulations of the 5 miRNAs showed stronger correlation with sperm motility. [score:3]
Obvious coherent dysregulations of these miRNAs were present in about 13% UA patients, levels of miR-891b, miR-888 and miR-890 in these 9 patient with obvious coherent dysregulations of the 5 miRNAs showed stronger correlation with sperm motility. [score:3]
The significantly lower levels of miR-888 cluster in seminal plasma of UA patients indicate their dysregulation in the epididymis. [score:2]
The results suggested that levels of miR-891b (A), miR-888 (B), miR-890 (C) and miRNA panel (D) including miR-891b/miR-888/miR-890 in 9 patients with obvious coherent dysregulations of 5 validated miRNAs showed stronger correlation with sperm progressive motility (r=0.726, 0.853, 0.727 and 0.646, p=0.027, 0.003, 0.026 and 0.000, respectively). [score:2]
Given the fact that all UA men recruited in this study were restricted to least disturbance of environmental factors, inherent problem might be the primary cause responsible for dysregulation of miR-888 cluster in UA men. [score:2]
Interestingly, these five dysregulated miRNAs belong to an X-linked epididymis-specific miRNA cluster (miR-888 cluster) [5, 24]. [score:2]
Levels of miR-891b/miR-892b/miR-892a/ miR-888/miR-890 combination (miRNA panel) was also significantly correlated with sperm progressive motility (r=0.218, p=0.000) (F). [score:1]
After identifying 5 members of miR-888 cluster (miR-891b, miR-892b, miR-892a, miR-888 and miR-890) dysregulated in UA patients, we analyzed characteristics of these 5 miRNAs dysregulation in validation set. [score:1]
In summary, our results suggested multiple physiological roles of miR-888 cluster on human epididymis, especially on epididymal sperm maturation. [score:1]
Moreover, levels of miR-891b, miR-888, miR-890 and miRNA panel including miR-891b/miR-888/miR-890 in 9 showed stronger correlation with sperm progressive motility (r=0.726, 0.853, 0.727 and 0.646, p=0.027, 0.003, 0.026 and 0.000, respectively) (Figure 4). [score:1]
Levels of miR-891b/miR-892b/miR-892a/miR-888/miR-890 combination (miRNA panel) was also significantly correlated with sperm progressive motility (r=0.218, p=0.000) (Figure 3F). [score:1]
Genomic location of miR-888 cluster members was shown in Supplementary Figure 1. The green boxplot represent normozoospermia, red boxplot represent asthenozoospermia. [score:1]
The results suggested that miR-891b, miR-892b, miR-892a, miR-888 and miR-890 were correlated with sperm progressive motility separately (r=0.287, 0.395, 0.279, 0.346 and 0.301, p=0.001, 0.000, 0.001, 0.000 and 0.001 respectively) (A-E). [score:1]
In the present study, although levels of the five members of the miR-888 cluster in the group with UA were significantly lower than the normozoospermic group, obvious individual difference was observed in both groups. [score:1]
We found that miRNA level of miR-891b, miR-892b, miR-892a, miR-888 and miR-890 were correlated with sperm progressive motility separately (r=0.287, 0.395, 0.279, 0.346 and 0.301, p=0.001, 0.000, 0.001, 0.000 and 0.001 respectively) (Figure 3A-3E). [score:1]
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[+] score: 8
We were able to identify miR-96, miR-146a, let-7a, 330-3p and miR-888 as being present in significantly higher amounts in AB reticulocytes compared to those from CB and therefore as being potential inhibitors of γ-globin expression. [score:4]
Only five miRNAs - miR-96, miR-888, miR330-3p, let-7a, and miR-146a - were significantly less abundant in CB reticulocytes compared to AB reticulocytes and were also significantly down-regulated in hemin treated K562 cells (Figure 2). [score:3]
Secondly, we report that miRNA-96, miRNA-146a, let-7a, miR-888 and miR-330a-3p are significantly more abundant in reticulocytes obtained from adults than from umbilical cord blood. [score:1]
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[+] score: 7
miR-210, miR-125a-5p, miR-424, miR-181a and miR-23b were most significantly up-regulated in hypoxia -treated HPASMC (Figure 5D), whereas miR-124, miR-888*, miR-541 and miR-223 were the most down-regulated miRNAs (Figure 5E). [score:7]
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[+] score: 7
Overexpression of miR-146a or miR-888—two exogenous miRNAs neither present in the 293T cells nor possess any known target sites on HIV-1 mRNAs—impaired HIV-1 production but did not alter intracellular Gag protein expression, thereby implicating an RNAi-independent mechanism [244]. [score:7]
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[+] score: 6
E3 ligases and deubiquitinases such as MDM2, SMUR1, NEDD4L, NEDD4, RNF41, ITCH, CBL, UBPY, and AMSH were targeted by 9 (hsa-miR-545, hsa-miR-541, hsa-miR-511, hsa-miR-888, hsa-miR-146-5p, hsamiR- 429, hsa-miR-374b, hsa-miR-500, and hsa-miR-656) of the predicted poor prognosis miRs. [score:3]
07] 0.01 1p36.33 hsa-miR-126 −0.36 [−0.64 – −0.08] 0.01 9q34.3 hsa-miR-888 −0.56 [−1.02 – −0.10] 0.02 Xq27.3 hsa-miR-517b −0.22 [−0.41 – −0.03] 0.03 19q13.42 hsa-miR-363 −0.43 [−0.80 – −0.05] 0.03 Xq26.2 hsa-miR-216b −0.26 [−0.50 – −0.03] 0.03 2p16.1 hsa-miR-1285 −0.27 [−0.53 – −0.02] 0.04 7q21. [score:1]
Strikingly, 9 of the poor prognosis associated miRs: hsa-miR-545, hsa-miR-541, hsa-miR-511, hsa-miR-888, hsa-miR-146- 5p, hsa-miR-429, hsa-miR-374b, hsa-miR-500, and hsamiR- 656 have functions in E3 ligases and deubiquitinases (Figure 4B). [score:1]
There were 8 common miRs (hsa-miR-429, hsa-miR-221, hsa-miR- 499-5p, hsa-miR-888, hsa-miR-770-5p, hsa-miR-545, hsa-miR-541, hsa-miR-483-3p) between the two sets of survival -associated miRs (Figure S2). [score:1]
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[+] score: 5
Other miRNAs from this paper: hsa-mir-224, hsa-mir-141, hsa-mir-200c, hsa-mir-452, hsa-mir-877
All three microRNAs that are differentially expressed between the Xq tensor GSVD classes, and map to the same amplification, miR-888, miR-224, and miR-452, together with the gamma-aminobutyric acid (GABA) A receptor epsilon-encoding GABRE, which hosts mir-224 and mir-452 in its introns, are consistently overexpressed. [score:5]
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[+] score: 5
The expression of miR-888 targeting SPAG6 did not show a significant difference (Log [2] fold change = 0.11, p = 0.867). [score:5]
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[+] score: 3
For example, miR-888 is a miRNA secreted by prostate cells that promotes prostate cell growth and migration through the repression of the levels of protein produced by the tumor suppressor genes RBL1 and SMAD4 (6). [score:3]
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[+] score: 3
List of the most highly expressed human microRNAs in salivary microvesicles are: hsa-let-7b, hsa-let-7c*, hsa-miR-128, hsa-miR-150*, hsa-miR-17, hsa-miR-1908, hsa-miR-212, hsa-miR-27b*, hsa-miR-29b, hsa-miR-29c, hsa-miR-335, hsa-miR-379*, hsa-miR-433, hsa-miR-454, hsa-miR-483-3p, hsa-miR-584, hsa-miR-621, hsa-miR-652, hsa-miR-760 and hsa-miR-888* [9]. [score:3]
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[+] score: 3
Of the candidate miRNAs we examined, miR-23a, miR-129-2, miR-888, and miR-138-2 could suppress both mRNA and protein levels, with miR-23a being the most effective (Fig. 2B, C). [score:3]
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[+] score: 3
Similarly, of 46 suppressed miRNAs, we recognized 14 human-specific non-homologous miRNAs, including miR-1206, miR-548a-5p, miR-548f, miR-576-5p, miR-600, miR-639, miR-640, miR-641, miR-647, miR-662, miR-886-3p, miR-887, miR-628-3p, and miR-888. [score:3]
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[+] score: 3
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-17, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-32, hsa-mir-33a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-106a, mmu-let-7g, mmu-let-7i, mmu-mir-27b, mmu-mir-30a, mmu-mir-30b, mmu-mir-126a, mmu-mir-9-2, mmu-mir-135a-1, mmu-mir-137, mmu-mir-140, mmu-mir-150, mmu-mir-155, mmu-mir-24-1, mmu-mir-193a, mmu-mir-194-1, mmu-mir-204, mmu-mir-205, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-143, mmu-mir-30e, hsa-mir-34a, hsa-mir-204, hsa-mir-205, hsa-mir-222, mmu-let-7d, mmu-mir-106a, mmu-mir-106b, hsa-let-7g, hsa-let-7i, hsa-mir-27b, hsa-mir-30b, hsa-mir-135a-1, hsa-mir-135a-2, hsa-mir-137, hsa-mir-140, hsa-mir-143, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-126, hsa-mir-150, hsa-mir-193a, hsa-mir-194-1, mmu-mir-19b-2, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-mir-200a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-15a, mmu-mir-23a, mmu-mir-24-2, mmu-mir-29a, mmu-mir-31, mmu-mir-92a-2, mmu-mir-34a, rno-mir-322-1, mmu-mir-322, rno-let-7d, rno-mir-329, mmu-mir-329, rno-mir-140, rno-mir-350-1, mmu-mir-350, hsa-mir-200c, hsa-mir-155, mmu-mir-17, mmu-mir-25, mmu-mir-32, mmu-mir-200c, mmu-mir-33, mmu-mir-222, mmu-mir-135a-2, mmu-mir-19b-1, mmu-mir-92a-1, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-7b, hsa-mir-194-2, mmu-mir-194-2, hsa-mir-106b, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-30e, hsa-mir-375, mmu-mir-375, mmu-mir-133b, hsa-mir-133b, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-7b, rno-mir-9a-1, rno-mir-9a-3, rno-mir-9a-2, rno-mir-17-1, rno-mir-19b-1, rno-mir-19b-2, rno-mir-23a, rno-mir-24-1, rno-mir-24-2, rno-mir-25, rno-mir-27b, rno-mir-29a, rno-mir-30c-1, rno-mir-30e, rno-mir-30b, rno-mir-30d, rno-mir-30a, rno-mir-30c-2, rno-mir-31a, rno-mir-32, rno-mir-33, rno-mir-34a, rno-mir-92a-1, rno-mir-92a-2, rno-mir-106b, rno-mir-126a, rno-mir-135a, rno-mir-137, rno-mir-143, rno-mir-150, rno-mir-193a, rno-mir-194-1, rno-mir-194-2, rno-mir-200c, rno-mir-200a, rno-mir-204, rno-mir-205, rno-mir-222, hsa-mir-196b, mmu-mir-196b, rno-mir-196b-1, mmu-mir-410, hsa-mir-329-1, hsa-mir-329-2, mmu-mir-470, hsa-mir-410, hsa-mir-486-1, hsa-mir-499a, rno-mir-133b, mmu-mir-486a, hsa-mir-33b, rno-mir-499, mmu-mir-499, mmu-mir-467d, hsa-mir-891a, hsa-mir-892a, hsa-mir-890, hsa-mir-891b, hsa-mir-892b, rno-mir-17-2, rno-mir-375, rno-mir-410, mmu-mir-486b, rno-mir-31b, rno-mir-9b-3, rno-mir-9b-1, rno-mir-126b, rno-mir-9b-2, hsa-mir-499b, mmu-let-7j, mmu-mir-30f, mmu-let-7k, hsa-mir-486-2, mmu-mir-126b, rno-mir-155, rno-let-7g, rno-mir-15a, rno-mir-196b-2, rno-mir-322-2, rno-mir-350-2, rno-mir-486, mmu-mir-9b-2, mmu-mir-9b-1, mmu-mir-9b-3
Conversely, the 5 members of the miR-888 cluster (miR-890, miR-891a, miR-891b, miR-892a, and miR-892b) that have been reported as being highly expressed in the corpus and caudal regions of the human epididymis [12] were not detected in our analysis of the mouse epididymis or in previous work on the rat epididymis [7]. [score:3]
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[+] score: 3
Lewis H, Lance R, Troyer D, Beydoun H, Hadley M, Orians J, et al. miR-888 is an expressed prostatic secretions-derived microRNA that promotes prostate cell growth and migration. [score:3]
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[+] score: 1
Among them, miR-890, miR-888, miR-892a, and miR-892b are tightly clustered within a genomic region of 3 kb and are highly similar with each other, suggesting evolution of these members as a result of tandem duplication events. [score:1]
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[+] score: 1
Note that miR-628-5p and miR-888 are primate-specific miRNAs, which makes them very useful candidate miRNAs to distinguish not only pluripotent and differentiated cells, but also human and other non-primate species. [score:1]
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[+] score: 1
Hsa_circ_0001649 may play a role in tumorigenesis and metastasis of HCC through sponge-like activity toward several miRNAs, including miR-1283, miR-4310, miR-182-3p, miR-888-3p, miR-4502, miR-6811, miR-6511b-5p, and miR-1972 [127]. [score:1]
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[+] score: 1
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-21, hsa-mir-23a, hsa-mir-30a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-196a-1, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-196a-2, hsa-mir-210, hsa-mir-181a-1, hsa-mir-218-1, hsa-let-7g, hsa-let-7i, hsa-mir-23b, hsa-mir-30b, hsa-mir-128-1, hsa-mir-145, hsa-mir-191, hsa-mir-181b-2, hsa-mir-128-2, hsa-mir-30c-1, hsa-mir-99b, hsa-mir-296, hsa-mir-30e, hsa-mir-361, hsa-mir-337, hsa-mir-148b, hsa-mir-196b, hsa-mir-425, hsa-mir-20b, hsa-mir-486-1, hsa-mir-488, hsa-mir-181d, hsa-mir-498, hsa-mir-519c, hsa-mir-520a, hsa-mir-526b, hsa-mir-520d, hsa-mir-506, hsa-mir-92b, hsa-mir-608, hsa-mir-617, hsa-mir-625, hsa-mir-641, hsa-mir-1264, hsa-mir-1271, bta-let-7f-2, bta-mir-103-1, bta-mir-148a, bta-mir-21, bta-mir-30d, bta-mir-128-1, bta-mir-145, bta-mir-181a-2, bta-mir-30b, bta-mir-181b-2, bta-mir-20b, bta-mir-30e, bta-mir-92a-2, bta-let-7d, bta-mir-148b, bta-mir-181c, bta-mir-191, bta-mir-210, bta-mir-23a, bta-mir-361, bta-mir-425, bta-let-7g, bta-mir-30a, bta-let-7a-1, bta-let-7f-1, bta-mir-30c, bta-let-7i, bta-mir-23b, bta-let-7a-2, bta-let-7a-3, bta-let-7b, bta-let-7c, bta-let-7e, bta-mir-103-2, bta-mir-99b, hsa-mir-890, hsa-mir-889, hsa-mir-938, hsa-mir-1184-1, hsa-mir-1203, hsa-mir-1204, hsa-mir-1265, hsa-mir-103b-1, hsa-mir-103b-2, bta-mir-128-2, bta-mir-181d, bta-mir-196a-2, bta-mir-196a-1, bta-mir-196b, bta-mir-218-1, bta-mir-296, bta-mir-30f, bta-mir-486, bta-mir-488, bta-mir-92a-1, bta-mir-92b, bta-mir-1271, bta-mir-181a-1, bta-mir-181b-1, bta-mir-148c, hsa-mir-1184-2, hsa-mir-1184-3, hsa-mir-486-2, bta-mir-1264, bta-mir-148d
Among these, miR-938, miR-519c-3p, miR-1265, miR-498 and miR-488 were exclusively detected only in HE animals and 10 miRNAs including miR-608, miR-625*, miR-218-1*, miR-888*, miR-1184 and miR-1264 were detected only in SE and CE animal groups. [score:1]
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[+] score: 1
Nine miRNAs (miR-888-5p, miR-454-3p, miR-10a-5p, miR-181c-5p, miR-1909-3p, miR-20a-3p, miR-484, miR-501-5p, and miR-622) were detected in at least 50% of cases and not detected in the corresponding matched control. [score:1]
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[+] score: 1
In the human genome, FMR1 and AFF2 are located on the X chromosome, adjacent to two recognised miRNA clusters (miR-888:892 and miR-506:514). [score:1]
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