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15 publications mentioning hsa-mir-1225

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-1225. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 381
In addition, considering that overexpression of miR-1225 decreased both mRNA and protein level of β-catenin (data not shown) together with the finding that miR-1225-5p could decrease the expression of IRS1, one may speculate that miR-1225-5p was able to transcriptionally downregulate β-catenin through decreasing the expression of IRS1. [score:10]
We found that miR-1225-5p could directly bind the 3′-UTR of IRS1 and over -expression of miR-1225-5p downregulated IRS1 expression in both mRNA and protein level. [score:9]
The quantitative PCR results confirmed the expression of two most upregulated (hsa-miR-361-5p and hsa-miR-214) and downregulated (hsa-miR-1225-5p and hsa-miR-148a) miRNAs in the same 35 GC pairs (Figure 1B). [score:9]
Given that IRS1 may be a direct target of miR-1225-5p and possibly involve in gastric tumorigenesis, we first asked whether downregulation of IRS1 could suppress GC cell growth and reduce their invasive potential. [score:9]
These data points toward an important role of miR-1225-5p, similar to tumor suppressor, in GC cell growth, invasion and metastasis, MiRNAs may exert diverse biological functions by regulating the expression of downstream target genes in different tissues or cancers. [score:8]
B. Validation of two most differentially upregulated (miR-214 and miR-361-5p) and downregulated (miR-148a and miR-1225-5p) miRNAs in tumor and corresponding nontumorous pairs used for microarray analysis. [score:7]
Collectively, these data indicate that downregulation of miR-1225-5p in GC is associated with activation of β-catenin through upregulation of IRS1. [score:7]
Western blot shows MGC803-1225+ cell transfected with IRS1 -expressing plasmid blocked miR-1225-5p -induced suppression of IRS1 protein expression. [score:7]
Re -expression of miR-1225-5p effectively slowed tumor cell growth, and inhibited colony formation as well as suppressed GC xenograft tumor growth in nude mice. [score:7]
To understand the mechanisms underlying miR-1225-5p induced inhibition of GC growth and metastasis, the bioinformatics algorithms of TargetScan, pictar and miRanda were employed to predict potential targets by compiling all the predicted genes for functional clustering analysis classified by Gene Ontology and KeGG pathway database. [score:7]
Results obtained from these studies clearly indicate that downregulation of miR-1225-5p in GC is associated with upregulation of IRS1 and activation of β-catenin signaling pathway, thus contributing to the tumor growth and metastasis. [score:7]
Two most upregulated (hsa-miR-361-5p and hsa-miR-214) and two most downregulated (hsa-miR-1225-5p and hsa-miR-148a) miRNAs were further validated using qRT-PCR in GC tissue pairs. [score:7]
To further ascertain the downregulation of miR-1225-5p in GC, expression of miR-1225-5p in six GC cell lines and 60 pairs of primary GC was examined by quantitative PCR. [score:6]
To address the issue of whether miR-1225-5p has an effect on the development and progression of GC, we re-expressed miR-1225-5p in GC cell lines MGC803 and SGC7901, both of which have a low basal level of miR-1225-5p expression. [score:6]
These results implicate that miR-1225-5p might directly target IRS1 and expression of IRS1 is correlated with gastric tumorigenesis. [score:6]
The result showed that the expression of IRS1 mRNA and protein was downregulated in miR-1225-5p treated cells (Figure 4C, 4D). [score:6]
Furthermore, enhanced expression of IRS1 promoted GC cell growth and invasion, and more importantly, blocked miR-1225-5p -induced suppression of cell proliferation and invasion. [score:5]
Taken together, these results suggest that the tumor-suppressive effect of miR-1225-5p is mediated, at least in part, through inhibition of IRS1. [score:5]
The median value of all 130 GC samples was set as the cut-off point to separate tumors with low-level expression of miR-1225-5p from those with high-level expression of miR-1225-5p. [score:5]
These results suggest that downregulation of miR-1225-5p may promote the development and progression of GC. [score:5]
D. shows that miR-1225-5p inhibited the protein expression of IRS1 in MGC803-1225+ (left panel) and SGC7901-1225+ (right panel) cells. [score:5]
Stable miR-1225-5p overexpressing clones (MGC803-1225+ or SGC7901-1225+) and empty vector -transfected cells (MGC803-vector or SGC7901-vector) with a low basal level of miR-1225-5p expression were selected for further study. [score:5]
In this study, we found that expression of β-catenin in miR-1225-5p overexpressed GC cells was significantly reduced. [score:5]
In our study, prediction of the candidate target genes for miR-1225-5p was performed by bioinformatics tools (Targetscan, PicTar and MiRanda). [score:5]
As shown in Figure 2B, cell proliferation was suppressed significantly by ectopic expression of miR-1225-5p in both MGC803 and SGC7901 cells. [score:5]
To address the clinical significance of the downregulation of miR-1225-5p in GC, the correlation of miR-1225-5p downregulation with clinicopathologic features of 130 patients was investigated. [score:5]
Among these, miR-1225-5p was demonstrated to function as a tumor suppressor since loss of miR-1225-5p expression was frequently observed in GC and strongly associated with poor patient outcome. [score:5]
Collectively, these data indicate that miR-1225-5p acts as a novel tumor suppressor that inhibits gastric tumor growth. [score:5]
Downregulation of miR-1225-5p in GC tumors, which is strongly correlated with tumor progression and clinical prognosis, merits further development as a diagnostic and prognostic biomarker. [score:5]
Colony-forming assay further confirmed the inhibitory effect of miR-1225-5p on the growth of these miR-1225-5p overexpressing cells (Figure 2C). [score:4]
Downregulation of miR-1225-5p in gastric carcinoma (GC), which is associated with poor prognosis. [score:4]
C. Quantitative PCR result shows that IRS1 was downregulated by miR-1225-5p in MGC803-1225+ (left panel) and SGC7901-1225+ (right panel) cells (**p<0.01). [score:4]
C. Downregulation of miR-1225-5p was observed in six GC cell lines. [score:4]
Consistent with the results obtained from the, miR-1225-5p was markedly downregulated in both the GC cell lines and primary GC tumors (Figures 1C and 1D). [score:4]
E. Downregulation of miR-1225-5p was significantly associated with poorer overall survival. [score:4]
Correlation of miR-1225-5p downregulation with clinicopathological features of 130 GC patients. [score:4]
IRS1 is a direct target of miR-1225-5p. [score:4]
F. Migration and invasion assays show that IRS1 restoration abolished miR-1225-5p -induced suppression of invasion and metastasis in MGC803-1225+ cell after transfected with IRS1 -expressing plasmid. [score:4]
miR-1225-5p is downregulated in GC and correlates with poor prognosis. [score:4]
We found that miR-1225-5p was downregulated in primary GC tumors with a highest absolute fold change. [score:4]
E. Cell growth curves by CCK-8 assay show that IRS1 restoration abrogated miR-1225-5p -induced suppression of proliferation in MGC803-1225+ cell after transfected with IRS1 -expressing plasmid. [score:4]
In addition, miR-1225-5p may be a potential target in cancer therapy since it regulates IRS1 and consequent β-catenin pathway, a frequent and crucial signaling event associated with malignant transformation. [score:4]
showed that the expression of both cytoplasmic and nuclear β-catenin in MGC803-1225+ and SGC7901-1225+ cells was significantly reduced as compared with empty vector -transfected cells (Figure 6A), indicating that there was an association between the expression levels of miR-1225-5p and activation of β-catenin in GC cells. [score:4]
Mechanistically, insulin receptor substrate 1 (IRS1) was identified as a direct functional target of miR-1225-5p and consequently augmented β-catenin activity ultimately leading to the malignant phenotypes. [score:4]
Taken together, these data demonstrated that IRS1 functions as a downstream effector of miR-1225-5p and positively regulates β-catenin activity and downstream targets. [score:4]
Representative bioluminescence images of whole mouse and the livers of the BALB/c nude mice 42 days after tail vein injection of 2 × 10 [6] MGC803-1225+ or MGC803-vector cells, showing less metastasis when miR-1225-5p was expressed. [score:3]
The prognostic significance of miR-1225-5p in GC was determined by Kaplan-Meier analysis demonstrating that low miR-1225-5p expression was associated with poorer overall survival in the GC cohort (Figure 1E). [score:3]
A. Relative expression of miR-1225-5p was detected by quantitative PCR in stably transfected MGC803 (MGC803-1225+) and SGC7901 (SGC7901-1225+) cells relative to empty vectors (MGC803-vector or SGC7901-vector). [score:3]
C. Colony formation in soft agar was significantly suppressed by miR-1225-5p. [score:3]
Enhanced expression of IRS1 reverses the effect of miR-1225-5p. [score:3]
The χ [2] test or Fisher's exact test was used to analyze the association of miR-1225-5p expression and clinical-pathological parameters. [score:3]
The expression of mature miR-1225-5p in the stably transfected cells was confirmed by quantitative PCR (Figure 2A). [score:3]
miR-1225-5p suppresses GC invasion and metastasis. [score:3]
In the present study, we demonstrated that miR-1225-5p was significantly downregulated in six GC cell lines and GC tissue samples as compared to the normal gastric tissues. [score:3]
A. The predicted binding sequence of human hsa-miR-1225-5p and its binding site in the 3′-untranslated region (UTR) of IRS1 (wt) was presented for alignment. [score:3]
Our next step was to investigate if miR-1225-5p inhibits β-catenin through suppression of IRS1. [score:3]
For in vivo tumor growth study, 2 × 10 [6] miR-1225-5p overexpressing MGC803-1225+ cells and the control MGC803-vector cells were inoculated subcutaneously on the left and right flank region, respectively, of 4~6-week-old BALB/c nude mice (eight mice per group). [score:3]
D. miR-1225-5p was significantly downregulated in 60 primary GC compared with their corresponding nontumorous tissues. [score:3]
Moreover, we showed that low miR-1225-5p expression in GC tumors was associated with poorer overall survival. [score:3]
miR-1225-5p suppresses GC cell growth. [score:3]
Figure 4 A. The predicted binding sequence of human hsa-miR-1225-5p and its binding site in the 3′-untranslated region (UTR) of IRS1 (wt) was presented for alignment. [score:3]
Figure 3 A. miR-1225-5p inhibited migration of MGC803-1225+ (upper right panel) and SGC7901-1225+ (lower right panel) cells (p<0.001). [score:3]
A. miR-1225-5p inhibited migration of MGC803-1225+ (upper right panel) and SGC7901-1225+ (lower right panel) cells (p<0.001). [score:3]
D. Tumor growth curves show that miR-1225-5p inhibited xenograft tumor growth in nude mice (upper left panel). [score:3]
B. miR-1225-5p inhibited invasion of MGC803-1225+ (upper right panel) and SGC7901-1225+ (lower right panel) cells (p<0.001). [score:3]
The expression of miR-1225-5p in the stable cell lines was confirmed by quantitative PCR. [score:3]
A robust association between low miR-1225-5p expression in tumors with advanced clinical stage, depth of local invasion, lymph node metastasis, and distant metastasis was confirmed in 130 patients with GC. [score:3]
However, enhanced expression of miR-1225-5p did not produce any change in the basal rate of cells undergoing apoptosis (Supplementary Figure S1). [score:3]
After 18~24 h incubation, 1 mg pmirGLO report vector carrying wild type 3′-UTR or mutated 3′-UTR of miR-1225-5p targets was cotransfected with 100 pmol negative control or miR-1225-5p mimic into the GC cells using X-tremeGENE reagent. [score:3]
The average mRNA expression levels in cancerous tissues were increased by 2.81- and 1.92-fold (p < 0.01 for both) for hsa-miR-361-5p and hsa-miR-214, but decreased by 4.76- and 6.25-fold (p < 0.01 for both) for hsa-miR-148a and hsa-miR-1225-5p relative to those in the adjacent normal tissues. [score:3]
D. Representative bioluminescence images of whole mouse and mouse lung lobes showing that expression of miR-1225-5p decreased the extent of metastasis to lung when imaged at 42 days after the tail vein injection. [score:3]
In summary, this is the first study to explore the role of miR-1225-5p in cancer and demonstrate that miR-1225-5p is likely to function as a tumor suppressor specifically in GC. [score:3]
In addition, re -expression of miR-1225-5p decreased tumor cell motility and invasion. [score:3]
Figure 2 A. Relative expression of miR-1225-5p was detected by quantitative PCR in stably transfected MGC803 (MGC803-1225+) and SGC7901 (SGC7901-1225+) cells relative to empty vectors (MGC803-vector or SGC7901-vector). [score:3]
Since the expression of hsa-miR-1225-5p had the largest absolute fold change from the miRNAs profiling analysis, it was chosen for all the subsequent studies. [score:3]
Construction of the miR-1225-5p expression plasmid and packaging lentivirus were provided by Genechem Biotechnology (Shanghai, China). [score:3]
lentivirus control, MGC803-vector cell; miR-1225-5p, MGC803-1225+ cell; vector, pcDNA3.1/myc-His(−)A empty plasmid; IRS1, IRS1 -expressing plasmid; +, plasmid added; —, no plasmid added. [score:3]
Altogether, we assume that miR-1225-5p function as a tumor suppressor in GC and may be exploited as a prognostic biomarker in GC. [score:3]
Correlation analysis showed that low-level expression of miR-1225-5p in GC was significantly associated with a more aggressive tumor phenotypes including local invasion, lymph node metastasis, advanced clinical stage and distant metastasis (Table 2). [score:3]
The impact of miR-1225-5p on metastatic potential in vivo was assessed by molecularly engineering the MGC803-1225+ cells to express the luciferase protein and then injecting 2 × 10 [6] cells into the tail vain of BALB/c nude mice. [score:3]
C. miR-1225-5p suppressed GC cell metastasis in vivo. [score:3]
These findings suggest that miR-1225-5p plays a crucial role in initiation and development of GC. [score:2]
Overexpression of miR-1225-5p in MGC803-1225+ and SGC7901-1225+ cells substantially impaired the cell migratory ability as compared with the empty vector -transfected cells (Figure 3A). [score:2]
To investigate the relationship of IRS1 and miR-1225-5p in regulation of cell proliferation, migration and invasion, IRS1 -expressing plasmid was introduced into MGC803-1225+ cells (Figure 5D) for assessment of phenotypic changes. [score:2]
Consistent with the results obtained from the in vitro growth assays, miR-1225-5p significantly inhibited the xenograft tumor growth in nude mice (Figure 2D). [score:2]
B. miR-1225-5p inhibited the cell growth rate in MGC803-1225+ (upper panel) and SGC7901-1225+ (lower panel) cells detected by CCK-8 assay. [score:2]
These results suggest a strong negative regulation between miR-1225-5p and IRS1 in GC. [score:2]
Knockdown of miR-1225-5p promoted gastric cancer cell proliferation, invasion and xenograft tumor growth and metastasis. [score:2]
Similarly, miR-1225-5p significantly decreased GC cell invasion through the Matrigel-coated transwell inserts (Figure 3B). [score:1]
Interestingly, luciferase activity was significantly reduced in those cells cotransfected with IRS1 3′-UTR sequence and miR-1225-5p but not in the cells with other three genes 3′-UTR sequence and miR-1225-5p (Supplementary Figure S2). [score:1]
A. shows that miR-1225-5p decreased the protein levels of nuclear and cytoplasmic β-catenin in MGC803-1225+ (left panel) and SGC7901-1225+ (right panel) cells. [score:1]
More importantly, an interaction between miR-1225-5p and IRS1 3′-UTR was specific as introduction of mutated IRS1 3′-UTR together with miR-1225-5p mimic into MGC803 cells did not alter the luciferase activity (Figure 4A, 4B). [score:1]
Mut-1 and mut-2 were two mutant sequences of 3′-UTR of IRS1 with the binding sites of miR-1225-5p. [score:1]
Consistently, a metastasis experimental animal mo del also confirmed that miR-1225-5p significantly reduced the colonization of metastatic tumors in the liver and lungs. [score:1]
MiR-1225-5p is a newly identified and rarely reported miRNA. [score:1]
These results clearly indicate that miR-1225-5p functions to limit migration, invasion and metastasis as well. [score:1]
The stable miR-1225-5p overexpressing (MGC803-1225+ and SGC7901-1225+) or empty vector -transfected cells were seeded at a density of 5× 10 [3] cells per well in 96-well plates and incubated at 37°C, 5% CO [2] for 24, 48, 72 or 96 h. 10 mL of CCK-8 solution was added into each well and incubated at 37°C for 4 h. The absorbance at 450 nm was measured using a microplate reader. [score:1]
The plasmids (wt or mut) were co -transfected with miR-1225-5p mimic or scramble mimic. [score:1]
Figure 6 A. shows that miR-1225-5p decreased the protein levels of nuclear and cytoplasmic β-catenin in MGC803-1225+ (left panel) and SGC7901-1225+ (right panel) cells. [score:1]
PmirGLO vector was co -transfected with miR-1225-5p mimic and scramble mimic as positive control. [score:1]
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2
[+] score: 26
Mir-1225 targets the polycystic kidney disease gene, PKD1, which is frequently mutated in autosomal dominant polycystic kidney disease; thus, miR1225 may affect the progression of this disease [31]. [score:9]
Two of them (miR-1225-5p and miR-320c) and miR-21 with the highest signal intensity among the MA-specific miRNAs were validated as being differentially expressed in 18 PLF samples, using qPCR (Table 3). [score:3]
Mir-1225-5p showed higher expression in T4 than in T1–T3 stage CG patients, confirming the results obtained by microarray, whereas there was no difference in miR-320 levels between patient groups. [score:3]
Using a step-wise approach, we selected five exosomal miRNAs (miR-320c, miR-1202, miR-1225-5p, miR-1207-5p, and miR-7270) and validated miR-320 and miR1225-5p expression in the PLF of 18 CG patients by qRT-PCR. [score:3]
Eighteen PLF samples were divided into two groups according to the metastatic stage, T4 (perforated serosa, n = 9) and T1–T3 (subserosa or less, n = 9), and the expression of miR-21, miR-320c, and miR-1225-5p was analysed by qRT-PCR. [score:3]
MiR-21 and miR-1225-5p expression was significantly higher in patients with T4-stage cancer than that in T1–T3-stage patients (P = 0.015). [score:3]
MiR-21 and miR-1225-5p may prepare a premetastatic niche in the peritoneum for the dissemination and settlement of metastasising cancer cells and thus may indicate the predisposition for the peritoneal recurrence after curative GC resection. [score:1]
However, the relationship between miR-1225 and cancer remains unclear. [score:1]
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3
[+] score: 23
miR-211-5p, miR-5095, and miR-1225-3p all had positive correlations and were similarly upregulated in the longer-lived subgroup but downregulated in the shorter lived subgroup. [score:7]
One target, PARP1 mRNA [Poly(ADP-ribose) Polymerase 1], was found in the target lists of both miR-374a and miR-1225. [score:5]
We found that miR-1225 had the most aging -associated targets at 25%, in which 3 out of 12 validated targets were also listed in the GenAge database [25]. [score:5]
Notably, PARP1 mRNA, found in target lists of both miR-374a and miR-1225, encodes PARP1, a protein known for its role in repairing single-strand breaks during DNA replication [29, 30]. [score:3]
Note that PARP1 (Poly(ADP-ribose) Polymerase 1) mRNA is a validated target of both miR-374a and miR-1225. [score:3]
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4
[+] score: 22
Interestingly, we found that 116 genes of our signature are predicted targets of deregulated microRNAs; in particular, the down-regulated gene SYK is target of all up-regulated microRNAs, while LGALS1 is a putative target of miR-1207-5p, miR-1225-5p. [score:14]
Interestingly, the showed that SYK is a putative target of all up-regulated microRNAs, while LGALS1 is a predicted target only of miR1207-5p and miR1225-5p. [score:8]
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5
[+] score: 17
revealed that the expression of human miR-184, miR-1225-5p and miR-30c-2-3p was up-regulated in human spermatogonia compared to pachytene spermatocytes, whereas miR-126-3p, let-7a-5p and miR-125b-5p were down-regulated in human spermatogonia compared with pachytene spermatocytes (Fig. 6A), which was completely consistent with our miRNA microarray data. [score:7]
Specifically, E2F transcription factor 1 (E2F1) was a potential binding target for human miR-184 (Fig. 7A), while Ets variant 1 (ETV1) was a target of miR-1225-5p (Fig. 7B). [score:5]
Using different miRNA software programs, including TargetScan, miRbase, and miRDB 5, we predicted the targeting genes of human miR-1225-5p, miR-184, miR-30c-2-3p, let-7a-5p, miR-125b-5p and miR-126-3p. [score:5]
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6
[+] score: 11
The expression levels of miR-1225-5p, miR-1909-5p, miR-512-5p, miR-3927, miR-1203, miR-2110, miR-501-5p, miR-648, miR-4729, miR-4475, miR-1914-3p and miR-5002-5p were downregulated in the children with CPHD. [score:6]
However, the expression levels of miR-1225-5p, miR-1909-5p, miR-512-5p, miR-3927, miR-1203, miR-2110, miR-501-5p, miR-648, miR-4729, miR-4475, miR-1914-3p and miR-5002-5p were downregulated (Fig. 2B) (P<0.05) in the children with CPHD compared with the normal controls. [score:5]
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7
[+] score: 7
In basal conditions (day 0), up-regulated miRNAs were: miR-1225-3p, miR-1305, miR-1238, miR-425, miR-191* and miR-34a, while miR-378 was the only down-regulated miR. [score:7]
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8
[+] score: 5
However, although TLR2 is targeted by several human miRNAs including miR-105, miR-19, miR-1225-5p, miR-143 and miR-154 in a variety of cell types [38– 42], no viral miRNA has been shown to target TLR2—until now. [score:5]
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9
[+] score: 4
Nineteen of the downregulated miRNAs in chronic patients were found to be associated with carcinogenesis in various organs and tissues, such as miR-1207 [40], miR-3162-5p [41, 42], miR-3196 [43, 44], miR-371b-5p [45], miR-574-5p [46, 47], miR-1225-5p [48], miR-4485 [49], miR-572 [50], miR-4299 [51], miR-3679-5p [52], miR-3940-5p [53], miR-638 [54, 55], miR-1202 [56], miR-5787 [57], miR-1973 [58], miR-4532 [59], miR-1275 [60], miR-4728-5p [61], and miR-1915-3p [62]. [score:4]
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10
[+] score: 4
Among the top ten fold changed miRNAs (Supplementary Table 1), half of them (hsa-miR-371b-5p, hsa-miR-663a, hsa-miR-1225-5p, hsa-miR-1202, and hsa-miR-572) were closely linked to the occurrence and development of tumors and might play vital roles as oncogenes or tumor suppressor genes [28– 31]. [score:4]
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11
[+] score: 3
Our results reported 42 differentially expressed miRNAs in PBLs cultured for 24 h in MMG with respect to 1 g, of which 14 (miR-34a-5p, miR-34b-5p, miR-663a, miR-135a-3p, miR-1225-5p, miR-940, miR-221-5p, miR-29b-1-5p, miR-10a-5p, let-7i-3p, miR-200a-3p, miR-7-5p, miR-7-1-3p, and miR-505-5p) were found altered also by γ-irradiation, as assessed in our previous study [47]. [score:3]
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12
[+] score: 2
Simultaneously some non-canonical miRNAs (e. g. originated from simtrons mir-1225 and mir-1228) are distant from the terminal loop. [score:1]
Mammalian mir-1225 and mir-1228, initially predicted as mirtrons, are actually splicing-independent [35]. [score:1]
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13
[+] score: 2
Unfortunately, we found miR-1225 was hardly detected in northern blot analysis despite of high level of signal intensity in microarray analysis. [score:1]
Interestingly, three mirtrons (miR-877, miR-1224, miR-1225) were included. [score:1]
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14
[+] score: 1
Indeed, some miRNAs that have been previously linked to carcinogenesis of different organs and tissues, such as miR-2861 [47, 48], miR-4530 [49], miR-638 [50], miR-371b-5p [51], miR-1225-5p [52, 53], miR-296-5p [54, 55], miR-4787-5p [56], miR-4281 [57], miR-4455 [58], miR-197-3p [59], miR-369-5p [60, 61] and miR-505-3p [62] which were found to be altered in brucellosis in our analysis. [score:1]
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15
[+] score: 1
These two FSHD1 fetal muscle biopsies share 11 miRNAs with similar modulations (Fig. 4), miR-1225–3p, miR-19b-1*, miR-208b, miR-22, miR-372, miR-383, miR-767–3p, miR-802, miR-872, miR-875–5p, and miR-892b. [score:1]
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