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15 publications mentioning hsa-mir-1304

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-1304. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 24
Five representative differentially expressed miRNAs (hsa-miR-181a, hsa-miR-769-5p, hsa-miR-361-5p, hsa-miR-1304, and hsa-miR-608) were selected to undergo RT-qPCR validation based on highest fold-change as well as putative targets as identified by the TargetScan web tool (Fig. 5a). [score:7]
However, RT-qPCR performed on NP-69 normal cells indicated opposing results in relation to miR-181a, miR-769-5p and miR-1304 expression, with these miRNAs being up-regulated. [score:6]
While hsa-miR-608 was significantly up-regulated in NP-69 cells following transfection with si Bcl-xL, it was found that opposing results were observed in NP-69 cells in regards to the expression of miR-181a, miR-769-5p and miR-1304, in comparison to A549 and SK-LU1 cells (Fig. 5a). [score:6]
Bioinformatic analyses predicted that the five significantly dysregulated miRNAs (hsa-miR-181a, hsa-miR-769-5p, hsa-miR-361-5p, hsa-miR-1304, and hsa-miR-608) were linked to various apoptotic signaling pathways, including the PI3K/AKT, WNT, TGF-β, MAPK/ERK and the intrinsic pathway, and all were implicated as those directly affected by Bcl-xL levels. [score:3]
All experiments were carried out with three independent biological replicates and presented as mean ± S. D. (A) RT-qPCR of the five miRNAs (hsa-miR-181a, hsa-miR-769-5p, hsa-miR-361-5p, hsa-miR-1304, and hsa-miR-608) validated against microarray results, and presented as normalized fold-change values. [score:1]
0081735.g005 Figure 5(A) RT-qPCR of the five miRNAs (hsa-miR-181a, hsa-miR-769-5p, hsa-miR-361-5p, hsa-miR-1304, and hsa-miR-608) validated against microarray results, and presented as normalized fold-change values. [score:1]
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2
[+] score: 21
Among the 63 upregulated and 49 downregulated miRNAs in both the CP and CLP plasma samples, six miRNAs, namely miR-340–5p, miR-877–5p, miR-3648, miR-1260a, miR-494–3p, and miR-1304–3p, were selected for expression validation (Table 3). [score:9]
Relative expression level (2 [−ΔΔCt]) of miR-340-5p, miR-877-5p, miR-3648, miR-1260a, miR-494-3p, and miR-1304-3p expression in the plasma of cleft palate patients (n =16), cleft lip with cleft palate patients (n = 33) and controls (n = 8) (Mann-Whitney U test). [score:5]
In contrast, three miRNAs, miR-1260a, miR-494–3p and miR-1304–3p, were significantly downregulated in both the CP and CLP plasma samples (Figure 2). [score:4]
Six miRNAs, namely miR-340–5p, miR-877–5p, miR-3648, miR-1260a, miR-494–3p, and miR-1304–3p, were found to be differentially expressed in both the NSCP and NSCLP plasma samples. [score:3]
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3
[+] score: 20
In particular, isomiRs from the miR-1304-3p precursor arm, a locus previously associated with regulating enamel formation in Neanderthals [18], were significantly up-regulated in the YRI population (in both males and females) whereas isomiRs from the miR-143-3p precursor arm were significantly up-regulated in the CEU population (but only in females). [score:8]
There are 2,355 predicted targets for miR-1304-3p isomiRs and 2,358 predicted targets for miR-143-3p isomiRs. [score:5]
Several isomiRs stand out in these comparisons with the ones from the right arm of miR-1304 and the right arm of miR-143 being the most notable. [score:1]
’ Analogously, for miR-1304-3p we find a strong enrichment for genes that participate in DNA replication, ribonucleoprotein complex biogenesis, mRNA metabolism and catabolism, RNA splicing, response to DNA damage etc. [score:1]
GO term analysis for miR-1304-3p and miR-143-3p. [score:1]
We took a closer look at the two miRNA precursor arms, miR-1304-3p (YRI vs. [score:1]
With that in mind one might argue that the findings regarding the isomiRs from the miR-1304-3p (YRI-vs. [score:1]
Indeed, the isomiRs from the miR-143-3p (CEU) and miR-1304-3p (YRI) arms are the only miRNAs distinguishing the older CEU and YRI samples from the remaining three younger FIN, GBR and TSI samples. [score:1]
B: This panel shows a boxplot for the miR-1304-3p arm within each of the five population groups (both genders): miR-1304-3p is more abundant in the YRI population. [score:1]
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4
[+] score: 15
The number of targets that passed quality control filters for the remaining HPD-miRNA were hsa-mir-202 (1145 targets), hsa-mir-1304 (710 targets), hsa-mir-1269a (488 targets), hsa-mir-4482-1 (144 targets), hsa-mir-449c (69 targets), and hsa-mir-4707 (1 target). [score:15]
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5
[+] score: 14
Among the differentially expressed miRNAs, up-regulated miRNAs including miR-34b-5p, miR-578, miR-1304, and miR-324-5p and down-regulated miRNAs including miR-7-5p, and miR-34b-3p were analyzed using primers for mature mRNAs (B). [score:8]
The differential expression of miRNAs from array experiments was confirmed by further analysis of selected miRNAs, including miR-7-5p, miR-34b-3p, miR-34b-5p, miR-578, miR-1304, and miR-324-5p, using qRT-PCR. [score:3]
Expression of miR-578, miR-1304, and miR-324-5p showed 1.5, 2.4, and 3.7 fold increase, respectively, but did not reach statistical significance. [score:3]
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6
[+] score: 7
Other miRNAs from this paper: hsa-mir-223
We found that a number of our candidate motifs fall within the sequence of a number of HERV sequences, and the miRNA sequence miR-1304 and also fall within the 3’ UTRs of a couple of genes which are regulated by this latter miRNA. [score:2]
Overall, ten significant whole genome motifs from human were found in the 22 bp seed sequence of miR-1304 (CACATCTCACTGTAGCCTC[A/G]AA), which are listed in Table 6. MiR-1304 has also been shown to regulate two genes, ENAM and AMTN, which code for the enamelin and amelotin proteins, which take part in odontogenesis [35]. [score:2]
For example, miR-1304 differs in only one single bp between human and Neanderthal, and is responsible for dental and other craniofacial differences [34]. [score:1]
Examination of motif content similarity in miR-1304. [score:1]
The sequence for has-mir-1304 was retrieved from the miRBase database (SCR_003152) [20] at http://www. [score:1]
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7
[+] score: 6
In addition, a Neanderthal variant in the post-transcriptional repressor miR-1304 leading to a reduced expression of enamelin and amelotin genes could explain the variation in enamel thickness between Neanderthals and modern humans [26]. [score:3]
In support, the post-transcriptional repressor miR-1304 ancestral allele present in Neanderthals and today restricted to Asia (6% frequency in South Asia), which is responsible for the lower expression of the dental proteins enamelin and amelotin, may also shape the dentition or contribute to a higher risk of amelogenesis imperfecta in Asian populations [26]. [score:3]
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8
[+] score: 6
HO-1 over -expression has been reported to be involved in tumor growth and malignant progression [31– 35], previous study from our laboratory has demonstrated that HO-1 is down-regulated by miR-1304 in lung cancer cell lines [37]. [score:6]
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9
[+] score: 4
Of the 34 upregulated miRNAs examined, we identified 11 human-specific non-homologous miRNAs, including miR-1261, miR-1268, miR-1280, miR-1304, miR-1308, miR-1908, miR-198, miR-513a-5p, miR-513b, miR-548h, and miR-580 (Supplementary Table 1A). [score:4]
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10
[+] score: 4
The same region also has three miRNA (miR-7156-3p, miR-1184 and miR-1304-3p) target sites, with a potential for cross-talk between these events. [score:3]
The same site harbors binding sites for miR-7156-3p, miR-1184 and miR1304-3p and a SNP (rs921864) with pair-wise F [ST] (YRI-CHB) 0.66, H < −20, iHS 2.46 in YRI and DAF > 0.5. [score:1]
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11
[+] score: 1
This finding implied a potential relevance of miR-1304 to psychiatric disorders. [score:1]
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12
[+] score: 1
Stringent editing criteria (recurrence in > 50 samples) identified 18 editing sites in 10 miRNAs (mir-24-2, mir-27a, mir-27b, mir-605, mir-641, mir-1254, mir-1285-1, mir-1304, mir-3126, and mir-3138; Table S5) and 2 snoRNAs (U88 and SNORD17). [score:1]
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13
[+] score: 1
Only two of the 31 CA-derived miRNAs were also found in the 18 AA-derived miRNAs, namely miR-181a and miR-1304. [score:1]
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14
[+] score: 1
The microRNAs filtered in intact comparison but not filtered in HFD comparison and no-T2D comparison, including miR-143-3p, miR-99a-5p, miR-138-5p, miR-1304-3p, and miR-33b-5p, might involve the progress of T2D fed with normal diets only. [score:1]
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15
[+] score: 1
Other miRNAs from this paper: hsa-mir-411
Interestingly, two positions residing in mir-1304 were consistently edited in all tissues (Supplementary Figure 13). [score:1]
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