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3 publications mentioning hsa-mir-1976

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-1976. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 28
The expression of both RSK and RICTOR appears compatible with the identified PPL: (1) RSK (E-MTAB-62 experiment, filtered by ALL) shows an upper regulation in ALL (p = 0.002), and it may confirm the attempt of the pathway to protect its correct behavior maximizing the production of protective miR-1976 by over -expressing its host gene; (2) RICTOR (E-MTAB-37 experiment, filtered by ALL) appears globally down (p = 9.07e - 4), accordingly with the observed miR-196b up-regulation. [score:9]
As shown in Figure  3, the PPL is composed of a pathway host-gene (RSK) expressing a protective intragenic miRNA (miR-1976) which acts against the expression of the MLL transcription factor. [score:5]
The common assumption is that miRNAs discovered in a pathological context have a dysregulatory role; in this case the PPL suggests instead that miR-1976 [25] may have a protective role, and its slight over expression may indicate the mTOR pathway attempt to protect itself. [score:4]
Similarly, the same work shows that the level of miR-196b is decreased up to 14-fold in the absence of MLL, thus confirming the down-regulatory role of miR-1976 on MLL. [score:4]
In this case, we identified three additional low-score miR-1976 targets in the mTOR pathway, which are PAG Transcription Factors involved in PPLs. [score:3]
The most common pathological rearrangements of MLL (t(4;11), t(11;19), t(9;11) and t(1;11)) may mislead the proper miR-1976 regulatory function because the MLL translocation may imply changes in its miRNAs binding sites. [score:2]
This result seems to strongly confirm the central role of MLL, the HOXA cluster (HOXA9), and both miR-196b and miR-1976 in Acute Lymphoblastic Leukemia (ALL), as presented by Schotte et al. [25, 45]. [score:1]
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2
[+] score: 7
In fact miR-1976 is a potential tumour suppressor in lung cancer, as described in relation with the oncogene PLCE1 49. [score:3]
Moreover, in terms of the 13 miRNAs involved in these lung exclusive interactions, 16 of the 40 associations involve miR-miR-1976, which regulates 16 genes involved in cell cycle, apoptosis and the DDR. [score:2]
When comparing miRNA-mRNA interactions among tumour types, we observed that tumours of the same origin exhibited interactions not identified in the remaining tumours (Supplementary Figure 3), in particular lung cancers (LUAD and LUSC), and that these were mostly mediated by two types of miRNAs, miR-1976 and let-7b-5p. [score:1]
For instance miR-miR-1976 and miR-let-7b-5p miRNAs had already been associated to prognosis in lung cancer 49 69, and in other tumours like breast 70, prostate 71, and gastric 72. [score:1]
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3
[+] score: 3
Other miRNAs from this paper: mmu-mir-125a, hsa-mir-125a, mmu-mir-342, hsa-mir-342, hsa-mir-4638
Based on context scores and context score percentile as well as the outcome from multiple program prediction analysis, certain miRNAs, such as hsa-miR-4638-5p, hsa-miR-342-5p, hsa-miR-1976, hsa-miR-125a-3p and others were predicted to efficiently target the SLC44A4 3’-UTR. [score:3]
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