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32 publications mentioning ssc-mir-29a

Open access articles that are associated with the species Sus scrofa and mention the gene name mir-29a. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 67
This is consistent with up-regulation of ssc-miR-29a at 14d pi, whereas up-regulation of ssc-miR-182 – another PTEN -targeting miRNA – may be a contributing factor to PTEN down-regulation at 24 h pi given that ssc-miR-29a is itself down-regulated at this time point. [score:15]
In a previous study inhibition of miR-29a(-3p) in human hepatoma cell lines was shown to lead to up-regulation of PTEN at mRNA and protein levels, whereas overexpression of miR-29a down-regulated PTEN mRNA and protein 50. [score:11]
Additionally, we observed up-regulation of hsa-miR-29a-3p targets BCL2 and MCL1 at 24 h pi, where ssc-miR-29a was down-regulated. [score:9]
Among the targets for hsa-miR-29a-3p is PTEN, which was significantly down-regulated at both 24 h and 14d pi. [score:6]
Only four miRNAs (hsa-miR-223-5p, ssc-miR-31, ssc-miR-29a, and ssc-miR-182) were differentially expressed at 24 h pi, whereas 10 miRNAs were differentially expressed at 72 h pi (ssc-miR-29b, hsa-miR-203a-3p, hsa-miR-449a, ssc-miR-21, ssc-miR-29a, hsa-miR-23a-3p, ssc-miR-23b, ssc-miR-30c-5p, ssc-miR-423-5p, and hsa-miR-150-5p). [score:5]
It is however possible that Akt and FoxO protein functions are still affected by ssc-miR-29a regulation, given the effect that down-regulation of PTEN is likely to have on PTEN protein levels. [score:5]
Moreover, miR-29a inhibition negatively regulated phosphorylation of Akt (Protein Kinase B), which is an important step in the PI3K/AKT signaling pathway 50. [score:4]
Akt family member AKT2 as well as FOXO3A, a pro-apoptotic transcription factor (FoxO) downstream of PTEN and Akt, are also among the targets for hsa-miR-29a-3p. [score:3]
In all three post-challenge groups, at least three miRNAs were found to be unique for that particular time point, and only ssc-miR-29a was found to be differentially expressed at all three examined time points. [score:3]
ssc-miR-29a was the only miRNA to be regulated at all three time points. [score:2]
Collectively, our results highlight the importance of ssc-miR-29a in relation also to influenza, especially after infection, where it is involved in regulation of apoptosis, as has been described previously primarily in cancers 49. [score:2]
The miR-29 family is well characterised and commonly described to be involved in cancers as tumor suppressors 49. [score:1]
However, the highest number of significantly regulated miRNAs compared to before challenge was found at 14d pi, at which time point the infection had completely cleared (ssc-miR-15a, ssc-miR-29b, ssc-miR-29a, hsa-miR-449a, ssc-miR-186, ssc-miR-22-5p, ssc-miR-28-5p, hsa-miR-203a-3p, ssc-miR-146a-5p, hsa-miR-150-5p, ssc-miR-23b, hsa-miR-223-3p, hsa-miR-23a-3p, hsa-miR-16-5p). [score:1]
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2
[+] score: 45
In our study, CASP3 was significantly upregulated by qRT-PCR analysis (Figure 6) and targeted by the downregulated miRNAs: miR-342-3p, miR-29b, miR-29c, miR-29a, let-7g and miR-30b, which can be expected to develop miRNA -based therapeutics for influenza disease. [score:11]
Therefore, down-regulation of miR-29a, miR-29c and let-7g may contribute to the uncontrolled inflammation by allowing up-regulation of pro-inflammation genes. [score:7]
Therefore, the downregulated miR-29 may regulate the T helper 1 (Th1) cell differentiation to secrete more IFN-gamma and mediate elimination of intracellular pathogens, but dysregulated T cell responses may also contribute to pathologic inflammation. [score:6]
MiR-29a and miR-29b were reported to be downregulated in lung tissues from mice infected with reconstructed 1918 or a nonlethal seasonal influenza virus, Tx/91 [17]. [score:4]
E. K. Loveday et al. demonstrated that miR-29a, miR-29c and let-7g were down-regulated in human A549 cells infected with swine-origin influenza pandemic H1N1 [21]. [score:4]
Both miR-29a and miR-29b could repress IFN-gamma production by direct targeting of both T-box transcription factor T-bet and Eomesodermin (Eomes), two transcription factors known to induce IFN-gamma production [63]. [score:4]
validation of differentially expressed miRNAs and ROC analysisThe microarray data were validated by performing, qRT-PCR for nine miRNAs, including hsa-miR-146b-5p, hsa-miR-148a, hsa-miR-150, hsa-miR-31, hsa-miR-155, hsa-miR-29a, hsa-miR-29b, hsa-miR-342-5p, and hsa-miR-886-3p. [score:3]
The expression of hsa-miR-150, hsa-miR-31, hsa-miR-155, hsa-miR-29a, hsa-miR-29b, hsa-miR-342-5p, and hsa-miR-146b-5p were present in lower abundance, whereas hsa-miR-148a and hsa-miR-886-3p were present in higher abundance in PBMCs from critically ill patients infected with H1N1 influenza virus than that from healthy controls. [score:3]
The microarray data were validated by performing, qRT-PCR for nine miRNAs, including hsa-miR-146b-5p, hsa-miR-148a, hsa-miR-150, hsa-miR-31, hsa-miR-155, hsa-miR-29a, hsa-miR-29b, hsa-miR-342-5p, and hsa-miR-886-3p. [score:1]
ROC curve analyses revealed that miR-31, miR-29a and miR-148a were valuable biomarkers for differentiating critically ill patients from controls: miR-31 yielded an AUC (the areas under the ROC curve) of 0.9510 (95% CI: 0.8734–1.029; P = 0.0001884) with 81.82% sensitivity and 92.31% specificity in discriminating critically ill patients; miR-29a yielded AUC of 0.8951 (95% CI: 0.7412–1.049 P = 0.0001070) with 90.91% sensitivity and 92.31% specificity in discriminating critically ill patients, and miR-148a yielded AUC of 0.8811 (95% CI: 0.7360–1.026 P = 0.001601) with 72.73% sensitivity and 100% specificity in discriminating critically ill patients(Figure 5). [score:1]
ROC curve analyses revealed that miR-31, miR-29a and miR-148a all had significant potential diagnostic value for critically ill patients infected with H1N1 influenza virus, which yielded AUC of 0.9510, 0.8951 and 0.8811, respectively. [score:1]
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3
[+] score: 36
Other miRNAs from this paper: ssc-mir-122, ssc-mir-125b-2, ssc-mir-181b-2, ssc-mir-20a, ssc-mir-23a, ssc-mir-26a, ssc-mir-29b-1, ssc-mir-181c, ssc-mir-214, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-103-1, ssc-mir-107, ssc-mir-21, ssc-mir-29c, ssc-mir-30c-2, bta-mir-26a-2, bta-mir-29a, bta-let-7f-2, bta-mir-103-1, bta-mir-20a, bta-mir-21, bta-mir-26b, bta-mir-30d, bta-mir-499, bta-mir-99a, bta-mir-125b-1, bta-mir-126, bta-mir-181a-2, bta-mir-199a-1, bta-mir-30b, bta-mir-107, bta-mir-10a, bta-mir-127, bta-mir-142, bta-mir-181b-2, bta-mir-30e, bta-mir-92a-2, bta-let-7d, bta-mir-132, bta-mir-138-2, bta-mir-17, bta-mir-181c, bta-mir-192, bta-mir-199b, bta-mir-200a, bta-mir-200c, bta-mir-214, bta-mir-23a, bta-mir-29b-2, bta-mir-29c, bta-mir-455, bta-let-7g, bta-mir-10b, bta-mir-30a, bta-mir-200b, bta-let-7a-1, bta-let-7f-1, bta-mir-122, bta-mir-30c, bta-let-7i, bta-mir-25, bta-let-7a-2, bta-let-7a-3, bta-let-7b, bta-let-7c, bta-let-7e, bta-mir-103-2, bta-mir-125b-2, bta-mir-99b, ssc-mir-99b, ssc-mir-17, ssc-mir-30b, ssc-mir-199b, bta-mir-1-2, bta-mir-1-1, bta-mir-129-1, bta-mir-129-2, bta-mir-133a-2, bta-mir-133a-1, bta-mir-133b, bta-mir-135b, bta-mir-138-1, bta-mir-143, bta-mir-144, bta-mir-146b, bta-mir-146a, bta-mir-181d, bta-mir-190a, bta-mir-199a-2, bta-mir-202, bta-mir-206, bta-mir-211, bta-mir-212, bta-mir-223, bta-mir-26a-1, bta-mir-29d, bta-mir-30f, bta-mir-338, bta-mir-33a, bta-mir-33b, bta-mir-375, bta-mir-429, bta-mir-451, bta-mir-92a-1, bta-mir-92b, bta-mir-29e, bta-mir-29b-1, bta-mir-181a-1, bta-mir-181b-1, ssc-mir-133a-1, ssc-mir-1, ssc-mir-146b, ssc-mir-181a-1, ssc-mir-30a, bta-mir-199c, ssc-mir-206, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-133b, ssc-mir-30d, ssc-mir-30e, ssc-mir-199a-2, ssc-mir-499, ssc-mir-143, ssc-mir-10a, ssc-mir-10b, ssc-mir-103-2, ssc-mir-181a-2, ssc-mir-181b-1, ssc-mir-181d, ssc-mir-99a, ssc-mir-92a-2, ssc-mir-92a-1, ssc-mir-92b, ssc-mir-192, ssc-mir-142, ssc-mir-127, ssc-mir-202, ssc-mir-129a, ssc-mir-455, ssc-mir-125b-1, ssc-mir-338, ssc-mir-133a-2, ssc-mir-146a, bta-mir-26c, ssc-mir-30c-1, ssc-mir-126, ssc-mir-199a-1, ssc-mir-451, ssc-let-7a-2, ssc-mir-129b, ssc-mir-429, ssc-let-7d, ssc-let-7f-2, ssc-mir-29b-2, ssc-mir-132, ssc-mir-138, ssc-mir-144, ssc-mir-190a, ssc-mir-212, bta-mir-133c, ssc-mir-26b, ssc-mir-200b, ssc-mir-223, ssc-mir-375, ssc-mir-33b
In humans, the high expression of miR-129 in ovaries is associated with the control of cell growth and differentiation in the final process of ovary maturation through downregulation of its target mRNAs, whereas miR-29 expression levels, which progressively increase throughout oogenesis, may also be important (Sirotkin et al., 2009). [score:10]
Thus, miR-29a may be a future target in expression studies to improve filet quality with a high potential for applications in aquaculture. [score:5]
Furthermore, Qiang et al. (2017c) showed that miR-29a antagomir treatment in vivo resulted in stearoyl-CoA desaturase (SCD) upregulation, which plays a role in hepatic lipid metabolism regulation (Dobrzyn and Ntambi, 2004; Ntambi and Miyazaki, 2004). [score:5]
microRNA-29, a key regulator of collagen expression in systemic sclerosis. [score:4]
miR-29a modulates SCD expression and is regulated in response to a saturated fatty acid diet in juvenile genetically improved farmed tilapia (Oreochromis niloticus). [score:4]
miR-29a, which is highly conserved between Salmo salar and Danio rerio (Andreassen et al., 2013), is the major factor in collagen formation and showed low expression in human fibroblasts with systemic sclerosis (Maurer et al., 2010). [score:3]
For example, miR-29a acts in collagen formation as has conserved targets among fish, mouse and human, implying that this miRNA is a good candidate to be modulated in Tambaqui with the goal of improving filet quality. [score:3]
By contrast, the miR-29 and miR-129 families showed significantly increased expression in ovaries compared to testes (Xiao et al., 2014). [score:2]
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4
[+] score: 22
Other miRNAs from this paper: ssc-mir-26a, ssc-mir-27a, ssc-mir-1, ssc-mir-27b, ssc-mir-26b
Expressions of ANP, BNP, and miRNA-29a were up-regulated, while SERCA2a and miRNA-1 were down-regulated. [score:9]
b Significant alteration of the miRNA expression pattern was detected, including down regulation of miR-1 and upregulation of miR-29a in both ventricles. [score:7]
In addition, miR-29a expression was increased 2- to 3-fold in the RV and LV, respectively. [score:3]
Increased expression of miR-29a is consistently found in hypertrophic animal mo dels and in human heart failure and also with cardiac hypertrophy and fibrosis in hypertrophic cardiomyopathy patients [23], highlighting their use as potential biomarker. [score:3]
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5
[+] score: 19
In addition, the miR-29 family is associated with the up-regulation of the tumor suppressor p53, which is central to many cellular stress responses and for inducing apoptosis [31]. [score:6]
The second group, e. g. ; the miR-29 family (containing miR-29a –b –c) and miR-22, miR-24, miR-27b and miR-142-5p showed increasing expression with age progression, with a particularly high expression in the adult tissues. [score:5]
Therefore, it is plausible that miRNAs prominently expressed at this time (for instance miR-24 and the miR-29 family members) might regulate this process. [score:4]
Thus, miRNAs expressed at a high level in the adult brain (for instance let-7i, miR-22 and miR-29a-b and -c, miR-142-5p), could be involved in myelination, synapse formation and/or maintenance of synaptic plasticity. [score:3]
The miR-29 family (miR-29a, miR-29b and miR-29c) has previously been shown to be effective biomarkers of radiation -induced brain responses [29]. [score:1]
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6
[+] score: 19
The down-regulated miR-29b and miR-29a are both or each connected to up-regulated SMARCE1, HBO1, NKX6-1, HOXA10, HBP1, OTUD4, that could be further considered as potent targets during infection. [score:8]
Five miRNAs were nodal and were either up-regulated (miR-194 and miR-let7b) or down-regulated (miR-27B, miR29-a and miR29-b1). [score:7]
PRV infection was also associated to intense down-regulation (up to 31 folds) of tags mapping to the 28S ribosomal rRNA as well as of four miRNAs (miR-27b*, miR-29a, miR-29b-1* and miR-30e). [score:4]
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7
[+] score: 18
Other miRNAs from this paper: ssc-mir-29b-1, ssc-mir-29c, ssc-mir-29b-2
On the other hand, the secondary structure of MD18 could avoid the regulation by miR-29a-5p due to the inaccessibility of the target sequence as has been proposed for HIV [16]. [score:4]
The homology of the viral sequence with miR-29a-5p, with only one internal mismatch, led us to analyze with more detail if miR-29a-5p can regulate the expression of the Cap protein. [score:4]
A miR-29a-5p target prediction was evaluated using Miranda software [27] in order to explore if the Cap gen constitutes a target. [score:3]
The lack of the presence of G at position 1202 could be due to restriction in the protein conformation or due to the pressure exerted by miR-29a-5p in order to avoid regulation by this miRNA. [score:2]
Only one miRNA candidate was initially identified, but the posterior analysis indicated that it was a host miRNA, miR-29a-5p. [score:1]
In addition, further studies on the similarity of this candidate with miR-29a-5p, and its significance, could shed light on how miRNAs affect viral evolution [30]. [score:1]
Figure 3 Alignment of miR-29a-5p with positions 1188-1209 of the Sp-10-7-54-13 sequence and all PCV2 available sequences in the EMBL database. [score:1]
miR-29a-5p has been described in many species like human, bovine, mouse, but it has not been described in pigs, where the precursor miR-29 has been included in miRBase along with the mature ssc-miR-29a-3p. [score:1]
From the total reads obtained in this study, 1276 sequences of 22 nt, comprising the 18 nt of the candidate, blasted to the miR-29a-5p. [score:1]
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8
[+] score: 15
Downregulation of miR-1, miR-10a, miR-29a, and miR-208a has been implicated in chronic AF [7, 13, 59], while these miRNAs were highly upregulated in the porcine LA in response to brief paroxysms of AF. [score:7]
Pacing -induced alterations in the expression of other miRNAs with particular concern for their involvement in AF could not be determined by microarray hybridizations due to a high variability among replicates (miR-1, miR-21, miR-23a/b, miR-29a, and miR-133a) or very low hybridization signals (miR-10a, miR-10b; see the complete microarray data at NCBI through GEO accession number GSE65330). [score:3]
Our qPCR analysis showed that pacing resulted in a significant upregulation of a set of AF -associated miRNAs (i. e., miR-1, miR-10a, miR-10b, miR-21, miR-29a, and miR-208a) in the LA compared with the control (see Figure 3). [score:3]
Six miRNAs (miR-1, miR-10a-5p, miR-10b, miR-21, miR-29a, and miR-208a) showed a higher expression in paced as compared with nonpaced animals. [score:2]
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9
[+] score: 12
There were 17 DEMs, represented by miR-124 and miR-214, dominating the miRNA-regulated gene expression in the early metaphase of embryonic stage and 10 DEMs, miR-29 for instance, were highly expressed at the postnatal stage. [score:6]
Maurer B. Stanczyk J. Jungel A. Akhmetshina A. Trenkmann M. Brock M. Kowal-Bielecka O. Gay R. E. Michel B. A. Distler J. H. MicroRNA-29, a key regulator of collagen expression in systemic sclerosis Arthritis Rheumatol. [score:3]
Our results were consistent with previous studies, which demonstrated miR-29 targeting to the collagen family members such as COL4A1, COL1A2 and COL1A1 at ADU time points, miR-148 to the MITF and EIF4BP2 genes at early embryonic stage, and miR-487 to the IRS1 gene at the middle stage [23, 24]. [score:3]
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10
[+] score: 11
A study on the expression profile of novel miRNAs in 11 pig tissues, including brain, liver, heart, muscle, colon, kidney, lung, spleen, stomach, cervix and fibroblasts, indicated that ssc-miR-15b, ssc-miR-23a, ssc-miR-23b, ssc-miR-24, ssc-miR-29a, ssc-miR-30b, ssc-miR-145, and ssc-miR-152 are expressed in all tissues; ssc-miR-210 is mainly expressed in the liver, spleen, and stomach; ssc-miR-34a and ssc-miR-130a are mainly expressed in the lungs; and ssc-miR-140 is highly expressed in the cervix. [score:11]
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11
[+] score: 10
Secondly, targets for a sub-set of down-regulated miR (miR-15, miR-16, miR-27, miR-29, miR-34 and miR-106), of which 44 targets were identified based on our previous criteria were predicted (see Additional file 4). [score:8]
These miR have been implicated in multiple cellular processes including cell growth (miR-24), apoptosis (miR-16, miR-24 and miR-29), and cell cycle regulation in normal (miR-16) and cancerous cells (miR-24, miR-27, miR-29 and miR-34) [9, 40- 46]. [score:2]
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12
[+] score: 9
Of these, 40 miRNAs are minimally expressed (0 < average signals ≤ 100; p ≤ 0.01), 77 miRNAs are modestly expressed 100 < average signals ≤ 1,000; p ≤ 0.01), 85 miRNAs were highly expressed (1,000 < average signals ≤ 10,000), and, in particular, 20 miRNAs were extremely highly expressed in the anterior pituitary (average signals ≥ 10,000; p ≤ 0.01), including ssc-miR-7, Y-90, ssc-miR-26a, ssc-miR-125b, Y-1, ssc-miR-125a, Y-77, ssc-let-7g, ssc-miR-29a, ssc-let-7i, ssc-let-7a, ssc-let-7f, ssc-miR-148a, ssc-miR-21, ssc-miR-335, ssc-miR-30b-5p, ssc-miR-191, ssc-miR-29c, ssc-miR-23b, and ssc-miR-23a (Fig 1C). [score:9]
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13
[+] score: 7
MicroRNAs like miR-29a and miR-32 have been found to repress the expression of viral mRNAs by possible recognition and targeting of viral nucleic acids with miR-29 specifically targeting HIV-1 3’UTR region [11], [12]. [score:7]
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14
[+] score: 7
For example, miR-29, miR-181 and miR-148a can promote myoblast differentiation by inhibiting the expression of downstream target genes Akt3, Hox-A1 and ROCK1 at protein levels [10– 12]. [score:7]
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15
[+] score: 6
In addition to tissue-specific ageing, it is increasingly evident that many miRNA regulate gene expressions in well-known ageing pathways, most notably in the p53 tumor suppressor pathway (miR-34, miR-29 and miR-217, etc. ) [score:6]
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16
[+] score: 6
miR-29 negatively regulates skeletal myogenesis by targeting Ring1 and YY1 -binding protein (Rybp) [43]. [score:4]
Four miRNAs (ssc-miR-29a, ssc-miR-1, ssc-miR-128, ssc-miR-320) showed obviously enhanced expression at D100 compared to E90. [score:2]
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17
[+] score: 6
Hoeke et al. [18] showed that miR-29a was up-regulated after Salmonella infection and was a main regulator of the focal adhesion pathway and the actin cytoskeleton pathway. [score:5]
In addition to miR-146 and miR-155, the let-7, miR-15, miR-128 and miR-29a also have roles in Salmonella infection. [score:1]
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18
[+] score: 6
Another gene family that we evidenced prevalently expressed in the WBCs is mir-29 (mir-29a, mir-29b, mir-29c; p = 2.19 E-4). [score:3]
We found that miRNAs with higher expression in WBCs includes different miRNA families: mir-15, mir-17, mir-181, mir-23, mir-27 and mir-29 families. [score:3]
[1 to 20 of 2 sentences]
19
[+] score: 5
They furthermore demonstrated that hsa-miR-29 (especially hsa-miR-29b-3p) indirectly mediate IFNL1 up-regulation by controlling DNA methyltransferase (DNMT3A and DNMT3B) activity in human pulmonary epithelial cells (A549) and a subsequent IRF3/IRF7 dependent transcription of IFNL1 via COX2 (PTGS2), a potent inflammatory protein in IAV infection [69]. [score:5]
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20
[+] score: 5
A lecture showed that the inhibition of miR-29 by TGF-beta-Smad3 signaling through dual mechanisms promotes the trans-differentiation of mouse myoblasts into myofibroblasts [23]. [score:3]
In agreement with a previous study, miR-29a was also increased in abundance after birth [13]. [score:1]
In G2 (down), the most significant differences between breeds were observed at 2 dpn, when miR-29 and miR-499 showed drastic changes. [score:1]
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21
[+] score: 5
Also, overexpression of miR-29 promotes myogenic differentiation in C2C12 cells, due to the reduction in TGF-beta, which inhibits differentiation 42. [score:5]
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22
[+] score: 5
The up-regulation of miR-141, miR-200a, miR-200c, miR-26a, and miR-29 we detected were also accordant either with mice or with humans. [score:4]
Bak et al. reported 8 miRNAs (mir-7, mir-7b, mir-375, mir-141, mir-200a, mir-200c, mir-25and mir-152) with more than 3-fold enrichment in the pituitary of adult mice in a profile of the miRNAs in the central nervous system [36]; and Farh et al. and Landgraf et al. reported 6 (mir-7, mir-212, mir-26a, mir-191, mir-375 and mir-29) when comparing the miRNAs in normal and tumor pituitary cells [37], [38]. [score:1]
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23
[+] score: 5
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-21, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-26a-1, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-99a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-16-2, hsa-mir-192, hsa-mir-148a, hsa-mir-10b, hsa-mir-181a-2, hsa-mir-181a-1, hsa-mir-215, hsa-mir-223, hsa-mir-224, hsa-mir-200b, hsa-mir-15b, hsa-mir-27b, hsa-mir-125b-1, hsa-mir-141, hsa-mir-143, hsa-mir-152, hsa-mir-125b-2, hsa-mir-126, hsa-mir-146a, hsa-mir-184, hsa-mir-200c, hsa-mir-155, hsa-mir-29c, hsa-mir-200a, hsa-mir-99b, hsa-mir-296, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-378a, hsa-mir-342, hsa-mir-148b, hsa-mir-451a, ssc-mir-125b-2, ssc-mir-148a, ssc-mir-15b, ssc-mir-184, ssc-mir-224, ssc-mir-23a, ssc-mir-24-1, ssc-mir-26a, ssc-mir-29b-1, ssc-let-7f-1, ssc-mir-103-1, ssc-mir-21, ssc-mir-29c, hsa-mir-486-1, hsa-mir-499a, hsa-mir-671, hsa-mir-378d-2, bta-mir-26a-2, bta-mir-29a, bta-let-7f-2, bta-mir-103-1, bta-mir-148a, bta-mir-16b, bta-mir-21, bta-mir-499, bta-mir-99a, bta-mir-125b-1, bta-mir-126, bta-mir-181a-2, bta-mir-27b, bta-mir-31, bta-mir-15b, bta-mir-215, bta-mir-30e, bta-mir-148b, bta-mir-192, bta-mir-200a, bta-mir-200c, bta-mir-23a, bta-mir-29b-2, bta-mir-29c, bta-mir-10b, bta-mir-24-2, bta-mir-30a, bta-mir-200b, bta-let-7a-1, bta-mir-342, bta-let-7f-1, bta-let-7a-2, bta-let-7a-3, bta-mir-103-2, bta-mir-125b-2, bta-mir-15a, bta-mir-99b, hsa-mir-664a, ssc-mir-99b, hsa-mir-103b-1, hsa-mir-103b-2, ssc-mir-15a, ssc-mir-16-2, ssc-mir-16-1, bta-mir-141, bta-mir-143, bta-mir-146a, bta-mir-152, bta-mir-155, bta-mir-16a, bta-mir-184, bta-mir-24-1, bta-mir-223, bta-mir-224, bta-mir-26a-1, bta-mir-296, bta-mir-29d, bta-mir-378-1, bta-mir-451, bta-mir-486, bta-mir-671, bta-mir-29e, bta-mir-29b-1, bta-mir-181a-1, ssc-mir-181a-1, ssc-mir-215, ssc-mir-30a, bta-mir-2318, bta-mir-2339, bta-mir-2430, bta-mir-664a, bta-mir-378-2, ssc-let-7a-1, ssc-mir-378-1, ssc-mir-30e, ssc-mir-499, ssc-mir-143, ssc-mir-10b, ssc-mir-486-1, ssc-mir-152, ssc-mir-103-2, ssc-mir-181a-2, ssc-mir-27b, ssc-mir-24-2, ssc-mir-99a, ssc-mir-148b, ssc-mir-664, ssc-mir-192, ssc-mir-342, ssc-mir-125b-1, oar-mir-21, oar-mir-29a, oar-mir-125b, oar-mir-181a-1, hsa-mir-378b, hsa-mir-378c, ssc-mir-296, ssc-mir-155, ssc-mir-146a, bta-mir-148c, ssc-mir-126, ssc-mir-378-2, ssc-mir-451, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-451b, hsa-mir-499b, ssc-let-7a-2, ssc-mir-486-2, hsa-mir-664b, hsa-mir-378j, ssc-let-7f-2, ssc-mir-29b-2, ssc-mir-31, ssc-mir-671, bta-mir-378b, bta-mir-378c, hsa-mir-486-2, oar-let-7a, oar-let-7f, oar-mir-103, oar-mir-10b, oar-mir-143, oar-mir-148a, oar-mir-152, oar-mir-16b, oar-mir-181a-2, oar-mir-200a, oar-mir-200b, oar-mir-200c, oar-mir-23a, oar-mir-26a, oar-mir-29b-1, oar-mir-30a, oar-mir-99a, bta-mir-664b, chi-let-7a, chi-let-7f, chi-mir-103, chi-mir-10b, chi-mir-125b, chi-mir-126, chi-mir-141, chi-mir-143, chi-mir-146a, chi-mir-148a, chi-mir-148b, chi-mir-155, chi-mir-15a, chi-mir-15b, chi-mir-16a, chi-mir-16b, chi-mir-184, chi-mir-192, chi-mir-200a, chi-mir-200b, chi-mir-200c, chi-mir-215, chi-mir-21, chi-mir-223, chi-mir-224, chi-mir-2318, chi-mir-23a, chi-mir-24, chi-mir-26a, chi-mir-27b, chi-mir-296, chi-mir-29a, chi-mir-29b, chi-mir-29c, chi-mir-30a, chi-mir-30e, chi-mir-342, chi-mir-378, chi-mir-451, chi-mir-499, chi-mir-671, chi-mir-99a, chi-mir-99b, bta-mir-378d, ssc-mir-378b, oar-mir-29b-2, ssc-mir-141, ssc-mir-200b, ssc-mir-223, bta-mir-148d
Members of the miRNA-29 family have been shown to revert aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B (Fabbri et al., 2007). [score:3]
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. [score:2]
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[+] score: 4
Many miRNAs, such as miR-1, miR-133, miR-29, miR-214, miR-206, miR-486, miR-208b, and miR-499 were involved in the regulation of skeletal myogenesis by binding to its target genes 36, 37. [score:4]
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[+] score: 4
Wei W. He H. B. Zhang W. Y. Zhang H. X. Bai J. B. Liu H. Z. Cao J. H. Chang K. C. Li X. Y. Zhao S. H. miR-29 targets Akt3 to reduce proliferation and facilitate differentiation of myoblasts in skeletal muscle development Cell Death Dis. [score:4]
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[+] score: 3
Of these, 2 (miR-29a, 99a) followed the differences seen by microarray in direction and magnitude (p<0.05), 1 (miR-323) opposed results seen by microarray (p<0.05), and no significant differences were observed for the remaining miRNAs. [score:2]
ssc-miR-10a (JX185556); ssc-miR-29a (JX185557); ssc-miR-30b-5p (JX185558); ssc-miR-99a (JX185559); ssc-miR-148b (JX185560); ssc-miR-323 (JX185552); ssc-miR-331-5p (JX185553); ssc-miR-339-3p (JX185554); ssc-miR-374b-5p (JX185562); RNU1A (JN617883); AhR (KC012627), CCNG1 (KC012621); CDC42 (KC012622); DNMT3A (KC012620); FADD (KC012625); FOXO1 (KC012619); GPR37 (KC012626); IFI30 (KC012618); MMD (KC012628); USF2 (KC012623); USP46 (KC012624). [score:1]
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[+] score: 3
Other miRNAs from this paper: hsa-mir-29a, dre-mir-29a
Chen X, Ouyang L, Yin Z, Xia Y, Chen X, Shi H, et al. Effects of microRNA-29a on retinopathy of prematurity by targeting AGT in a mouse mo del. [score:3]
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[+] score: 3
Infection of porcine dendritic cells (DCs) with the alphaherpesvirus pseudorabies virus alters the expression of several cellular miRNAs, including miR-27b*, miR-29a and miR-30e-3p [3]. [score:3]
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[+] score: 3
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-26a-1, hsa-mir-27a, hsa-mir-29a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-199a-1, hsa-mir-208a, hsa-mir-148a, hsa-mir-10a, hsa-mir-181a-2, hsa-mir-181c, hsa-mir-199a-2, hsa-mir-181a-1, hsa-mir-214, hsa-mir-221, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-23b, hsa-mir-27b, hsa-mir-125b-1, hsa-mir-128-1, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-143, hsa-mir-125b-2, hsa-mir-126, hsa-mir-127, hsa-mir-206, hsa-mir-1-1, hsa-mir-128-2, hsa-mir-29c, hsa-mir-26a-2, hsa-mir-378a, hsa-mir-148b, hsa-mir-133b, hsa-mir-424, ssc-mir-125b-2, ssc-mir-148a, ssc-mir-23a, ssc-mir-24-1, ssc-mir-26a, ssc-mir-29b-1, ssc-mir-181c, ssc-mir-214, ssc-mir-27a, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-103-1, ssc-mir-128-1, ssc-mir-29c, hsa-mir-486-1, hsa-mir-499a, hsa-mir-503, hsa-mir-411, hsa-mir-378d-2, hsa-mir-208b, hsa-mir-103b-1, hsa-mir-103b-2, ssc-mir-17, ssc-mir-221, ssc-mir-133a-1, ssc-mir-1, ssc-mir-503, ssc-mir-181a-1, ssc-mir-206, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-378-1, ssc-mir-133b, ssc-mir-199a-2, ssc-mir-128-2, ssc-mir-499, ssc-mir-143, ssc-mir-10a, ssc-mir-486-1, ssc-mir-103-2, ssc-mir-181a-2, ssc-mir-27b, ssc-mir-24-2, ssc-mir-23b, ssc-mir-148b, ssc-mir-208b, ssc-mir-424, ssc-mir-127, ssc-mir-125b-1, hsa-mir-378b, hsa-mir-378c, ssc-mir-411, ssc-mir-133a-2, ssc-mir-126, ssc-mir-199a-1, ssc-mir-378-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-499b, ssc-let-7a-2, ssc-mir-486-2, hsa-mir-378j, ssc-let-7d, ssc-let-7f-2, ssc-mir-29b-2, hsa-mir-486-2, ssc-mir-378b
PLOS ONE 7. 122 van Rooij E, Sutherland LB, Thatcher JE, DiMaio JM, Naseem RH et al. (2008) Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. [score:2]
In addition to the best-studied myomiRs (miR-1, -206 and miR-133 families), 11 other DE muscle-related miRNAs (miR-378 [24], miR-148a [27], miR-26a [28, 29], miR-27a/b [30, 31], miR-23a [32, 33], miR-125b [34], miR-24 [35], miR-128 [36], miR-199a [37] and miR-424 [38]) with high abundance (average RPM >1,000) and another 14 (miR-181a/b/c/d-5p [26], miR-499-5p [11], miR-503 [38], miR-486 [39], miR-214 [40], miR-29a/b/c [41– 43], miR-221/222 [44] and miR-208 [11] with low abundance (average RPM <1,000) were detected in myogenesis of pig. [score:1]
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[+] score: 1
For instance, BUN, a biomarker for kidney and liver function, was correlated with miR-145, miR-18, miR-29a and miR-671. [score:1]
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[+] score: 1
miR-29 was decreased in dogs with ventricular tachypacing -induced congestive heart failure (CHF) and in patients with CHF or AF [28]. [score:1]
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[+] score: 1
Other miRNAs from this paper: hsa-mir-29a, mmu-mir-29a
We also detected a third correspondence between the HDL45 TAR at SSC18 (20-22 Mb), exclusively detected with GenABEL, and one region at human 7q32 that contains a microRNA-encoding gene (miR-29A) strongly associated (1 × 10 [-15]) with HDL levels [24]. [score:1]
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