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15 publications mentioning hsa-mir-1233-2

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-1233-2. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 53
Among the 77 miRNAs, 7 miRNAs, hsa-miR-33b-3p, hsa-miR-4284, hsa-miR-663a, hsa-miR-150-5p, hsa-miR-1233-3p, hsa-miR-671-3p, and hsa-miR-140-3p, were selected for further validation based on the fact that they were in the top 20 up- or downregulated miRNAs as found in microarray microRNA expression profiling presented in Fig.   1a, b. More specifically, miR-33b-3p and miR-4284 were among the top upregulated, and miR-663a, miR150-5p, miR-1233-3p, miR-671-3p, and miR-140-3p were downregulated. [score:12]
The expression levels of hsa-miR-33b-3p and hsa-miR-4284 coincided between the two methodologies, while hsa-miR-1233-3p, hsa-miR-140-3p, hsa-miR-150-5p, hsa-miR-663a, and hsa-miR-671-3p were marginally overexpressed in microarray analysis and appeared to be down-regulated with qRT-PCR Moreover, we found that hsa-miR-33b-3p and hsa-miR-4284 expression levels coincided between microarray analysis and qRT-PCR, exhibiting decreased expression in serum of OA samples compared to controls. [score:11]
The expression levels of hsa-miR-33b-3p and hsa-miR-4284 coincided between the two methodologies, while hsa-miR-1233-3p, hsa-miR-140-3p, hsa-miR-150-5p, hsa-miR-663a, and hsa-miR-671-3p were marginally overexpressed in microarray analysis and appeared to be down-regulated with qRT-PCR Moreover, we found that hsa-miR-33b-3p and hsa-miR-4284 expression levels coincided between microarray analysis and qRT-PCR, exhibiting decreased expression in serum of OA samples compared to controls. [score:11]
We, next, validated with qRT-PCR, which offers high accuracy, sensitivity, and dynamic range [46] the expression levels of 7 selected out of the 77 DE miRNAs, which were among the top 20 up- or downregulated in the microarray screening, namely, hsa-miR-33b-3p, hsa-miR-4284, hsa-miR-663a, hsa-miR-150-5p, hsa-miR-1233-3p, hsa-miR-140-3p, and hsa-miR-671-3p, in serum and in OA and healthy articular cartilage samples. [score:6]
Hsa-miR-663a, hsa-miR-150-5p, hsa-miR-1233-3p, hsa-miR-140-3p, and hsa-miR-671-3p, which were marginally over-expressed in microarray analysis, appeared to be downregulated with qRT-PCR. [score:6]
Hsa-miR-1233-3p (a), hsa-miR-140-3p (b), hsa-miR-150-5p (c), hsa-miR-33-3p (d), hsa-miR-4284 (e), hsa-miR-663a (f), and hsa-miR-671-3p (g) manifested an area under the curve (AUC) value > 0.8 (AUC > 0.8) and p < 0.01 We verified by qRT-PCR the expression levels of the seven selected miRNAs (hsa-miR-33b-3p, hsa-miR-4284, hsa-miR-663a, hsa-miR-150-5p, hsa-miR-1233-3p, hsa-miR-140-3p, and hsa-miR-671-3p) in all serum samples. [score:3]
No significant differences were observed for hsa-miR-33-3p, hsa-miR-4284, hsa-miR-663a, and hsa-miR-1233-3p expression levels between OA and healthy articular cartilage. [score:3]
The expression levels of 7 selected miRNAs screened with miRNA microarrays, as mature hsa-miR-33b-3p, hsa-miR-4284, hsa-miR-663a, hsa-miR-150-5p, hsa-miR-1233-3p, hsa-miR-140-3p, and hsa-miR-671-3p, were evaluated in serum samples from 12 OA patients and 12 healthy controls. [score:1]
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2
[+] score: 40
The significance of the differences in the expression was confirmed for six of the miRNAs, including two down-regulated miRNAs namely miR-181d-5p and miR-206 and four up-regulated miRNA namely miR-1233-3p, miR-183-5p, miR-421 and miR-625-5p) (P < 0.05) (Fig.   3). [score:9]
Expression levels of miR-421, miR-1233-3p and miR-625-5p are lower in TOF patients with symptomatic right heart failure and thus may indicate disease progression in these patients. [score:5]
Moreover, differential expression levels of miR-421, miR-1233-3p and miR-625-5p were found in TOF-noHF and TOF-HF patients with significantly reduced expression levels in TOF patients with symptomatic right heart failure (Fig.   4). [score:5]
The RT-qPCR showed the same direction of expression changes as the microarray analysis for six miRNAs namely miR-181d-5p, miR-142-5p, miR-1233-3p, miR-206, miR-339-5p and miR-625-5p. [score:4]
The RT-qPCR showed the same direction of expression changes as the microarray analysis for six miRNAs namely miR-181d-5p, miR-1233-3p, miR-183-5p, miR-206, miR-421 and miR-625-5p. [score:4]
We found that expression levels of circulating miR-421, miR-1233-3p and miR-625-5p were significantly lower in TOF patients with as compared to those without symptomatic right heart failure indicating a potential role of these miRNAs in identifying disease progression in TOF patients. [score:4]
In addition, we selected three miRNAs (miR-1233-3p, miR-140-3p and miR-421) with low or moderate expression levels in the three comparisons and miR-421 that had been identified in TOF [9]. [score:3]
For further analysis of the patient group, we additionally selected three miRNAs (miR-1233-3p, miR-140-3p and miR-421) with low or moderate expression levels in the three comparisons and miR-421 that had been identified in myocardial tissue of TOF patients [9]. [score:3]
Moreover, expression levels of miR-625-5p, miR-1233-3p and miR-421 were lower in TOF-HF compared to TOF-noHF (P = 0.012). [score:2]
However, weak correlations were observed between miR-421 and miR-1233-5p and right ventricular volumes, ejection fraction as well as hsTNT (Table  3). [score:1]
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3
[+] score: 21
The expression of hsa-miR-103a-3p, hsa-miR-211, hsa-miR-296-5p, hsa-miR-1233 and hsa-miR-1267 in whole saliva and the absence of these miRNAs in parotid saliva suggest that these miRNAs are not specifically expressed and/or secreted from the parotid gland tumor. [score:5]
Of these, 5 miRNAs (hsa-miR-296-5p, hsa-miR-577, hsa-miR-1233, hsa-miR-1267, and hsa-miR-1825) had a significantly higher expression level (lower ΔCt) in whole saliva samples from patients with a parotid gland neoplasm compared to their expression levels in whole saliva from healthy controls. [score:4]
Four of the five tumor-specific miRNAs (hsa-miR-296-5p, hsa-miR-1233, hsa-miR-1267, and hsa-miR-1825) had a significantly higher expression level in whole saliva from patients than in whole saliva from healthy controls (Table 3). [score:3]
A box-and-whisker plot predicting the probability of neoplasm (Fig 3B) was constructed based on the validation data of a 2 miRNA combination (hsa-miR-1233 and hsa-miR-211). [score:1]
B. Predicted probability of neoplasm was based on validation data of 2 validated miRNAs (hsa-miR-211 and hsa-miR-1233). [score:1]
miRNA ΔCt control mean (sd) ΔCt neoplasm mean (sd) Wilcoxon 2-sided p-value hsa-miR-103a-3p 6.34 (1.71) ND < 0.001 hsa-miR-211 9.45 (1.38) ND < 0.001 hsa-miR-425-5p 11.56 (3.72) ND < 0.001 hsa-miR-296-5p ND 7.41 (3.75) < 0.001 hsa-miR-577 ND 5.96 (3.44) < 0.001 hsa-miR-1233 19.14 (4.98) 8.93 (8.49) 0.002 hsa-miR-1267 ND 3.87 (2.79) < 0.001 hsa-miR-1825 20.94 (2.26) 5.17 (5.38) < 0.001 ND: non-detectable, assigned to samples with a Ct-value of 40 and higher. [score:1]
The full mo del included 7 miRNAs (hsa-miR-103a-3p, hsa-miR-211, hsa-miR-296-5p, hsa-miR-425-5p, hsa-miR-1233, hsa-miR-1267 and hsa-miR-1825). [score:1]
miRNA ΔCt control mean(sd) ΔCt neoplasm mean (sd) Wilcoxon 2-sided p-value hsa-miR-103a-3p 14.32 (3.59) 10.00 (4.75) < 0.001 hsa-miR-211 14.91 (3.18) 8.56 (4.37) < 0.001 hsa-miR-296-5p 12.80 (4.15) 6.95 (4.66) < 0.001 hsa-miR-425-5p 9.96 (5.13) 2.54 (4.79) < 0.001 hsa-miR-577 10.19 (1.57) 9.66 (2.85) 0.650 hsa-miR-1233 15.74 (0.70) 9.17 (6.89) < 0.001 hsa-miR-1267 9.78 (5. 03) 4.39 (5.21) < 0.001 hsa-miR-1825 7.47 (7.46) -0.77 (3.95) < 0.001 Multivariate logistic regression mo dels with these miRNA biomarkers were constructed for the classification of patient samples into parotid gland neoplasm and healthy categories. [score:1]
The full mo del with 7 miRNA markers (hsa-miR-103a-3p, hsa-miR-211, hsa-miR-296-5p, hsa-miR-425-5p, hsa-miR-1233, hsa-miR-1267 and hsa-miR-1825) yielded an AUC of 0.95 (95% CI: 0.88–1.00), a sensitivity of 93% and a specificity of 86%. [score:1]
miRNA ΔCt control mean(sd) ΔCt neoplasm mean (sd) Wilcoxon 2-sided p-value hsa-miR-103a-3p 14.32 (3.59) 10.00 (4.75) < 0.001 hsa-miR-211 14.91 (3.18) 8.56 (4.37) < 0.001 hsa-miR-296-5p 12.80 (4.15) 6.95 (4.66) < 0.001 hsa-miR-425-5p 9.96 (5.13) 2.54 (4.79) < 0.001 hsa-miR-577 10.19 (1.57) 9.66 (2.85) 0.650 hsa-miR-1233 15.74 (0.70) 9.17 (6.89) < 0.001 hsa-miR-1267 9.78 (5. 03) 4.39 (5.21) < 0.001 hsa-miR-1825 7.47 (7.46) -0.77 (3.95) < 0.001 Samples were collected from patients with a parotid gland neoplasm (n = 46) and controls (n = 14). [score:1]
The reduced final mo del included hsa-miR-2 and hsa-miR-1233, which in combination provided satisfactory prediction while being parsimonious. [score:1]
A combination of two of these miRNAs (hsa-miR-1233 and hsa-miR-211) enabled a predictive value with a sensitivity of 91%, and a specificity of 86% for predicting the presence of a parotid gland neoplasm. [score:1]
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4
[+] score: 17
For instance, the hsa-mir-1233 family was found to be related to golgi autoantigen, golgin subfamily a, 6 pseudogenes, which are expressed in fetal brain (hypothalamus) and embryonic stem cells (Additional files 5 and 6). [score:3]
Interestingly, we found that for the hsa-mir-1233 family, the conserved mature microRNA sequences (an 82-bp fragment) in all the paralogs were found to be missing from the cDNA sequences deposited in the database (Figure 3b). [score:1]
In the region around 200–258 bp corresponding to conserved sequences to two microRNAs (in red frame), hsa-mir1233-1 and hsa-mir1233-2 (100% identity as indicated), we can see multiple genomic fragments, which are short and isolated, but highly conserved (percentage of identity can be found in Additional file 2). [score:1]
Two microRNA families (hsa-mir-1233 and hsa-mir-622) appear to be further expanded in the human genome, and were confirmed by fluorescence in situ hybridization. [score:1]
For instance, for the microRNA family hsa-mir-1233, multiple isolated and conserved genomic fragments shorter than 1 kb could contain potential microRNA paralogs (Figure 1). [score:1]
To validate the results obtained by computational prediction, we selected two probes for the two microRNA families (hsa-mir-1233 and hsa-mir-622), and labeled them with TAMRA (red) and FITC (green), respectively (Additional file 11). [score:1]
For instance, in two microRNA families, hsa-mir-1233 and hsa-mir-1244 (Figure 3, Additional file 7), we can clearly see that most of the microRNA paralogs had nearly identical mature sequences, while others demonstrate dissimilar features. [score:1]
One of them was identified previously (hsa-mir-1233), and one novel microRNA family (hsa-mir-622) detected in this study. [score:1]
Click here for file cDNA evidence for miRNA paralogs (hsa-mir-1233 family). [score:1]
The hsa-mir-1233 mainly clustered on chromosome 15 expanded further in the human genome. [score:1]
c. hsa-mir-1233 family (Red). [score:1]
cDNA evidence for miRNA paralogs (hsa-mir-1233 family). [score:1]
a. Multiple sequence alignment for microRNA paralog family hsa-mir-1233. [score:1]
Figure 1 Detailed local genomic sequence analyses reveal new patterns of expanded microRNA families (hsa-mir-1233). [score:1]
Fluorescence in situ hybridizationTo validate the results obtained by computational prediction, we selected two probes for the two microRNA families (hsa-mir-1233 and hsa-mir-622), and labeled them with TAMRA (red) and FITC (green), respectively (Additional file 11). [score:1]
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5
[+] score: 10
CNV region position genotypes CNV ID functional relevance expression (mimiRNA/[18] ) conservation mir-1977 chr1:556050-556128 chrM chr1:554403-560267 2,3,4 3.1 not reported/NA primates mir-1324 chr3:75762604-75762699 chr3:75464498-75782745 1,2 1432.2 not reported/NA primates mir-548i-2 chr4:9166887-9167035 chr4:9117494-9354801 1,2 1815.3 not reported/NA primates mir-1275 chr6:34075727-34075806 chr6:34071086-34077139 1,2 2853.12) upregulated in blood cells of MS patients [41] not reported/NA primates mir-1302-2 chr9:20144-20281 chr1, 15,19 chr9:485-38531 2,3 4134_full not reported/NA primates mir-1233 chr15:32461562-32461643 chr15 chr15:32450046-32662643 2,3,4,5 6351.3 1) not reported/NA primates mir-1233 chr15:32607783-32607864 chr15 chr15:32450046-32662643 2,3,4,5 6351.3 1) not reported/NA primates mir-650 chr22:21495270-21495365 chr22:20711019-21578950 0,1,2 8103_full 1) in several tissues (mostly ovary and ovary-derived cancers)/high primatesdupl. [score:6]
CNV region position genotypes CNV ID functional relevance expression (mimiRNA/[18] ) conservation mir-1268 chr15:20014593-20014644 chr15:19803370-20089386 2,3,4,5,6 20571) recurrently deleted in classical Hodgkin's lymphoma [47] not reported/NA primates mir-1233 chr15:32607783-32607864 chr15 chr15:32487975-32617680 0,1,2,3 2082 1) not reported/NA primates mir-1972 chr16:15011679-15011755 chr16 chr16:14897364-15016088 2,3,4 2141 not reported/NA primates mir-384 chrX:76056092-76056179 chrX:76053855-76057477 0,1,2 2648 in several tissues/NA mammals miRNAs localized in 'polymorphic-DC' CNV regions miRNA ID miRNA position dupl. [score:3]
Among the identified miRNA-CNVs, we found deletions (e. g., hsa-mir-384 and hsa-mir-1324), duplications (e. g., hsa-mir-1972 and hsa-mir-1977), and multiple duplications (multiallelic polymorphisms; e. g., hsa-mir-1233 and hsa-mir-1268). [score:1]
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6
[+] score: 7
The top 8 downregulated (hsa-miR-200c, hsa-miR-212, hsa-miR-29a, hsa-miR-532, hsa-miR-141, hsa-miR-1, hsa-miR-363, hsa-miR-187) and 8 upregulated (hsa-miR-487, hsa-miR-452, hsa-miR-1233, hsa-miR-92a, hsa-miR-106b, hsa-miR-1290, hsa-miR-320, hsa-miR-26a) miRNAs were presented in Figure 1A. [score:7]
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7
[+] score: 5
In addition, besides expression of 18 EBV-BART transcripts, 10 cellular miRNAs (miR-16, miR-26a, miR-142-5p, miR-148a, miR-200b, miR-223, miR-668, miR-877, miR-1178, and miR-1233) were shown to have an elevated expression pattern in EBV positive ID-BL [75]. [score:5]
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8
[+] score: 4
Additional precursor sequences of miRNAs containing in dels include miR-520h [39], [40], [41], miR-486 [42], miR-489 [43], miR-223 [44], miR-373 [45], miR-630 [46] and miR-1233 [17], which have been shown to be involved in cancer development, and miR-631, which is associated with risk of coronary artery disease [47]. [score:4]
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9
[+] score: 4
Reportedly, up-regulated miR-210 in the placenta has been associated with the pathogenesis of PE[3], and miR-1233 might be a potential biomarker of early PE[4]. [score:4]
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10
[+] score: 3
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-18a, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-21, hsa-mir-22, hsa-mir-26a-1, hsa-mir-29a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-93, hsa-mir-99a, hsa-mir-101-1, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-106a, hsa-mir-16-2, hsa-mir-197, hsa-mir-199a-1, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-10a, hsa-mir-34a, hsa-mir-182, hsa-mir-199a-2, hsa-mir-205, hsa-mir-210, hsa-mir-221, hsa-mir-223, hsa-let-7g, hsa-let-7i, hsa-mir-15b, hsa-mir-23b, hsa-mir-122, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-125b-1, hsa-mir-132, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-140, hsa-mir-142, hsa-mir-143, hsa-mir-125b-2, hsa-mir-134, hsa-mir-146a, hsa-mir-150, hsa-mir-206, hsa-mir-155, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-101-2, hsa-mir-130b, hsa-mir-26a-2, hsa-mir-361, hsa-mir-362, hsa-mir-363, hsa-mir-376c, hsa-mir-371a, hsa-mir-375, hsa-mir-376a-1, hsa-mir-378a, hsa-mir-342, hsa-mir-151a, hsa-mir-324, hsa-mir-335, hsa-mir-345, hsa-mir-423, hsa-mir-483, hsa-mir-486-1, hsa-mir-146b, hsa-mir-202, hsa-mir-432, hsa-mir-494, hsa-mir-495, hsa-mir-193b, hsa-mir-497, hsa-mir-455, hsa-mir-545, hsa-mir-376a-2, hsa-mir-487b, hsa-mir-551a, hsa-mir-571, hsa-mir-574, hsa-mir-576, hsa-mir-606, hsa-mir-628, hsa-mir-629, hsa-mir-411, hsa-mir-671, hsa-mir-320b-1, hsa-mir-320c-1, hsa-mir-320b-2, hsa-mir-378d-2, hsa-mir-889, hsa-mir-876, hsa-mir-744, hsa-mir-885, hsa-mir-920, hsa-mir-937, hsa-mir-297, hsa-mir-1233-1, hsa-mir-1260a, hsa-mir-664a, hsa-mir-320c-2, hsa-mir-2861, hsa-mir-378b, hsa-mir-1260b, hsa-mir-378c, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-664b, hsa-mir-378j, hsa-mir-486-2
A combination of six circulating plasma miRNAs (miR-125b, miR-34a, miR-21, miR-1233, miR-130b, and miR-146a) could be used to predict the development of central nervous system disease in a macaque/SIV mo del, when animal samples from pre- and post-infection were compared to HC (212). [score:3]
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11
[+] score: 3
For example, miR-1233 has been identified as a potential biomarker for renal cell carcinoma (RCC) by using the technique of TaqMan Low Density Array and confirmed to be highly expressed in RCC patients by using quantitative real-time PCR [48]. [score:3]
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12
[+] score: 1
This analysis included miR-184, miR-548a-5p, miR-574-3p, miR-616, miR-1233, miR-642, miR-140-3p, miR-517b, miR-10b and miR-380-3p (Figure  3, Tables  3 and 4 and Additional file 3: Table S3). [score:1]
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13
[+] score: 1
Nineteen out of 21 patients present at least one CNV-miRNA; some miRNAs are present only in deleted (i. e., miRNA6891, miRNA4650-2, miRNA5007, miRNA12331-1, miRNA1233-2), some only in duplicated (miRNA3914-1, miRNA3914-2, miRNA6761, miRNA650, miRNA6817, miRNA1256) and some in both (miRNA3675, miRNA570; Tables 2, 3). [score:1]
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14
[+] score: 1
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7e, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-18a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-21, hsa-mir-22, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-27a, hsa-mir-30a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-99a, hsa-mir-100, hsa-mir-101-1, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-106a, hsa-mir-16-2, hsa-mir-192, hsa-mir-196a-1, hsa-mir-199a-1, hsa-mir-148a, hsa-mir-10a, hsa-mir-196a-2, hsa-mir-199a-2, hsa-mir-203a, hsa-mir-215, hsa-mir-221, hsa-mir-222, hsa-mir-223, hsa-mir-200b, hsa-mir-1-2, hsa-mir-15b, hsa-mir-27b, hsa-mir-122, hsa-mir-125b-1, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-141, hsa-mir-143, hsa-mir-145, hsa-mir-152, hsa-mir-191, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-126, hsa-mir-127, hsa-mir-146a, hsa-mir-150, hsa-mir-185, hsa-mir-194-1, hsa-mir-195, hsa-mir-320a, hsa-mir-200c, hsa-mir-1-1, hsa-mir-155, hsa-mir-128-2, hsa-mir-194-2, hsa-mir-200a, hsa-mir-101-2, hsa-mir-130b, hsa-mir-302c, hsa-mir-375, hsa-mir-378a, hsa-mir-148b, hsa-mir-324, hsa-mir-451a, hsa-mir-483, hsa-mir-484, hsa-mir-486-1, hsa-mir-500a, hsa-mir-92b, hsa-mir-595, hsa-mir-596, hsa-mir-421, hsa-mir-378d-2, hsa-mir-744, hsa-mir-885, hsa-mir-939, hsa-mir-940, hsa-mir-1229, hsa-mir-1233-1, hsa-mir-1290, hsa-mir-1246, hsa-mir-103b-1, hsa-mir-103b-2, hsa-mir-718, hsa-mir-378b, hsa-mir-378c, hsa-mir-4306, hsa-mir-4286, hsa-mir-500b, hsa-mir-3935, hsa-mir-642b, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-3976, hsa-mir-4644, hsa-mir-203b, hsa-mir-451b, hsa-mir-378j, hsa-mir-486-2
Several circulating miRNAs were identified as biomarkers for the detection and diagnosis of GC: miR-21, miR-200c, miR-421, miR-199a, miR-122, miR-192, miR-222, miR-16, miR-25, miR-92a, miR-451, miR-486-5p, miR-940, miR-223, miR-19b, miR-194, miR-141, and miR-1233, with a reasonable degree of diagnostic ability [25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36]. [score:1]
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15
[+] score: 1
Other miRNAs from this paper: hsa-let-7b, hsa-mir-15a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-27a, hsa-mir-28, hsa-mir-30a, hsa-mir-100, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-181a-2, hsa-mir-210, hsa-mir-181a-1, hsa-mir-221, hsa-mir-1-2, hsa-mir-15b, hsa-mir-30b, hsa-mir-122, hsa-mir-132, hsa-mir-141, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-195, hsa-mir-200c, hsa-mir-1-1, hsa-mir-30c-1, hsa-mir-34b, hsa-mir-34c, hsa-mir-30e, hsa-mir-371a, hsa-mir-372, hsa-mir-373, hsa-mir-375, hsa-mir-151a, hsa-mir-429, hsa-mir-449a, hsa-mir-483, hsa-mir-193b, hsa-mir-520e, hsa-mir-520f, hsa-mir-520a, hsa-mir-520b, hsa-mir-520c, hsa-mir-520d, hsa-mir-520g, hsa-mir-520h, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-449b, hsa-mir-151b, hsa-mir-320b-1, hsa-mir-320b-2, hsa-mir-891a, hsa-mir-935, hsa-mir-1233-1, hsa-mir-548e, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-1275, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-1973, hsa-mir-548q, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-371b, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
The others are linked to cancer and aging (hsa-miR-30b-5p, hsa-miR-30c-5p, hsa-miR-375, hsa-miR-19b-3p, hsa-miR-200c-3p), or to unknown biological functions (hsa-miR-891a, hsa-miR-1233-3p) (see Table  1) [46]. [score:1]
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