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miRBase |
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![]() 6 publications mentioning hsa-mir-4485Open access articles that are associated with the species Homo sapiens and mention the gene name mir-4485. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary. |
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Other miRNAs from this paper: hsa-mir-23a, hsa-mir-29a, hsa-mir-100, hsa-mir-34a, hsa-mir-183, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-206, hsa-mir-155, hsa-mir-34b, hsa-mir-451a, hsa-mir-193b, hsa-mir-885, hsa-mir-3690-1, hsa-mir-3935, hsa-mir-4538, hsa-mir-4701, hsa-mir-451b, hsa-mir-3690-2
Differentially expression type microRNA name Mean ratio Up-regulated hsa-miR-193b 2.1165 hsa-miR-34a 3.1282 hsa-miR-100 2.3189 hsa-miR-4485 2.6155 Down-regulated hsa-miR-3690 0.4276 hsa-miR-124 0.3538 hsa-miR-183 0.3946 hsa-miR-3935 0.3999 hsa-miR-451 0.4126 hsa-miR-4538 0.3603 hsa-miR-4701 0.4249 Figure 1 Hierarchical clustering analysis between 5 SALS patients and 5 healthy controls based on differentially expressed miRNAs.
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Differentially expression type microRNA name Mean ratio Up-regulated hsa-miR-193b 2.1165 hsa-miR-34a 3.1282 hsa-miR-100 2.3189 hsa-miR-4485 2.6155 Down-regulated hsa-miR-3690 0.4276 hsa-miR-124 0.3538 hsa-miR-183 0.3946 hsa-miR-3935 0.3999 hsa-miR-451 0.4126 hsa-miR-4538 0.3603 hsa-miR-4701 0.4249 Figure 1 Hierarchical clustering analysis between 5 SALS patients and 5 healthy controls based on differentially expressed miRNAs.
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Four miRNAs, including hsa-miR-34a, hsa-miR-100, hsa-miR-193b, hsa-miR-4485, with significantly higher expression levels were identified in the SALS group compared with those in the healthy control group (mean ratio = 2.11−3.12, p < 0.05, Table 2, Figure 1).
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Other miRNAs from this paper: hsa-mir-1973
Moreover, they reported that hsa-miR-1973 and hsa-miR-4485 are upregulated in senescent endothelial cells and propose that these miRs are derived from the ASncmtRNA-2 stem by Dicer processing [50].
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Transfection of hsa-miR-4485-3p results in downregulation of survivin and N-cadherin levels in MDA-MB-231 cells (Fitzpatrick and Briones, unpublished results).
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Indeed, we found that following ASK, MDA-MB-231 (human breast carcinoma) cells with ASO-1537S [6] for 24 h, hsa-miR-1973 and hsa-miR-4485 are overexpressed about 7-10 times compared to control cells (M. Briones and C. Fitzpatrick, unpublished results).
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Although murine homologues of hsa-miR-1973 and hsa-miR-4485 cannot be currently found in miR databases, the corresponding regions on the mASncmtRNAs display sequence identities of 100% to human for miR-1973, 93% for miR-4485-5p and 90% for miR-4485-3p, suggesting that these segments on the double-stranded region of the ASncmtRNAs could give rise to murine homologues of the corresponding miRs.
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Other miRNAs from this paper: hsa-mir-93, hsa-mir-34a, hsa-mir-217, hsa-mir-218-1, hsa-mir-218-2, hsa-mir-200b, hsa-mir-125b-1, hsa-mir-132, hsa-mir-138-2, hsa-mir-125b-2, hsa-mir-138-1, hsa-mir-146a, hsa-mir-200c, hsa-mir-155, hsa-mir-200a, hsa-mir-34b, hsa-mir-34c, hsa-mir-146b, hsa-mir-513a-1, hsa-mir-513a-2, hsa-mir-582, hsa-mir-513b, hsa-mir-513c
We found that IFN-γ and TNF-α resulted in up-regulation of miR-155–5p, miR-4485–3p, miR-218–5p, and miR-146a–5p and down-regulation of miR-582–5p, miR-582–3p, miR-93–5p, miR-217 and miR-125b–5p (supplemental Tables S1 and S2).
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Other miRNAs from this paper: hsa-mir-199a-1, hsa-mir-139, hsa-mir-183, hsa-mir-199a-2, hsa-mir-125b-1, hsa-mir-125b-2, hsa-mir-150, hsa-mir-328, hsa-mir-483, hsa-mir-494, hsa-mir-572, hsa-mir-574, hsa-mir-638, hsa-mir-762, hsa-mir-885, hsa-mir-940, hsa-mir-1225, hsa-mir-1238, hsa-mir-1202, hsa-mir-1207, hsa-mir-1275, hsa-mir-1915, hsa-mir-1973, hsa-mir-3162, hsa-mir-3196, hsa-mir-4299, hsa-mir-4284, hsa-mir-3679, hsa-mir-3940, hsa-mir-4516, hsa-mir-4530, hsa-mir-4649, hsa-mir-4728, hsa-mir-4739, hsa-mir-371b, hsa-mir-4787, hsa-mir-5787, hsa-mir-6069, hsa-mir-6090
Nineteen of the downregulated miRNAs in chronic patients were found to be associated with carcinogenesis in various organs and tissues, such as miR-1207 [40], miR-3162-5p [41, 42], miR-3196 [43, 44], miR-371b-5p [45], miR-574-5p [46, 47], miR-1225-5p [48], miR-4485 [49], miR-572 [50], miR-4299 [51], miR-3679-5p [52], miR-3940-5p [53], miR-638 [54, 55], miR-1202 [56], miR-5787 [57], miR-1973 [58], miR-4532 [59], miR-1275 [60], miR-4728-5p [61], and miR-1915-3p [62].
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Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-21, hsa-mir-23a, hsa-mir-25, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-107, hsa-mir-196a-1, hsa-mir-10a, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-196a-2, hsa-mir-181a-1, hsa-mir-221, hsa-let-7g, hsa-let-7i, hsa-mir-128-1, hsa-mir-140, hsa-mir-145, hsa-mir-185, hsa-mir-320a, hsa-mir-181b-2, hsa-mir-128-2, hsa-mir-340, hsa-mir-330, hsa-mir-423, hsa-mir-452, hsa-mir-181d, hsa-mir-629, hsa-mir-744, hsa-mir-1307, hsa-mir-103b-1, hsa-mir-103b-2, hsa-mir-4463, hsa-mir-4484
The analysis showed that only four miRNAs: hsa-miR-4461, hsa-miR-4463, hsa-miR-4484 and hsa-miR-4485 aligned to mitochondrial genome at positions (10690–10712), (13050–13068), (5749–5766) and (2562–2582) corresponding to ND4L, ND5, L-ORF and 16S rRNA genes respectively.
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Other miRNAs from this paper: hsa-mir-16-1, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-21, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-27a, hsa-mir-101-1, hsa-mir-16-2, hsa-mir-196a-1, hsa-mir-199a-1, hsa-mir-139, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-196a-2, hsa-mir-199a-2, hsa-mir-203a, hsa-mir-181a-1, hsa-mir-217, hsa-mir-15b, hsa-mir-27b, hsa-mir-122, hsa-mir-146a, hsa-mir-195, hsa-mir-181b-2, hsa-mir-101-2, hsa-mir-296, hsa-mir-26a-2, hsa-mir-362, hsa-mir-365a, hsa-mir-365b, hsa-mir-338, hsa-mir-335, hsa-mir-424, hsa-mir-486-1, hsa-mir-497, hsa-mir-181d, hsa-mir-500a, hsa-mir-551b, hsa-mir-577, hsa-mir-590, hsa-mir-642a, hsa-mir-877, hsa-mir-944, hsa-mir-1293, hsa-mir-1250, hsa-mir-1255a, hsa-mir-1277, hsa-mir-2116, hsa-mir-2277, hsa-mir-2682, hsa-mir-3117, hsa-mir-500b, hsa-mir-3622a, hsa-mir-3654, hsa-mir-3660, hsa-mir-3674, hsa-mir-3679, hsa-mir-3910-1, hsa-mir-3910-2, hsa-mir-4426, hsa-mir-4448, hsa-mir-4454, hsa-mir-4488, hsa-mir-4501, hsa-mir-4508, hsa-mir-1269b, hsa-mir-4687, hsa-mir-203b, hsa-mir-486-2
90 Down 3.84E-18 hsa-miR-4448 2.45 Up 1.66E-04 hsa-miR-1250 −5.71 Down 2.05E-169 hsa-miR-4426 2.23 Up 3.53E-05 hsa-miR-139-5p −5.46 Down 3.71E-25 hsa-miR-720 2.08 Up 1.21E-05 hsa-miR-335-5p −5.26 Down 2.00E-41 hsa-miR-4485 1.71 Up 6.14E-08 hsa-miR-362-3p −5.01 Down 3.36E-10 hsa-miR-877-5p 1.68 Up 1.92E-82 hsa-miR-1255a −4.92 Down 1.25E-62 hsa-miR-3679-5p 1.45 Up 5.53E-04 hsa-miR-3622a-5p −4.83 Down 4.30E-09 hsa-miR-21-3p 1.40 Up 7.87E-13 hsa-miR-1293 −4.67 Down 2.87E-08 hsa-miR-2116-3p −4.64 Down 3.67E-14 hsa-miR-365a-3p −4.
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