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2 publications mentioning egr-mir-71

Open access articles that are associated with the species Echinococcus granulosus and mention the gene name mir-71. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 33
The top five most abundant miRNAs expressed in Echinococcus samples are shown in Figure  4. Interestingly, two miRNAs, miR-71 and let-7, were the most abundantly expressed miRNAs in all the analyzed samples, accounting for about 50% of the total miRNA expression in each sample, suggesting that these miRNAs are essential for Echinococcus survival in the intermediate host. [score:7]
High expression of miR-71 was also observed across platyhelminths such as the cestodes Taenia multiceps [58] and Taenia saginata [59] and the trematode S. japonicum [43, 60], having this miRNA the highest number of predicted targets in S. mansoni [61]. [score:5]
Expression levels of highly expressed miRNAs (miR-71, miR-9, let-7 and miR-4989) were further validated by RT-qPCR in CWG7 and PSG7 samples (Additional file 4). [score:5]
In Echinococcus, highly expressed miRNAs that are absent from vertebrate hosts, such as miR-71, miR-4989 (miR-277 family) and bantam, or that are divergent from host homolog miRNAs (Figure  7), for example let-7, could be evaluated as candidate targets for diagnosis or intervention strategies. [score:3]
In coincidence with our results, miR-71, let-7 and miR-1 were recently reported among the top 5 most expressed miRNAs in E. granulosus s. s. G1 protoscoleces and cysts [37]. [score:3]
Relative quantification between PSG7 and CWG7 was performed using the 2 [-∆∆CT] method [33] using miR-71-5p as endogenous control since it was found to be consistently expressed in both sample types. [score:3]
However, miR-71, a bilaterian miRNA absent in vertebrates, is known to be involved in C. elegans lifespan regulation [62] and stress responses [63]. [score:2]
In particular, miR-71 and let-7 were among the most abundant miRNAs in all samples analyzed. [score:1]
Additional file 4: Expression level of selected miRNAs measured by RT-qPCR relative to miR-71 in each Echinococcus canadensis G7 stage. [score:1]
This file contains a supplemental figure that shows the miRNA expression profile of fifteen randomly selected miRNAs relative to miR-71 in CWG7 and PSG7 samples measured by RT-qPCR. [score:1]
So far, there is no information about the function of miR-71 and let-7 in Echinococcus. [score:1]
Since the metacestode lives long term in the hostile host environment, probably producing molecules to modulate the host immune response [51] it would be interesting to determine whether miR-71 is involved in responding to the stress induced by the immune system of the host and/or the longevity of the parasite. [score:1]
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[+] score: 1
In the present study, besides two published miRNA clusters, miR-71/2b/2d and miR-277/4988 [25], we identified two additional miRNA clusters located in closed loci (EG_S00041: 46,144-53,961 and pathogen_EMU_scaffold_007768: 2,420,386-2,428,006) in the genomes of both E. granulosus and E. multilocularis (Figure 2a). [score:1]
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