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3 publications mentioning hsa-mir-6069

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-6069. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 39
To understand the role of immunological and genetic factors involved in the transition of brucellosis into chronic infection, target pathway prediction of miR-1238-3p, miR-494, miR-6069, and miR-139-3p was performed according to KEGG function annotations, which increased miRNA (miR-1238-3p) of target genes involved in immunologically effective pathways as shown in Figure 2. miRNAs (miR-494, miR-6069, and miR-139-3p) that were downregulated in the chronic group were considered common. [score:7]
To understand the role of immunological and genetic factors involved in the transition of brucellosis into chronic infection, target pathway prediction of miR-1238-3p, miR-494, miR-6069, and miR-139-3p was performed according to KEGG function annotations, which increased miRNA (miR-1238-3p) of target genes involved in immunologically effective pathways as shown in Figure 2. miRNAs (miR-494, miR-6069, and miR-139-3p) that were downregulated in the chronic group were considered common. [score:7]
miR-1238-3p was upregulated, while miR-494, miR-6069, and miR-139-3p were downregulated in the chronic group compared with the active group. [score:6]
In the present study, we uniquely determined that reduced expression of miR-139-3p, miR-6069, and miR-494 and induced expression of miR-1238-3p were significantly associated with chronic brucellosis. [score:5]
The third downregulated miRNA was miR-6069. [score:4]
The predicted number of target genes is present in Figure 4.183 genes (3%) were regulated mutually by miR-494, miR-139-3p, and miR-6069. [score:4]
Although the function of this miRNA remains unknown in biological processes, in the current study we uniquely determined that reduced expression of miR-6069 may have functions in regulation of actin cytoskeleton, MAPK signaling pathway, endocytosis, cytokine-cytokine receptor interaction, chemokine signaling pathway, JAK-STAT signaling pathway, T cell receptor signaling pathway, leukocyte transendothelial migration Toll-like receptor signaling pathway, Fc γR -mediated phagocytosis, and bacterial invasion of epithelial cells signaling pathways in chronic brucellosis. [score:4]
Mutual KEGG pathway analysis of miR-494, miR-139-3p, and miR-6069 revealed that pathways related to these miRNAs in brucellosis have biological significance associated with the conversion of chronicity, including endocytosis, regulation of actin cytoskeleton, MAPK signaling pathway, cytokine-cytokine receptor interaction, and chemokine signaling pathways. [score:2]
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2
[+] score: 11
In our recent study, we have shown that reduced expression of miR-139-3p, miR-6069 and miR-494 and induced expression of miR-1238-3p were significantly associated with chronic brucellosis [43]. [score:5]
In our previous study, more than 2000 miRNAs were screened in peripheral blood mononuclear cells of patients with acute or chronic brucellosis and we determined that while the expression level of miR-1238-3p was increased, miR-494, miR-6069 and miR-139-3p were decreased in the chronic group in comparison to the acute infection group [43]. [score:3]
Altered expressions of miR-1238-3p, miR-494, miR-6069 and miR-139-3p in the formation of Chronic Brucellosis. [score:3]
[1 to 20 of 3 sentences]
3
[+] score: 5
Altered expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the formation of chronic brucellosis. [score:3]
In one of our previous studies, more than 2,000 miRNAs were screened in peripheral blood mononuclear cells of patients with acute or chronic brucellosis, and we determined that while the expression level of miR-1238-3p increased, miR-494, miR-6069, and miR-139-3p decreased in the chronic group compared to the acute group. [score:2]
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