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4 publications mentioning sma-mir-124a

Open access articles that are associated with the species Schistosoma mansoni and mention the gene name mir-124a. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 22
Other miRNAs from this paper: sma-let-7, sma-mir-124b
Since the neuropil is comprised of neural projections (axons and dendrites) these data suggest that sma-miR-124a-3p may have functions to regulate its target mRNAs outside the cell bodies. [score:4]
Consistent with the localization of miR-124a in C. elegans, we detected the expression of sma-miR-124a-3p in the schistosome cephalic ganglia and in the nerve chords by WISH (Fig 5B). [score:3]
To further assess the feasibility to detect Schistosome miRNAs using LNA probes we also examined sma-miR-124a-3p, whose closely related C. elegans homolog (miR-124a) is expressed in the nervous system [80]. [score:3]
We observed that sma-miR-124a-3p and pc2 were co-expressed in cell bodies that comprise both the cephalic ganglia and the nerve chords (Supplementary S5A Fig). [score:3]
Fluorescence in situ hybridization (FISH) in adult male worms using a Locked Nucleic Acid (LNA) probe to detect sma-miR-124a-3p (instead of antisense mRNA probes) and prohormone convertase 2 (pc2), that is expressed in the large number of cells in the schistosome nervous system. [score:3]
Interestingly, we detected sma-miR-124a-3p not just in pc2 [+] cell bodies but also broadly throughout the neuropil of the cephalic ganglia (Supplementary S5B Fig). [score:1]
Given our success in detecting sma-miR-124a-3p, we set out to determine the localization of sma-miR-4989. [score:1]
Fluorescence in situ hybridization of sma-miR-124. [score:1]
Whole mount in situ hybridisation for (A) cathepsin B, (B) sma-miR-124a-3p (124a), and (C) sma-miR-4989. [score:1]
0005559.g005 Fig 5Whole mount in situ hybridisation for (A) cathepsin B, (B) sma-miR-124a-3p (124a), and (C) sma-miR-4989. [score:1]
S5 FigFluorescence in situ hybridization of sma-miR-124. [score:1]
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2
[+] score: 6
Using bioinformatics (see methods) we were able to find only one further miRNA candidate in S. mansoni, mir-124, that is also conserved in S. japonicum. [score:1]
The uncertain mir-287 candidate clusters together with mir-124 in insect genomes. [score:1]
However, the schistosome sequences are more related to the other bilaterian mir-124 homologs than to those of S. mediterranea. [score:1]
For mir-124 and mir-749 the sequences share a common consensus structure. [score:1]
Of those 29 miRNAs, we found mir-124 only. [score:1]
We found an uncertain mir-287 candidate in S. mansoni, however, on a different scaffold than mir-124. [score:1]
[1 to 20 of 6 sentences]
3
[+] score: 1
Amongst these, we show that the deeply-conserved mir-124 locus produces microRNAs from both genomic strands in S. mansoni (Supplementary Files S2). [score:1]
[1 to 20 of 1 sentences]
4
[+] score: 1
Other miRNAs from this paper: hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, sma-mir-124b
MIR124 stands for human microRNA 124. [score:1]
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