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miRBase |
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![]() 4 publications mentioning sma-mir-2dOpen access articles that are associated with the species Schistosoma mansoni and mention the gene name mir-2d. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary. |
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Other miRNAs from this paper: sma-let-7, sma-mir-71a, sma-bantam, sma-mir-124a, sma-mir-2a, sma-mir-2b, sma-mir-2c, sma-mir-2e, sma-mir-31, sma-mir-36a, sma-mir-61, sma-mir-71b, sma-mir-36b, sma-mir-8437, sma-mir-281, sma-mir-8447, sma-mir-8451, sma-mir-124b, sma-mir-1a, sma-mir-755, sma-mir-1b, sma-mir-2162, sma-mir-2f
Duplication of a gene into an autosome has been recently proposed as a way to escape such conflict (reviewed in [36]), and the mir-71/mir-2 cluster duplication appears to be an example of this.
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Also, five of our female-biased microRNAs also showed a female bias in their work (mir-71b, mir-2c, mir-2d, bantam and mir-31).
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The mir-71/mir-2 microRNA cluster is highly conserved in invertebrates, and it has been shown that this cluster is duplicated in Platyhelminthes [25], [28].
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This has led some authors to postulate that the mir-71/mir-2 clusters may be involved in sexual maturation in Schistosoma [25].
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Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-10a, hsa-mir-10b, hsa-let-7g, hsa-let-7i, sja-let-7, sja-mir-71a, sja-bantam, sma-let-7, sma-mir-71a, sma-bantam, sja-mir-2a, sja-mir-2b, sja-mir-10, sja-mir-71b, sja-mir-2c, sja-mir-2d, sja-mir-2e, sma-mir-10, sma-mir-2a, sma-mir-2b, sma-mir-2c, sma-mir-2e, sma-mir-71b, sma-mir-2f
Five out of the 13 known miRNAs coming from one family named as sja-miR-2, including family members from miR-2a to miR-2e.
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Blue: the largest family members of miR-2. Two conserved miRNAs named as bantam and let-7 were found in both S. japonicum and S. mansoni miRNAs.
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Blue: the largest family members of miR-2. Two conserved miRNAs named as bantam and let-7 were found in both S. japonicum and S. mansoni miRNAs.
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Besides the miR-2 family, another two miRNAs, miR-71 and miR-71b-5p, were also found from one family, which is located on two different scaffolds named as SJC_S000054 and SJC_S000102.
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Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-125b-1, hsa-mir-125b-2, hsa-mir-190a, hsa-mir-1-1, hsa-mir-450a-1, hsa-mir-450a-2, hsa-mir-598, hsa-mir-450b, hsa-mir-190b, sja-let-7, sja-mir-71a, sja-bantam, sja-mir-125b, sma-let-7, sma-mir-71a, sma-bantam, sma-mir-125b, sja-mir-1, sja-mir-2a, sja-mir-2b, sja-mir-71b, sja-mir-190, sja-mir-2c, sja-mir-2d, sja-mir-2e, sma-mir-190, sma-mir-2a, sma-mir-2b, sma-mir-2c, sma-mir-2e, sma-mir-71b, sma-mir-281, sma-mir-8451, sma-mir-1a, sma-mir-1b, sma-mir-2f
Moreover, the four novel miRNAs transcribed principally in male adults, including one miRNA (sha-miR-new_46) encoded on the same scaffold as the mir-71/mir-2 cluster (KL250488.1) with a CPM more than 20-times higher than that in the library derived from adult female worms, suggest male-specific roles for these miRNAs in gene regulation.
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These results are consistent with reports of a mir-71/mir-2 cluster duplication in S. mansoni [10, 11] and S. japonicum [14, 34] on the female-sex (W) chromosome and on one autosome (chromosome 5), and further support roles in sex-specific traits, sexual differentiation, pairing of adult worms and reproductive processes in schistosomes.
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Other miRNAs from this paper: sja-let-7, sja-mir-71a, sja-bantam, sja-mir-125a, sja-mir-125b, sma-let-7, sma-mir-71a, sma-bantam, sma-mir-125a, sma-mir-125b, sja-mir-1, sja-mir-2a, sja-mir-2b, sja-mir-36, sja-mir-71b, sja-mir-2c, sja-mir-2d, sja-mir-2e, sma-mir-2a, sma-mir-2b, sma-mir-2c, sma-mir-2e, sma-mir-36a, sma-mir-71b, sma-mir-125c, sma-mir-36b, sma-mir-1a, sma-mir-1b, sma-mir-2f
We observed 2 miRNAs (mir-2 and mir-71) expressed in both life cycle stages tested, 7 in adult worms only (mir-4, mir-6, mir-9, mir-32, mir-125, mir-3, mir-5) and 5 in schistosomula only (mir-20, mir-18, mir-22, mir-26, Bantam).
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