| 1 |
[+]
score:
11
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-18a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-21, hsa-mir-23a, hsa-mir-31, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-96, hsa-mir-98, hsa-mir-99a, hsa-mir-106a, mmu-let-7g, mmu-let-7i, mmu-mir-23b, mmu-mir-99a, mmu-mir-127, mmu-mir-128-1, mmu-mir-136, mmu-mir-142a, mmu-mir-145a, mmu-mir-10b, mmu-mir-182, mmu-mir-183, mmu-mir-187, mmu-mir-193a, mmu-mir-195a, mmu-mir-200b, mmu-mir-206, mmu-mir-143, hsa-mir-139, hsa-mir-10b, hsa-mir-182, hsa-mir-183, hsa-mir-187, hsa-mir-210, hsa-mir-216a, hsa-mir-217, hsa-mir-219a-1, hsa-mir-221, hsa-mir-222, hsa-mir-224, hsa-mir-200b, mmu-mir-302a, mmu-let-7d, mmu-mir-106a, hsa-let-7g, hsa-let-7i, hsa-mir-23b, hsa-mir-128-1, hsa-mir-142, hsa-mir-143, hsa-mir-145, hsa-mir-127, hsa-mir-136, hsa-mir-193a, hsa-mir-195, hsa-mir-206, mmu-mir-19b-2, mmu-mir-200a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-18a, mmu-mir-21a, mmu-mir-23a, mmu-mir-31, mmu-mir-92a-2, mmu-mir-96, mmu-mir-98, hsa-mir-200c, mmu-mir-17, mmu-mir-139, mmu-mir-200c, mmu-mir-210, mmu-mir-216a, mmu-mir-219a-1, mmu-mir-221, mmu-mir-222, mmu-mir-224, mmu-mir-19b-1, mmu-mir-92a-1, mmu-mir-128-2, hsa-mir-128-2, mmu-mir-217, hsa-mir-200a, hsa-mir-302a, hsa-mir-219a-2, mmu-mir-219a-2, hsa-mir-363, mmu-mir-363, hsa-mir-302b, hsa-mir-302c, hsa-mir-302d, hsa-mir-371a, hsa-mir-18b, hsa-mir-20b, hsa-mir-452, mmu-mir-452, ssc-mir-106a, ssc-mir-145, ssc-mir-216-1, ssc-mir-217-1, ssc-mir-224, ssc-mir-23a, ssc-mir-183, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-128-1, ssc-mir-136, ssc-mir-139, ssc-mir-18a, ssc-mir-21, hsa-mir-146b, hsa-mir-493, hsa-mir-495, hsa-mir-497, hsa-mir-505, mmu-mir-20b, hsa-mir-92b, mmu-mir-302b, mmu-mir-302c, mmu-mir-302d, hsa-mir-671, mmu-mir-216b, mmu-mir-671, mmu-mir-497a, mmu-mir-495, mmu-mir-146b, mmu-mir-708, mmu-mir-505, mmu-mir-18b, mmu-mir-493, mmu-mir-92b, hsa-mir-708, hsa-mir-216b, hsa-mir-935, hsa-mir-302e, hsa-mir-302f, ssc-mir-17, ssc-mir-210, ssc-mir-221, mmu-mir-1839, ssc-mir-146b, ssc-mir-206, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-128-2, ssc-mir-143, ssc-mir-10b, ssc-mir-23b, ssc-mir-193a, ssc-mir-99a, ssc-mir-98, ssc-mir-92a-2, ssc-mir-92a-1, ssc-mir-92b, ssc-mir-142, ssc-mir-497, ssc-mir-195, ssc-mir-127, ssc-mir-222, ssc-mir-708, ssc-mir-935, ssc-mir-19b-2, ssc-mir-19b-1, ssc-mir-1839, ssc-mir-505, ssc-mir-363-1, hsa-mir-219b, hsa-mir-371b, ssc-let-7a-2, ssc-mir-18b, ssc-mir-187, ssc-mir-218b, ssc-mir-219a, mmu-mir-195b, mmu-mir-145b, mmu-mir-21b, mmu-let-7j, mmu-mir-21c, ssc-let-7d, ssc-let-7f-2, ssc-mir-20b-1, ssc-mir-20b-2, ssc-mir-31, ssc-mir-182, ssc-mir-217-2, ssc-mir-363-2, ssc-mir-452, ssc-mir-493, ssc-mir-671, mmu-let-7k, ssc-mir-7138, mmu-mir-219b, mmu-mir-216c, mmu-mir-142b, mmu-mir-497b, mmu-mir-935, ssc-mir-9843, ssc-mir-371, ssc-mir-219b, ssc-mir-96, ssc-mir-200b
Ssc-miR-216 and ssc-miR-217 were also located in the same genome loci in chromosome 3. Overexpression of has-miR-216a/217 activates the PI3K/Akt and TGF-β signaling pathways by targeting PTEN and SMAD7 in human hepatocellular carcinoma cells [54].
[score:5]
Additionally, ssc-miR-216, ssc-miR-217, ssc-miR-142-5p, ssc-miR-96-5p, ssc-miR-182 and ssc-miR-183 have higher expression levels in mpiPSCs than that in hpiPSCs (Fig 3A).
[score:3]
Ssc-miR-216 was also highly expressed in mpiPSCs.
[score:3]
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| 2 |
[+]
score:
7
Other miRNAs from this paper: ssc-mir-122, ssc-mir-148a, ssc-mir-15b, ssc-mir-184, ssc-mir-216-1, ssc-mir-24-1, ssc-mir-140, ssc-mir-27a, ssc-mir-21, ssc-mir-30c-2, ssc-mir-210, ssc-mir-221, ssc-mir-101-1, ssc-mir-101-2, ssc-mir-133a-1, ssc-mir-30a, ssc-mir-143, ssc-mir-10a, ssc-mir-10b, ssc-mir-27b, ssc-mir-24-2, ssc-mir-193a, ssc-mir-192, ssc-mir-100, ssc-mir-222, ssc-mir-574, ssc-mir-335, ssc-mir-129a, ssc-mir-133a-2, ssc-mir-4332, ssc-mir-652, ssc-mir-146a, ssc-mir-30c-1, ssc-mir-451, ssc-mir-129b, ssc-mir-1343, ssc-mir-582
Eight DEMs, 4 down-regulated (miR-146a, miR-222, miR-574 and miR-652) and 4 up-regulated (miR-100, miR-133a, miR-216 and miR-582-5p), were randomly chosen for validation using RT-qPCR.
[score:7]
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| 3 |
[+]
score:
5
Other miRNAs from this paper: hsa-mir-17, hsa-mir-18a, hsa-mir-19b-2, hsa-mir-22, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-29a, hsa-mir-92a-2, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-106a, hsa-mir-7-1, hsa-mir-7-2, hsa-mir-7-3, hsa-mir-216a, hsa-mir-217, hsa-mir-221, hsa-mir-222, hsa-let-7i, hsa-mir-27b, hsa-mir-135a-1, hsa-mir-135a-2, hsa-mir-142, hsa-mir-191, hsa-mir-29c, hsa-mir-135b, hsa-mir-18b, ssc-mir-106a, ssc-mir-216-1, ssc-mir-217-1, ssc-mir-24-1, ssc-mir-29b-1, ssc-mir-7-2, ssc-let-7i, ssc-mir-103-1, ssc-mir-18a, ssc-mir-29c, hsa-mir-455, hsa-mir-216b, hsa-mir-103b-1, hsa-mir-103b-2, ssc-mir-17, ssc-mir-221, ssc-mir-29a, ssc-mir-191, ssc-mir-103-2, ssc-mir-27b, ssc-mir-24-2, ssc-mir-92a-2, ssc-mir-142, ssc-mir-222, ssc-mir-19b-2, ssc-mir-455, ssc-mir-22, ssc-mir-18b, ssc-mir-7-1, ssc-mir-29b-2, ssc-mir-217-2
Therefore, miRNAs up-regulated in F50 cerebellum (e. g. miR-135a, miR-135b and miR-7, see Figure 2) and F100 cerebellum (e. g. miR-216a and miR-216) make promising candidates for developmental switches in the cerebellum.
[score:5]
[1 to 20 of 1 sentences]
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| 4 |
[+]
score:
1
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-27a, hsa-mir-196a-1, hsa-mir-148a, hsa-mir-139, hsa-mir-34a, hsa-mir-181c, hsa-mir-196a-2, hsa-mir-216a, hsa-mir-224, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-152, hsa-mir-206, hsa-mir-1-1, hsa-mir-34c, hsa-mir-376a-1, hsa-mir-323a, hsa-mir-148b, hsa-mir-339, hsa-mir-133b, hsa-mir-196b, hsa-mir-423, ssc-mir-148a, ssc-mir-19a, ssc-mir-216-1, ssc-mir-224, ssc-mir-323, ssc-mir-181c, ssc-mir-27a, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-139, ssc-mir-196a-2, hsa-mir-376a-2, hsa-mir-1296, hsa-mir-885, hsa-mir-216b, ssc-mir-34a, ssc-mir-133a-1, ssc-mir-1, ssc-mir-206, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-133b, ssc-mir-423, ssc-mir-152, ssc-mir-148b, ssc-mir-885, ssc-mir-34c-1, ssc-mir-196b-1, ssc-mir-339-1, ssc-mir-19b-2, ssc-mir-19b-1, hsa-mir-323b, ssc-mir-376a, ssc-mir-133a-2, ssc-mir-4334, ssc-mir-1296, ssc-let-7a-2, ssc-mir-2320, ssc-let-7d, ssc-let-7f-2, ssc-mir-34c-2, ssc-mir-196a-1, ssc-mir-196b-2, ssc-mir-339-2
Each poly-miRTS was either found in several alleles (e. g. miR-224 site in SLA-3), or in a single allele (e. g. miR-216 site in SLA-3: gb_EU432082.1 allele) (e. g. SLA-3: Figure 2).
[score:1]
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