miRBase
|
|
miRBase |
|
|
||
![](javascript:TINY.box.show( {html:'<img style="padding:20px;" width=460 src="/images/wordcloud/00/22/95/MI0022958.png">', width:500, height:500, mask:true, opacity:5, close:true} ))
sort by
2 publications mentioning hsa-mir-7107Open access articles that are associated with the species Homo sapiens and mention the gene name mir-7107. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary. |
|
| 1 |
Other miRNAs from this paper: hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-22, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-26a-1, hsa-mir-16-2, hsa-mir-183, hsa-mir-210, hsa-mir-146a, hsa-mir-185, hsa-mir-155, hsa-mir-200a, hsa-mir-26a-2, hsa-mir-328, hsa-mir-181d, hsa-mir-504, hsa-mir-320d-1, hsa-mir-320d-2, hsa-mir-3940, hsa-mir-4487, hsa-mir-4654, hsa-mir-4707, hsa-mir-4740, hsa-mir-6821, hsa-mir-6824, hsa-mir-6865, hsa-mir-6878, hsa-mir-8074
Estrogen inhibitor (Letrozole) down-regulates (a) miR-26a-5p, (b) miR-146a-5p, (c) miR-328-5p, (d) miR-4654 and up-regulated (e) miR-7107-5p in EVs cargo of human synovial fibroblast cells.
[score:9]
Some of the EV miRNAs (miR-181d-3p, miR-155-3p, miR-185-5p, miR-3940-3p, miR-4532, miR-7107-5p miR-504-3p, miR-320d, miR-19b-3p and miR-22-3p) up-regulated in female OA synovial fluid were down-regulated in response to estrogen treatment in human and mouse cells 51– 54.
[score:7]
We also found that miR-185-5p and miR-7107-5p significantly (p < 0.05) down regulated expression of CREB -binding protein whereas miR-181d-3p did not show significant change in expression of CREB -binding protein (Fig. 5).
[score:6]
MicroRNA-7107-5p mimic significantly (p < 0.01) down-regulated expression of estrogen receptor-α and estrogen receptor-β, but produced no change in aromatase cytochrome P450 (CYP19A1) (Fig. 5).
[score:5]
Further detailed analysis showed that 6 miRNAs (miR-181d-3p, miR-3940-3p, miR-155-3p, miR-4532, miR-185-5p, miR-7107-5p) target 9 genes of the ovarian steroidogenesis pathway and the same number of miRNAs (miR-4532, miR-181d-3p, miR-185-5p miR-6865-3p, miR-4459, miR-7107-5p) target 14 genes of the estrogen signaling pathway.
[score:5]
The miR-185-5p and miR-7107-5p mimics did not show any changes in n-COR and TIF2 gene expressions (Fig. 5).
[score:3]
We further confirmed that some of these miRNAs (181d-3p, miR-185-5p, miR-7107-5p) target female estrogen signaling pathway genes.
[score:3]
Our results show that aromatase inhibitor treatment decrease content of miR-26a-5p, miR-146a-5p, miR-328-5p, miR-4654, and increased miR-7107-5p in EVs cargo.
[score:3]
MiRNAs (181d-3p, miR-185-5p, miR-7107-5p) regulates (a) ER-α (estrogen receptor- α), (b) ER-β estrogen receptor- β), (c) CYP19 (aromatase cytochrome P450), (d) CREB -binding protein, (e) nCOR (Nuclear Receptor Co-repressor) and (f) TIF2 (Transcriptional Intermediary Factor 2) in human articular chondrocytes.
[score:2]
To determine whether OA related miRNAs are involved in estrogen -mediated gene regulation of articular chondrocytes, the cells were treated with miRNA mimics (181d-3p, miR-185-5p, miR-7107-5p) for 24 h and estrogen signaling pathway genes were analyzed.
[score:2]
Scrambled (Negative control) miRNA and miRNA mimics for miR-181d-3p, miR-185-5p and miR-7107-5p were purchased from QIAGEN.
[score:1]
We did not find any significant changes in content of miR-181d-3p and miR-7107-5p in EVs cargo.
[score:1]
[1 to 20 of 12 sentences]
|
| 2 |
Other miRNAs from this paper: hsa-mir-451a, mmu-mir-451a, hsa-mir-1224, mmu-mir-1224, mmu-mir-702, mmu-mir-877, hsa-mir-877, hsa-mir-1178, hsa-mir-1236, hsa-mir-1238, hsa-mir-548o, mmu-mir-1983, mmu-mir-3062, mmu-mir-3064, mmu-mir-3087, mmu-mir-3102, hsa-mir-4641, hsa-mir-451b, hsa-mir-3064, hsa-mir-4745, mmu-mir-5129, mmu-mir-5132, mmu-mir-451b, mmu-mir-7661
We also downgraded 4 mirtrons in mirBase which failed the 50 total reads criteria (hsa-mir-1178, hsa-mir-7107, hsa-mir-1238), or lacked both star reads and Ago-IP reads (hsa-mir-4641).
[score:1]
[1 to 20 of 1 sentences]
|