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12 publications mentioning oar-mir-143

Open access articles that are associated with the species Ovis aries and mention the gene name mir-143. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 59
In these miRNAs, miRNA-143 was upregulated in hair follicles and is differentially expressed in small and large waves. [score:6]
The upregulation of miR-143 in these malignancies inhibits cell growth, which in turn indicates that it participates in cell differentiation, proliferation, apoptosis, and metabolism [24– 28]. [score:6]
Combined with the study on the differential expression of miRNA-143 in large, medium, and small wave patterns, we inferred that miRNA -143 regulates Hu sheep hair follicle development. [score:5]
miRNA-143 has been reported to be downregulated in gastric, lung, cervical, and bladder cancer. [score:4]
In the present study, miRNA-143 was one of the upregulated miRNAs in Hu sheep hair follicular tissues. [score:4]
In the present study, we found that LIM-only protein 4 (LMO4) was the direct target gene of miRNA-143 and NW_004080184.1_632. [score:4]
The expression pattern of miR-143, miR-10a, miR-199p-3a, let-7c, let-7i, NW_004080189.1_7961, NW_004080184.1_6535, NW_004080184.1_6326, NW_004080165.1_8572, NW_004080166.1_9139, NW_004080181.1_3961, NW_004080174.1_726, NW_004080166.1_10417 and NW_004080190.1_13733 showed that they may participate in the formation of hair follicles and different flower pattern. [score:3]
The correlation analysis between these 14 miRNAs expression and histological properties of hair follicle in large, medium and small waves showed that miRNA-143, miRNA-10a, let-7i, NW_004080184.1_6326, NW_004080165.1_8572, NW_004080181.1_3961 and NW_004080190.1_13733 can be considered as the important candidate miRNA to Hu sheep lambskin hair follicle development. [score:3]
The level of expression of miRNA-143 in the large waves was significantly lower than that in the large waves (P<0.01). [score:3]
We preliminarily designated miRNA-143, miRNA-10a, let-7i, NW_004080184.1_6326, NW_004080165.1_8572, NW_004080181.1_3961, and NW_004080190.1_13733 as candidate miRNAs that regulate the development of Hu sheep hair follicles. [score:3]
Additionally, the results showed that the expression level of miRNA-143 in small waves was higher than that in large and medium waves at the same period, and highly significant differences between large and small wave lambskin hair follicles were observed. [score:3]
Our results showed that seven candidate miRNAs, namely, miRNA-143, miRNA-10a, let-7i, NW_004080184.1_6326, NW_004080165.1_8572, NW_004080181.1_3961, and NW_004080190.1_13733, are involved in the development of Hu sheep lambskin hair follicles, which in turn may facilitate in the elucidation of the molecular mechanism underlying its growth and development in Hu sheep lambskin. [score:3]
Seven miRNAs were differentially expressed in different wave patterns, namely, miRNA-143, miRNA-10a, and let-7i, and four novel miRNAs, including NW_004080184.1_6326, NW_004080165.1_8572, NW_004080181.1_3961, and NW_004080190.1_13733. [score:3]
Consequently, we speculated that miRNA-143 regulates sheep hair growth during hair follicle cell development. [score:3]
In addition, in novel miRNAs, a correlation between the expression levels of NW_004080184.1_6326, NW_004080165.1_8572, NW_004080181.1_3961, NW_004080190.1_13733, miRNA-143, miRNA-10a, and let-7i and the diameter of secondary follicles in large and medium waves and the number of secondary follicles in small waves was observed, which coincided with our biopsy results. [score:3]
No studies on the function of miRNA-143 in hair follicles have been conducted, although the results of the present study suggest that it might play an important role in the growth and development of hair follicles. [score:2]
Previous studies have shown that miRNA-143 plays an important role various malignancies [22– 23]. [score:1]
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2
[+] score: 18
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-21, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-26a-1, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-99a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-16-2, hsa-mir-192, hsa-mir-148a, hsa-mir-10b, hsa-mir-181a-2, hsa-mir-181a-1, hsa-mir-215, hsa-mir-223, hsa-mir-224, hsa-mir-200b, hsa-mir-15b, hsa-mir-27b, hsa-mir-125b-1, hsa-mir-141, hsa-mir-143, hsa-mir-152, hsa-mir-125b-2, hsa-mir-126, hsa-mir-146a, hsa-mir-184, hsa-mir-200c, hsa-mir-155, hsa-mir-29c, hsa-mir-200a, hsa-mir-99b, hsa-mir-296, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-378a, hsa-mir-342, hsa-mir-148b, hsa-mir-451a, ssc-mir-125b-2, ssc-mir-148a, ssc-mir-15b, ssc-mir-184, ssc-mir-224, ssc-mir-23a, ssc-mir-24-1, ssc-mir-26a, ssc-mir-29b-1, ssc-let-7f-1, ssc-mir-103-1, ssc-mir-21, ssc-mir-29c, hsa-mir-486-1, hsa-mir-499a, hsa-mir-671, hsa-mir-378d-2, bta-mir-26a-2, bta-mir-29a, bta-let-7f-2, bta-mir-103-1, bta-mir-148a, bta-mir-16b, bta-mir-21, bta-mir-499, bta-mir-99a, bta-mir-125b-1, bta-mir-126, bta-mir-181a-2, bta-mir-27b, bta-mir-31, bta-mir-15b, bta-mir-215, bta-mir-30e, bta-mir-148b, bta-mir-192, bta-mir-200a, bta-mir-200c, bta-mir-23a, bta-mir-29b-2, bta-mir-29c, bta-mir-10b, bta-mir-24-2, bta-mir-30a, bta-mir-200b, bta-let-7a-1, bta-mir-342, bta-let-7f-1, bta-let-7a-2, bta-let-7a-3, bta-mir-103-2, bta-mir-125b-2, bta-mir-15a, bta-mir-99b, hsa-mir-664a, ssc-mir-99b, hsa-mir-103b-1, hsa-mir-103b-2, ssc-mir-15a, ssc-mir-16-2, ssc-mir-16-1, bta-mir-141, bta-mir-143, bta-mir-146a, bta-mir-152, bta-mir-155, bta-mir-16a, bta-mir-184, bta-mir-24-1, bta-mir-223, bta-mir-224, bta-mir-26a-1, bta-mir-296, bta-mir-29d, bta-mir-378-1, bta-mir-451, bta-mir-486, bta-mir-671, bta-mir-29e, bta-mir-29b-1, bta-mir-181a-1, ssc-mir-181a-1, ssc-mir-215, ssc-mir-30a, bta-mir-2318, bta-mir-2339, bta-mir-2430, bta-mir-664a, bta-mir-378-2, ssc-let-7a-1, ssc-mir-378-1, ssc-mir-29a, ssc-mir-30e, ssc-mir-499, ssc-mir-143, ssc-mir-10b, ssc-mir-486-1, ssc-mir-152, ssc-mir-103-2, ssc-mir-181a-2, ssc-mir-27b, ssc-mir-24-2, ssc-mir-99a, ssc-mir-148b, ssc-mir-664, ssc-mir-192, ssc-mir-342, ssc-mir-125b-1, oar-mir-21, oar-mir-29a, oar-mir-125b, oar-mir-181a-1, hsa-mir-378b, hsa-mir-378c, ssc-mir-296, ssc-mir-155, ssc-mir-146a, bta-mir-148c, ssc-mir-126, ssc-mir-378-2, ssc-mir-451, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-451b, hsa-mir-499b, ssc-let-7a-2, ssc-mir-486-2, hsa-mir-664b, hsa-mir-378j, ssc-let-7f-2, ssc-mir-29b-2, ssc-mir-31, ssc-mir-671, bta-mir-378b, bta-mir-378c, hsa-mir-486-2, oar-let-7a, oar-let-7f, oar-mir-103, oar-mir-10b, oar-mir-148a, oar-mir-152, oar-mir-16b, oar-mir-181a-2, oar-mir-200a, oar-mir-200b, oar-mir-200c, oar-mir-23a, oar-mir-26a, oar-mir-29b-1, oar-mir-30a, oar-mir-99a, bta-mir-664b, chi-let-7a, chi-let-7f, chi-mir-103, chi-mir-10b, chi-mir-125b, chi-mir-126, chi-mir-141, chi-mir-143, chi-mir-146a, chi-mir-148a, chi-mir-148b, chi-mir-155, chi-mir-15a, chi-mir-15b, chi-mir-16a, chi-mir-16b, chi-mir-184, chi-mir-192, chi-mir-200a, chi-mir-200b, chi-mir-200c, chi-mir-215, chi-mir-21, chi-mir-223, chi-mir-224, chi-mir-2318, chi-mir-23a, chi-mir-24, chi-mir-26a, chi-mir-27b, chi-mir-296, chi-mir-29a, chi-mir-29b, chi-mir-29c, chi-mir-30a, chi-mir-30e, chi-mir-342, chi-mir-378, chi-mir-451, chi-mir-499, chi-mir-671, chi-mir-99a, chi-mir-99b, bta-mir-378d, ssc-mir-378b, oar-mir-29b-2, ssc-mir-141, ssc-mir-200b, ssc-mir-223, bta-mir-148d
A role for endogenous miRNA-143 in the differentiation of bovine intramuscular fat was demonstrated whereby transfection of fibroblast-like preadipocytes with miRNA-143 antisense inhibitor suppressed differentiation followed by decreased storage of lipid droplets and expression of key adipocytes regulatory genes such as CCAAT/enhancer binding protein-a and fatty acid binding protein-4 while miRNA-143 inhibitor transfection increased cell proliferation (Li et al., 2011a). [score:10]
Ye et al. (2012) examined miRNA expression in the duodenum of E. coli F18-sensitive and -resistant weaned piglets and identified 12 candidate miRNA (ssc-miR-143, ssc-let-7f, ssc-miR-30e, ssc-miR-148a, ssc-miR-148b, ssc-miR-181a, ssc-miR-192, ssc-miR-27b, ssc-miR-15b, ssc-miR-21, ssc-miR-215, and ssc-miR-152) disease markers. [score:5]
Additionally, a number of miRNAs including miR-148a, miR-26a, miR-21-5p, miR-27b, miR-143, bta-miR-30a-5p, let-7a-5p, let-7f, miR-10b, and miR-99a-5p are highly expressed in bovine mammary gland/mammary epithelial cells (Li et al., 2012a, 2014a; Jin et al., 2014a; Le Guillou et al., 2014) suggesting roles in the lactation process and mammary gland functions. [score:3]
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[+] score: 15
For example, miR-29c, the miR-34 family, miR-143, miR-145 and miR-9 are downregulated in NPC, leading to increased expression of their target genes which influence the function and synthesis of extracellular matrix proteins, which in turn affects tumor invasion and metastasis, and activates the TGF-Wnt, IP3 and VEGF signaling pathways [44, 45]. [score:8]
By blasting the 435 miRNAs identified using high–throughput sequencing in this study against the human miRNA datasets in miRBase, we found that hsa-miR-9, hsa-miR-34 and hsa-miR-143 are significantly downregulated and hsa-miR-200 is significantly upregulated in ENA. [score:7]
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4
[+] score: 8
The mir-10 (MIPF0000033), mir-143 (MIPF0000094), let-7 (MIPF0000002) and mir-26 (MIPF0000043) families were found to be preferentially expressed in ovine ovary. [score:3]
In previous studies, miR-21 was identified to be able to promote follicular cell survival during ovulation [29], miR-143 was critical for the formation of mouse primordial follicles [30] and let-7b was shown to be necessary for normal development of the corpus luteum [10]. [score:2]
For instance, miR-143 was significantly enriched in the GnRH signaling and progesterone -mediated oocyte maturation pathways, which are crucial for ovarian activity by influencing endocrine function and follicular development. [score:2]
Some of the abundant miRNAs in the anestrous ovary of Tan sheep, including miR-143, miR-26a, let-7 and miR-21, were also reported to be highly abundant in ovaries of human, cow [23– 25], pig [26], adult and neonatal mouse [27, 28] and sheep [2, 3]. [score:1]
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5
[+] score: 8
In the three libraries, miR-143 showed the highest expression level, with 4,606,500, 7,297,109, and 6,614,344 reads in the DU, CE, and CO libraries. [score:3]
According to previous research, miR-143 primarily performs important functions as a tumor suppressor. [score:3]
In the DU, CE, and CO libraries, miR-143 had the largest number of reads, while the miR-21, miR-148a, miR-26, and let-7 families were the next most abundant. [score:1]
In the intestines, miR-143 primarily functions in colorectal cancer and post-cancer repair of intestinal epithelial injury [43] and is likely involved in nutrient digestion and absorption. [score:1]
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6
[+] score: 7
LMO4, the target gene of miR-143, regulates EMT that is caused by TGF-β. [score:4]
In addition, Trakooljul et al. found that most target genes of miR-143 were related to cell proliferation, apoptosis, and tumorigenesis [40]. [score:3]
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7
[+] score: 6
Other miRNAs from this paper: mmu-mir-1a-1, mmu-mir-127, mmu-mir-134, mmu-mir-136, mmu-mir-154, mmu-mir-181a-2, mmu-mir-143, mmu-mir-196a-1, mmu-mir-196a-2, mmu-mir-21a, rno-mir-329, mmu-mir-329, mmu-mir-1a-2, mmu-mir-181a-1, mmu-mir-181b-1, mmu-mir-181c, mmu-mir-375, mmu-mir-379, mmu-mir-181b-2, rno-mir-21, rno-mir-127, rno-mir-134, rno-mir-136, rno-mir-143, rno-mir-154, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-196a, rno-mir-181a-1, mmu-mir-196b, rno-mir-196b-1, mmu-mir-412, mmu-mir-370, oar-mir-431, oar-mir-127, oar-mir-432, oar-mir-136, mmu-mir-431, mmu-mir-433, rno-mir-431, rno-mir-433, ssc-mir-181b-2, ssc-mir-181c, ssc-mir-136, ssc-mir-196a-2, ssc-mir-21, rno-mir-370, rno-mir-412, rno-mir-1, mmu-mir-485, mmu-mir-541, rno-mir-541, rno-mir-493, rno-mir-379, rno-mir-485, mmu-mir-668, bta-mir-21, bta-mir-181a-2, bta-mir-127, bta-mir-181b-2, bta-mir-181c, mmu-mir-181d, mmu-mir-493, rno-mir-181d, rno-mir-196c, rno-mir-375, mmu-mir-1b, bta-mir-1-2, bta-mir-1-1, bta-mir-134, bta-mir-136, bta-mir-143, bta-mir-154a, bta-mir-181d, bta-mir-196a-2, bta-mir-196a-1, bta-mir-196b, bta-mir-329a, bta-mir-329b, bta-mir-370, bta-mir-375, bta-mir-379, bta-mir-412, bta-mir-431, bta-mir-432, bta-mir-433, bta-mir-485, bta-mir-493, bta-mir-541, bta-mir-181a-1, bta-mir-181b-1, ssc-mir-1, ssc-mir-181a-1, mmu-mir-432, rno-mir-668, ssc-mir-143, ssc-mir-181a-2, ssc-mir-181b-1, ssc-mir-181d, ssc-mir-196b-1, ssc-mir-127, ssc-mir-432, oar-mir-21, oar-mir-181a-1, oar-mir-493, oar-mir-433, oar-mir-370, oar-mir-379, oar-mir-329b, oar-mir-329a, oar-mir-134, oar-mir-668, oar-mir-485, oar-mir-154a, oar-mir-154b, oar-mir-541, oar-mir-412, mmu-mir-21b, mmu-mir-21c, ssc-mir-196a-1, ssc-mir-196b-2, ssc-mir-370, ssc-mir-493, bta-mir-154c, bta-mir-154b, oar-mir-181a-2, chi-mir-1, chi-mir-127, chi-mir-134, chi-mir-136, chi-mir-143, chi-mir-154a, chi-mir-154b, chi-mir-181b, chi-mir-181c, chi-mir-181d, chi-mir-196a, chi-mir-196b, chi-mir-21, chi-mir-329a, chi-mir-329b, chi-mir-379, chi-mir-412, chi-mir-432, chi-mir-433, chi-mir-485, chi-mir-493, rno-mir-196b-2, bta-mir-668, ssc-mir-375
For example, miR-273 and the lys-6 miRNA have been shown to be involved in the development of the nervous system in nematode worm [3]; miR-430 was reported to regulate the brain development of zebrafish [4]; miR-181 controlled the differentiation of mammalian blood cell to B cells [5]; miR-375 regulated mammalian islet cell growth and insulin secretion [6]; miR-143 played a role in adipocyte differentiation [7]; miR-196 was found to be involved in the formation of mammalian limbs [8]; and miR-1 was implicated in cardiac development [9]. [score:6]
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8
[+] score: 5
For example, circRNAs (circRNA 0000385, circRNA 0000582 and circRNA 0001099 etc) have multiple conservative target sites for muscle development-related miRNAs (miR-143, miR-133 and miR-23etc, respectively). [score:4]
There are many circRNAs that interact with a lot of muscle-related miRNAs (miR-143, miR-133 and miR-23 etc). [score:1]
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9
[+] score: 5
We further analyzed the microarray result and found that only 22 miRNAs; let-7a, let-7c, miR-1, miR-206, miR-133a, miR-133b, miR-128–1, miR-128–2, miR-140, miR-143, miR-199a, miR-22, miR-26a, miR-27b, miR-29a, miR-29c, miR-378–1, miR-378–2, miR-486, miR-499, miR-99a and miR-101–2 have high levels of expression. [score:3]
8 -174.8 0 A>G -174.8 -175.5 -0.7 miR-140 T>G -256.0 -256.7 -0.7 C>T -256.0 -256.9 -0.9 miR-143 G>C -238.2 -238.3 -0.1 miR-128–1 G>A -120.6 -119.8 0.8 ATCATGC -120.6 -121.1 -0.5 miR-128–2 T>C -235.3 -233.7 1.6 T>C -235.3 -234.2 1.1 T>C -235.3 -230.2 5.1 Let-7a T>C -159.4 -157.3 2.1 G>A -159. [score:1]
The genome context of miR-99a, miR-199a, miR-143 and let-7a were from the Ovis aries genome, and the remainder were from the Bos taurus genome because their information in the Ovis aries genome cannot be searched. [score:1]
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10
[+] score: 3
Previous studies have shown an increase in miR-143 during human and murine preadipocyte differentiation, and the following experiment verified that it inhibited preadipocyte differentiation [30– 32]. [score:3]
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11
[+] score: 3
The ten most highly ranked miRNAs are relatively well conserved across species – for example, four miRNAs (miR-143, let-7a, let-7f, miR-148a) in pig testis 47 and two miRNAs (let-7a, let-7f) in human testis 48 ranked within the ten most highly expressed miRNAs found in this study. [score:3]
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12
[+] score: 3
In the whole hair cycle, the abundance of expression of let-7a-5p, let-7f, let-7b, let-7c, let-7g, miR-199a-3p, miR-143, miR-1, and miR-320a reached their highest levels in the present study (Table  2). [score:3]
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