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2 publications mentioning fhe-let-7

Open access articles that are associated with the species Fasciola hepatica and mention the gene name let-7. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 13
For example, C. elegans lin-4 and let-7 family members are important for correct larval development, the mir-36 family is essential for embryonic development, the mir-51 family is required for pharynx attachment during embryogenesis and the mir-58 family is involved in regulating locomotion, growth and development of arrested dauer stage larvae (Alvarez-Saavedra and Horvitz, 2010). [score:5]
In C. elegans, lin-4 or let-7 loss of function leads to phenotypes opposite to that of target gene loss, demonstrating the inverse nature of this regulation. [score:4]
C. elegans lin-4 and let-7 were identified as non-coding RNAs essential for correct developmental progression from larval stages L2 to L3 and from L4 to adult worms, respectively (Lee et al., 1993; Reinhart et al., 2000). [score:2]
The identification of let-7 in higher organisms, in which the sequence is perfectly conserved, resulted in the recognition of the widespread importance of miRNA -mediated gene regulation. [score:2]
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[+] score: 2
The REL of miR-10 was 2.33 fold higher in F. gigantica (2.21±0.16) than that in F. hepatica (0.95±0.05); and the let-7 was 1.14 fold higher F. gigantica (1.14±0.30) than that in F. hepatica (1.00±0.16). [score:1]
Furthermore, the 8 conserved miRNAs were identified as originating from 6 miRNA families, namely miR-124, miR-2 (miR-2b, miR-2e), bantam, miR-10, let-7 and miR-71 (miR-71, miR-71b). [score:1]
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